公开(公告)号：US20120100146A1

公开(公告)日：2012-04-26

申请号：US13341457

申请日：2011-12-30

申请人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil D. Pandit

发明人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil D. Pandit

IPC分类号： A61K39/395 ,  A61P11/06 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

摘要翻译： 本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。 本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。 本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。 还涉及调节所公开的基因或基因产物的活性的配体。 此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

公开(公告)号：US08907067B2

公开(公告)日：2014-12-09

申请号：US13341457

申请日：2011-12-30

申请人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil D. Pandit

发明人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil D. Pandit

IPC分类号： C07K16/26

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

摘要翻译： 本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。 本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。 本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。 还涉及调节所公开的基因或基因产物的活性的配体。 此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

公开(公告)号：US08105826B2

公开(公告)日：2012-01-31

申请号：US11690650

申请日：2007-03-23

申请人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil D. Pandit

发明人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil D. Pandit

IPC分类号： C12N5/10

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

摘要翻译： 本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。 本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。 本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。 还涉及调节所公开的基因或基因产物的活性的配体。 此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

公开(公告)号：US07205146B1

公开(公告)日：2007-04-17

申请号：US10021698

申请日：2001-10-22

申请人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： Tim Keith ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： C12N5/10 ,  C12N15/70 ,  C12N1/20 ,  C12N1/00 ,  C07H21/04

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

摘要翻译： 本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。 本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。 本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。 还涉及调节所公开的基因或基因产物的活性的配体。 此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

公开(公告)号：US20090292002A1

公开(公告)日：2009-11-26

申请号：US11690650

申请日：2007-03-23

申请人： TIM KEITH ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josee Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： TIM KEITH ,  Randall D. Little ,  Paul Van Eerdewegh ,  Josee Dupuis ,  Richard G. Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： A61K31/70 ,  A61P43/00 ,  C07H21/00 ,  C07H21/04 ,  C12N1/00 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12Q1/68 ,  A61K48/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

摘要翻译： 本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。 本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。 本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。 还涉及调节所公开的基因或基因产物的活性的配体。 此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

公开(公告)号：US07407804B1

公开(公告)日：2008-08-05

申请号：US10743704

申请日：2003-12-22

申请人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： C07H21/02 ,  C12N1/20 ,  C12N15/00 ,  C12N5/02

CPC分类号： C07K16/18 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

摘要翻译： 本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

公开(公告)号：US07501118B2

公开(公告)日：2009-03-10

申请号：US10670184

申请日：2003-09-24

申请人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： A61K39/395 ,  A61K39/44 ,  C07K16/18 ,  C07K17/00

CPC分类号： C12N9/6489 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156

摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

摘要翻译： 本发明涉及包含人染色体20p13-p12的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

公开(公告)号：US06683165B1

公开(公告)日：2004-01-27

申请号：US09548797

申请日：2000-04-13

申请人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josée Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： C07H1900

CPC分类号： C12N9/6489 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156

摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

摘要翻译： 本发明涉及包含人染色体20p13-p12的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

公开(公告)号：US20110201782A1

公开(公告)日：2011-08-18

申请号：US13087480

申请日：2011-04-15

申请人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josèe Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josèe Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： C07K14/435

CPC分类号： C07K16/18 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

摘要翻译： 本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

公开(公告)号：US08124734B2

公开(公告)日：2012-02-28

申请号：US13087480

申请日：2011-04-15

申请人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josèe Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

发明人： Tim Keith ,  Randall Little ,  Paul Van Eerdewegh ,  Josèe Dupuis ,  Richard Del Mastro ,  Jason Simon ,  Kristina Allen ,  Sunil Pandit

IPC分类号： C07K1/00

CPC分类号： C07K16/18 ,  C07K14/47 ,  C07K2317/24

摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

摘要翻译： 本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。