公开(公告)号：US08666137B2

公开(公告)日：2014-03-04

申请号：US13390525

申请日：2010-09-01

申请人： Tim Nielsen ,  Thomas Koehler ,  Bernhard Brendel

发明人： Tim Nielsen ,  Thomas Koehler ,  Bernhard Brendel

IPC分类号： G06T5/00

CPC分类号： G06T11/005 ,  A61B6/5258 ,  G06T2211/412

摘要： The invention relates to a projection values processing apparatus (1) for processing acquired projection values. A first image is reconstructed from acquired projection values under consideration of a reconstruction assumption by a reconstruction unit (13). A simulated projection values determining unit (14) determines simulated projection values by simulating a projection through the reconstructed first image under consideration of the reconstruction assumption, and inconsistency values are determined for the acquired projection values by an inconsistency determining unit (15), wherein an inconsistency value is indicative of a degree of inconsistency of a respective acquired projection value with the reconstruction assumption, by comparing the acquired projection values and the simulated projection values. The inconsistency values can be used for different purposes, for example, improving the quality of a reconstructed image or indicating image elements being affected by an inconsistency between reconstruction assumption and acquired projection values.

摘要翻译： 本发明涉及一种用于处理所获取的投影值的投影值处理装置（1）。 在由重建单元（13）考虑重建假设的情况下，从获取的投影值重建第一图像。 模拟投影值确定单元（14）通过在考虑重构假设的情况下模拟通过重构的第一图像的投影来确定模拟投影值，并且通过不一致性确定单元（15）为所获取的投影值确定不一致值，其中， 通过比较所获取的投影值和模拟投影值，不一致值表示相应的获得的投影值与重建假设的不一致程度。 不一致值可以用于不同的目的，例如，改善重建图像的质量或指示图像元素受到重建假设和所获取的投影值之间的不一致的影响。

公开(公告)号：US20080242960A1

公开(公告)日：2008-10-02

申请号：US12066561

申请日：2006-09-07

申请人： Tim Nielsen ,  Thomas Koehler

发明人： Tim Nielsen ,  Thomas Koehler

IPC分类号： A61B5/1455 ,  A61B5/0402 ,  A61B5/055

CPC分类号： A61B5/0073 ,  A61B5/14551 ,  A61B5/1495

摘要： In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

摘要翻译： 在光学层析成像中，图像重构可能需要校准数据。 根据本发明的示例性实施例，感兴趣的对象被用于校准，其中在感兴趣对象的高度充氧阶段期间获取图像数据，并且其中在对象的低氧合期期间获取校准数据 出于兴趣。 这可以提供改进的校准，导致改善的图像质量。

公开(公告)号：US08406840B2

公开(公告)日：2013-03-26

申请号：US12066561

申请日：2006-09-07

申请人： Tim Nielsen ,  Thomas Koehler

发明人： Tim Nielsen ,  Thomas Koehler

IPC分类号： A61B5/00

CPC分类号： A61B5/0073 ,  A61B5/14551 ,  A61B5/1495

摘要： In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

摘要翻译： 在光学层析成像中，图像重构可能需要校准数据。 根据本发明的示例性实施例，感兴趣的对象被用于校准，其中在感兴趣对象的高度充氧阶段期间获取图像数据，并且其中在对象的低氧合期期间获取校准数据 出于兴趣。 这可以提供改进的校准，导致改善的图像质量。

公开(公告)号：US20100238441A1

公开(公告)日：2010-09-23

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/49 ,  G01N21/00

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US07672424B2

公开(公告)日：2010-03-02

申请号：US11575902

申请日：2005-09-22

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Roland Proksa ,  Dominic J. Heuscher

IPC分类号： A61B6/00

CPC分类号： G06T11/006

摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.

摘要翻译： 放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。 基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹 （12）。 基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

公开(公告)号：US20100030084A1

公开(公告)日：2010-02-04

申请号：US12514589

申请日：2007-11-12

申请人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

发明人： Andy Ziegler ,  Thomas Koehler ,  Tim Nielsen ,  Martinus Bernardus Van Der Mark ,  Michael Cornelis Van Beek ,  Levinus Pieter Bakker

IPC分类号： A61B6/00 ,  G06K9/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  G01N21/4795 ,  G01N21/6456

摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

申请人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

发明人： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC分类号： G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

摘要翻译： 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US20090326382A1

公开(公告)日：2009-12-31

申请号：US12307777

申请日：2007-06-25

申请人： Tim Nielsen ,  Thomas Koehler

发明人： Tim Nielsen ,  Thomas Koehler

IPC分类号： A61B6/00

CPC分类号： A61B5/4312 ,  A61B5/0091

摘要： A device for determining a concentration-related quantity of a fluorescent contrast agent applied to an object (2), in particular a turbid medium. Said device generally comprises a source (4) of electromagnetic radiation for irradiating the object (2) at an excitation wavelength and at least one first detecting means (6, 7.1, 7.2, . . . , 8) for detecting fluorescent electromagnetic radiation emitted by the contrast agent at a fluorescence wavelength, said first detecting means producing fluorescence intensity data (F). The proposed device further comprises at least one second detecting means (6, 7.1, 7.2, . . . ) for detecting electromagnetic radiation transmitted by the object (2) at the excitation wavelength, said second detecting means producing transmission intensity data (T), and evaluating means (10) adapted to receive the transmission intensity data and the fluorescence intensity data and to determine said concentration-related quantity of the contrast agent from a ratio (R) of fluorescence intensity data and transmission intensity data.

摘要翻译： 一种用于确定应用于物体（2）的荧光对比剂的浓度相关量的装置，特别是混浊介质。 所述装置通常包括用于以激发波长照射物体（2）的电磁辐射源（4）和至少一个第一检测装置（6,7.1,7.2，...，8），用于检测由 所述造影剂处于荧光波长，所述第一检测装置产生荧光强度数据（F）。 所提出的装置还包括用于检测由激光波长发射的物体（2）的电磁辐射的至少一个第二检测装置（6,7.1,7.2 ...），所述第二检测装置产生发射强度数据（T） 以及评估装置（10），其适于从荧光强度数据和透射强度数据的比率（R）接收透射强度数据和荧光强度数据并确定造影剂的浓度相关量。

公开(公告)号：US20090153850A1

公开(公告)日：2009-06-18

申请号：US12304276

申请日：2007-06-13

申请人： Tim Nielsen ,  Thomas Koehler

发明人： Tim Nielsen ,  Thomas Koehler

IPC分类号： G01J1/10 ,  G01J1/58

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  A61B2560/0233 ,  G01N21/278 ,  G01N21/4795 ,  G01N21/64

摘要： The invention relates to a device for imaging an interior of a turbid medium and a medical image acquisition device comprising: a) a measurement volume (15) for accommodating the turbid medium (45); b) a light source (5) for irradiating the turbid medium (45); c) a photodetector unit 10 for detecting light emanating from the measurement volume (15). The device for imaging an interior of the turbid medium and the medical image acquisition device are adapted such that the devices further comprise a calibration device (55, 60) arranged to be optically coupled to the measurement volume (15) and comprising a calibration light source (65) arranged to simultaneously generate the excitation light and further light corresponding to the fluorescence light. The invention also relates to a calibration device (60) arranged to be inserted into a receptacle (20) that comprises a measurement volume (15) for receiving a turbid medium (45) in a device for imaging an interior of a turbid medium (45), having a contact part (70) comprising a contact surface (75) that fits at least a part of the surface of the receptacle (20) facing the measurement volume (15), and having a calibration light source (65) arranged to simultaneously generate light that causes fluorescent emission in a fluorescent agent present in the turbid medium and further light corresponding to the fluorescence light. The contact part (70) may be removable.

摘要翻译： 本发明涉及一种用于对浑浊介质内部进行成像的装置和医用图像采集装置，包括：a）用于容纳混浊介质的测量体积（15）; b）用于照射混浊介质（45）的光源（5）; c）用于检测从测量体积（15）发出的光的光电检测器单元10。 用于对浑浊介质和医学图像采集装置的内部进行成像的装置适于使得装置还包括校准装置（55,60），该校准装置被布置成光学耦合到测量体积（15），并且包括校准光源 （65），其被布置成同时产生对应于所述荧光的激发光和另外的光。 本发明还涉及一种被布置成插入到容器（20）中的校准装置（60），该容器包括用于在混浊介质（45）的内部成像的装置中接收混浊介质（45）的测量体积 ），其具有接触部分（70），所述接触部分（70）包括接合表面（75），所述接触表面（75）适合面向所述测量体积（15）的所述容器（20）的表面的至少一部分，并且具有校准光源（65） 同时产生在混浊介质中存在的荧光剂中引起荧光发射的光，并且产生对应于荧光的另外的光。 接触部分（70）可以是可移除的。

公开(公告)号：US20120148136A1

公开(公告)日：2012-06-14

申请号：US13390525

申请日：2010-09-01

申请人： Tim Nielsen ,  Thomas Koehler ,  Bernhard Brendel

发明人： Tim Nielsen ,  Thomas Koehler ,  Bernhard Brendel

IPC分类号： G06K9/00

CPC分类号： G06T11/005 ,  A61B6/5258 ,  G06T2211/412

摘要： The invention relates to a projection values processing apparatus (1) for processing acquired projection values. A first image is reconstructed from acquired projection values under consideration of a reconstruction assumption by a reconstruction unit (13). A simulated projection values determining unit (14) determines simulated projection values by simulating a projection through the reconstructed first image under consideration of the reconstruction assumption, and inconsistency values are determined for the acquired projection values by an inconsistency determining unit (15), wherein an inconsistency value is indicative of a degree of inconsistency of a respective acquired projection value with the reconstruction assumption, by comparing the acquired projection values and the simulated projection values. The inconsistency values can be used for different purposes, for example, improving the quality of a reconstructed image or indicating image elements being affected by an inconsistency between reconstruction assumption and acquired projection values.

摘要翻译： 本发明涉及一种用于处理所获取的投影值的投影值处理装置（1）。 在由重建单元（13）考虑重建假设的情况下，从获取的投影值重建第一图像。 模拟投影值确定单元（14）通过在考虑重构假设的情况下模拟通过重构的第一图像的投影来确定模拟投影值，并且通过不一致性确定单元（15）为所获取的投影值确定不一致值，其中， 通过比较所获取的投影值和模拟投影值，不一致值表示相应的获得的投影值与重建假设的不一致程度。 不一致值可以用于不同的目的，例如，改善重建图像的质量或指示图像元素受到重建假设和所获取的投影值之间的不一致的影响。