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    Purified and isolated platelet calcium channel nucleic acids
    2.
    发明授权
    Purified and isolated platelet calcium channel nucleic acids 失效
    纯化和分离的血小板钙通道核酸

    公开(公告)号：US07041475B2

    公开(公告)日：2006-05-09

    申请号：US10029413

    申请日：2001-12-20

    申请人： Nadia Malouf ,  Timothy C. Nichols

    发明人： Nadia Malouf ,  Timothy C. Nichols

    IPC分类号： C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/00 ,  C07H21/04

    CPC分类号： G01N33/6872 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705

    摘要： Isolated and purified platelet voltage dependent calcium channel (VDCC) α1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to platelet VDCC α1 subunit polypeptides, and methods of producing the same, are also disclosed. Platelet VDCC α1 subunit polypeptides have biological activity in calcium transport. Thus, therapeutic and diagnostic methods involving this activity are also disclosed.

    摘要翻译： 分离和纯化的血小板电压依赖性钙通道（VDCC）α1亚基多肽和编码其的核酸分子。 还公开了重组宿主细胞，重组核酸和重组蛋白，以及各自产生的方法。 还公开了血小板VDCCα1亚基多肽的分离和纯化的抗体及其制备方法。 血小板VDCCα1亚基多肽在钙转运中具有生物活性。 因此，还公开了涉及该活性的治疗和诊断方法。