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公开(公告)号:US20060178371A1
公开(公告)日:2006-08-10
申请号:US11395676
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Carmen Alvarez , Tin-Yau Chan , Chad Knutson , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Carmen Alvarez , Tin-Yau Chan , Chad Knutson , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park
IPC分类号: A61K31/519 , A61K31/7048 , A61K31/704 , A61K31/525 , A61K31/66 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号:US20070054925A1
公开(公告)日:2007-03-08
申请号:US11396079
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04 , A61K31/495
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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3.
公开(公告)号:US20070054906A1
公开(公告)日:2007-03-08
申请号:US11396001
申请日:2006-03-31
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/5377 , A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20070037824A1
公开(公告)日:2007-02-15
申请号:US10654546
申请日:2003-09-03
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhen He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs
IPC分类号: A61K31/519 , C07D487/02
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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5.
公开(公告)号:US20080050384A1
公开(公告)日:2008-02-28
申请号:US11788847
申请日:2007-04-20
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhenmin He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs , Paul Kirschmeier , Rajat Bannerji
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Ronald Doll , Viyyoor Girijavallabhan , Alan Mallams , Carmen Alvarez , Kartik Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry Fischmann , Lawrence Dillard , Vinh Tran , Zhenmin He , Ray James , Haengsoon Park , Vidyadhar Paradkar , Douglas Hobbs , Paul Kirschmeier , Rajat Bannerji
IPC分类号: A61K31/519 , A61K31/33 , A61K31/4965 , A61K31/56 , A61K31/675 , A61K33/24 , A61K38/46 , A61P19/02 , A61P35/00 , A61P43/00 , A61P29/00 , A61K39/395 , A61K33/36 , A61K31/7004 , A61K31/655 , A61K31/535 , A61K31/497
CPC分类号: A61K31/33 , A61K31/4965 , A61K31/497 , A61K31/519 , A61K31/535 , A61K31/555 , A61K31/56 , A61K31/655 , A61K31/675 , A61K31/7004 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20080004257A1
公开(公告)日:2008-01-03
申请号:US11338501
申请日:2006-01-24
申请人: Tin-Yau Chan , Thierry Fischmann , Mark McCoy , Brian McKittrick , Andrew Prongay , Haiyan Pu , Li Wang , Li Xiao
发明人: Tin-Yau Chan , Thierry Fischmann , Mark McCoy , Brian McKittrick , Andrew Prongay , Haiyan Pu , Li Wang , Li Xiao
IPC分类号: A61K31/53 , A61K31/551 , A61P25/00 , A61P3/00 , A61P35/00 , A61P37/00 , A61P5/00 , A61P9/00 , C07D403/14
CPC分类号: C07D403/04
摘要: A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as immunodeficiencies, cancers, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease.
摘要翻译: 具有式(I)的通式结构的化合物或其药学上可接受的盐,溶剂化物或酯可用于治疗疾病,病症或病症,例如免疫缺陷,癌症,心血管疾病,内分泌紊乱,帕金森病,代谢 疾病,肿瘤发生,阿尔茨海默病,心脏病,糖尿病,神经变性,炎症,肾脏疾病,动脉粥样硬化和气道疾病。
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公开(公告)号:US20080081360A1
公开(公告)日:2008-04-03
申请号:US11873831
申请日:2007-10-17
申请人: Jessie English , Thierry Fischmann , Thomas Hesson , Alan Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Taremi
发明人: Jessie English , Thierry Fischmann , Thomas Hesson , Alan Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Taremi
CPC分类号: C12N9/1205 , C07K2299/00
摘要: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
摘要翻译: 本发明涉及ERK2多肽的结晶及其复合物,其特别用于结构辅助药物设计。
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公开(公告)号:US20060088924A1
公开(公告)日:2006-04-27
申请号:US11233581
申请日:2005-09-23
申请人: Jessie English , Thierry Fischmann , Thomas Hesson , Alan Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Taremi
发明人: Jessie English , Thierry Fischmann , Thomas Hesson , Alan Hruza , Weihong Jin , Paul Reichert , Catherine Smith , Shahriar Taremi
CPC分类号: C12N9/1205 , C07K2299/00
摘要: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.
摘要翻译: 本发明涉及ERK2多肽的结晶及其复合物,其特别用于结构辅助药物设计。
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