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公开(公告)号：US07795211B2
公开(公告)日：2010-09-14
申请号：US10652993
申请日：2003-08-29
IPC分类号： G01N33/574 , C12Q1/68 , A61K39/00 , C07K14/435 , C12Q1/37
CPC分类号： C07K14/435 , A61K39/00 , A61K2039/5154 , C12N9/6424 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/573 , G01N33/57449 , G01N33/57492 , G01N2333/96433 , G01N2500/20
摘要： The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
摘要翻译： 本发明公开了蛋白酶hepsin在卵巢和其他恶性肿瘤中特异性过度表达。 许多hepsin肽可诱导对hepsin的免疫应答，从而证明这些肽在监测和发展卵巢癌和其他恶性肿瘤的免疫治疗方面的潜力。 还提供了可用作卵巢癌细胞，前列腺癌细胞或肾癌细胞的标志物的hepsin蛋白质变体。
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公开(公告)号：US20110086056A1
公开(公告)日：2011-04-14
申请号：US12807390
申请日：2010-09-03
CPC分类号： C07K14/435 , A61K39/00 , A61K2039/5154 , C12N9/6424 , C12Q1/37 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/573 , G01N33/57449 , G01N33/57492 , G01N2333/96433 , G01N2500/20
摘要： The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
摘要翻译： 本发明公开了蛋白酶hepsin在卵巢和其他恶性肿瘤中特异性过度表达。 许多hepsin肽可诱导对hepsin的免疫应答，从而证明这些肽在监测和发展卵巢癌和其他恶性肿瘤的免疫治疗方面的潜力。 还提供了可用作卵巢癌细胞，前列腺癌细胞或肾癌细胞的标志物的hepsin蛋白质变体。
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公开(公告)号：US06875609B2
公开(公告)日：2005-04-05
申请号：US10102283
申请日：2002-03-20
IPC分类号： A61K39/00 , C07K14/435 , C12Q1/37 , C12Q1/68 , G01N33/573 , G01N33/574 , A01N61/00 , A01N37/18 , A61K31/00 , A61K38/00 , A61K38/16
CPC分类号： C07K14/435 , A61K39/00 , A61K2039/5154 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/158 , G01N33/573 , G01N33/57449 , G01N33/57492 , G01N2333/96433 , G01N2500/20
摘要： The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The detected proteases are themselves specifically over-expressed in certain cancers, and the presence of their genetic precursors may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
摘要翻译： 所公开的与组织cDNA的定量扩增（PCR）组合使用的核酸引物组可以指示组织样品中特异性蛋白酶的存在。 具体而言，本发明涉及hepsin蛋白酶的表达。 检测到的蛋白酶本身在某些癌症中特异性过度表达，并且其遗传前体的存在可用于早期检测相关的卵巢癌和其他恶性肿瘤，以及用于设计用于癌症治疗的互动疗法。
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公开(公告)号：US20090010842A1
公开(公告)日：2009-01-08
申请号：US11973468
申请日：2007-10-09
IPC分类号： A61K39/44 , C12Q1/37 , C12N5/06 , C12N15/11 , C12N15/85 , A61P35/00 , A61K31/7088 , A61K38/48 , A61K51/10
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/3069 , C12N9/6424 , C12N9/6472 , C12N2799/022 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译： 本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质酶糜蛋白酶（SCCE）。 许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。
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公开(公告)号：US06627403B2
公开(公告)日：2003-09-30
申请号：US09918243
申请日：2001-07-30
IPC分类号： C12Q168
CPC分类号： C12N9/6424 , A61K38/00 , A61K39/00 , A61K48/00 , C12N9/6472 , C12Q1/37 , C12Q1/6886 , C12Q2600/136 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N2333/976
摘要： The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected proteases are themselves specifically overexpressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment. More specifically, the present invention relates to the uses of stratum corneum chymotrytic enzyme as a marker for ovarian tumor cells.
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6.发明授权公开(公告)号：US07335351B2
公开(公告)日：2008-02-26
申请号：US10831075
申请日：2004-04-23
CPC分类号： C12N9/6424 , A61K38/482 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/40 , C12N9/6472 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译： 本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质层糜蛋白酶（SCCE）。 许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。
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公开(公告)号：US20110213337A1
公开(公告)日：2011-09-01
申请号：US13066897
申请日：2011-04-27
IPC分类号： A61M5/00 , C12N5/078 , C12N15/85 , C12Q1/37 , A61K39/00 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C07H21/04 , A61K31/7088 , A61P37/04 , A61P35/00
CPC分类号： C12N5/064 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , C12N9/6424 , C12N15/1137 , C12N2310/11 , C12Q1/37 , C12Q1/6851 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , C12Y304/21106 , G01N33/57449 , G01N2500/02
摘要： The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The detected proteases are themselves specifically over-expressed in certain cancers, and the presence of their genetic precursors may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
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8.发明申请公开(公告)号：US20080279872A1
公开(公告)日：2008-11-13
申请号：US12005175
申请日：2007-12-26
CPC分类号： C12N9/6424 , A61K38/482 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/40 , C12N9/6472 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译： 本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质层糜蛋白酶（SCCE）。 许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。
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9.发明授权公开(公告)号：US07282198B2
公开(公告)日：2007-10-16
申请号：US10372521
申请日：2003-02-21
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/3069 , C12N9/6424 , C12N9/6472 , C12N2799/022 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译： 本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质层糜蛋白酶（SCCE）。 许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。
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10.发明授权公开(公告)号：US08187587B2
公开(公告)日：2012-05-29
申请号：US12005175
申请日：2007-12-26
CPC分类号： C12N9/6424 , A61K38/482 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/40 , C12N9/6472 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译： 本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质层糜蛋白酶（SCCE）。 许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。
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