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公开(公告)号:US20060173183A1
公开(公告)日:2006-08-03
申请号:US11324037
申请日:2005-12-30
申请人: Timothy Powers , Christoph Steeneck , Ralf Biesinger , Harald Bluhm , Hongbo Deng , Rory Dodd , Brian Gallagher , Christian Gege , Matthias Hochgurtel , Andrew Kiely , Frank Richter , Matthias Schneider , Irving Sucholeiki , Joshua Van Veldhuizen , Xinyuan Wu , Arthur Taveras
发明人: Timothy Powers , Christoph Steeneck , Ralf Biesinger , Harald Bluhm , Hongbo Deng , Rory Dodd , Brian Gallagher , Christian Gege , Matthias Hochgurtel , Andrew Kiely , Frank Richter , Matthias Schneider , Irving Sucholeiki , Joshua Van Veldhuizen , Xinyuan Wu , Arthur Taveras
IPC分类号: C07D417/02 , C07D403/02 , C07D413/02
CPC分类号: C07D239/28 , C07D239/30 , C07D239/42 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
摘要翻译: 本发明一般涉及含有双酰胺基团的药物,特别涉及多元双酰胺MMP-13抑制剂化合物。 更具体地,本发明提供了一类新的MMP-13抑制化合物,其包含与杂环部分组合的嘧啶基双酰胺基团,其相对于目前已知的含有MMP-1的双酰胺基团显示增加的效力和溶解度, 13抑制剂。
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公开(公告)号:US20080161300A1
公开(公告)日:2008-07-03
申请号:US12001041
申请日:2007-12-07
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/536 , A61K31/519 , C07D265/36 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US07795245B2
公开(公告)日:2010-09-14
申请号:US12001043
申请日:2007-12-07
申请人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人: Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号: A61K31/397 , A61K31/519 , A61K31/535 , A01N43/90 , C07D487/00 , C07D413/00
CPC分类号: C07D487/04
摘要: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺基的药剂,特别涉及具有下式的含酰胺的杂双环金属蛋白酶抑制剂化合物:其中R1,R2,R3和R4如说明书中所定义。 更具体地,本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物,其含有杂双环化合物的酰胺,其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号:US20080261968A1
公开(公告)日:2008-10-23
申请号:US11986626
申请日:2007-11-20
申请人: Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
发明人: Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
IPC分类号: A61K31/5375 , C07D239/72 , A61K31/517 , A61K31/52 , C07D413/02 , A61P19/02 , A61K31/519 , C07D473/00 , C07D495/04
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含有氮杂双环的药物,特别涉及氮杂双环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新的氮杂双环MMP-3,MMP-8和/或MMP-13抑制化合物,其相对于目前已知的MMP-13,MMP-8和MMP- 3抑制剂。
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公开(公告)号:US20080207607A1
公开(公告)日:2008-08-28
申请号:US11986603
申请日:2007-11-20
申请人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgurtel , Hongbo Deng , Brian M. Gallagher , Irving Sucholeiki , Arthur Taveras
发明人: Christian Gege , Carine Chevrier , Matthias Schneider , Harald Bluhm , Matthias Hochgurtel , Hongbo Deng , Brian M. Gallagher , Irving Sucholeiki , Arthur Taveras
IPC分类号: A61K31/538 , C07D265/36 , C07D217/00 , A61K31/4725 , A61K31/541 , A61P29/00 , A61K31/519 , C07D239/00 , C07D417/14
CPC分类号: C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要: The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含有三氮杂环的药物,尤其涉及氮杂三环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新型的azatricyclic MMP-3,MMP-8和/或MMP-13抑制化合物,其与当前已知的MMP-13,MMP-8和MMP- 3抑制剂。
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公开(公告)号:US20080221093A1
公开(公告)日:2008-09-11
申请号:US12074917
申请日:2008-03-07
申请人: Christian Gege , Harald Bluhm , Matthias Hochgurtel , Matthias Schneider , Carine Chevrier , Arthur Taveras
发明人: Christian Gege , Harald Bluhm , Matthias Hochgurtel , Matthias Schneider , Carine Chevrier , Arthur Taveras
IPC分类号: A61K31/538 , C07D413/12 , A61P29/00 , A61P19/02
CPC分类号: C07D498/02 , C07D487/02 , C07D519/00
摘要: The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.
摘要翻译: 本发明一般涉及含有杂环部分的药剂,尤其涉及杂环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新的具有苯并恶嗪酮部分的杂环基MMP-13抑制化合物,其相对于目前已知的MMP-13抑制剂表现出增加的效力和选择性。
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公开(公告)号:US20080221092A1
公开(公告)日:2008-09-11
申请号:US11986586
申请日:2007-11-20
申请人: Harald Bluhm , Matthias Hochgurtel , Heiko Kroth , Michael Essers , Christian Gege , Frank Richter , Arthur Taveras
发明人: Harald Bluhm , Matthias Hochgurtel , Heiko Kroth , Michael Essers , Christian Gege , Frank Richter , Arthur Taveras
IPC分类号: A61K31/538 , C07D487/04 , A61P19/02 , A61P9/10 , A61K31/519
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention relates generally to amide containing heterobicyclic containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺的含杂双环的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类与当前已知的MMP-13和MMP-3抑制剂相比显示增加的效力和选择性的杂双环MMP-3和/或MMP-13抑制化合物。
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公开(公告)号:US20080221094A1
公开(公告)日:2008-09-11
申请号:US12074918
申请日:2008-03-07
IPC分类号: A61K31/538 , C07D401/12 , A61K31/517 , A61K31/4725 , A61P19/02 , C07D495/04 , C07D413/12
CPC分类号: C07D498/02 , C07D487/02 , C07D519/00
摘要: The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a squaramide moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.
摘要翻译: 本发明一般涉及含有杂环部分的药剂,尤其涉及杂环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一种具有方标酰胺部分的新一类杂环基MMP-13抑制化合物,其相对于目前已知的MMP-13抑制剂表现出增加的效力和选择性。
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公开(公告)号:US20080221083A1
公开(公告)日:2008-09-11
申请号:US11986625
申请日:2007-11-20
申请人: Matthias Hochgurtel , Harald Bluhm , Heiko Kroth , Michael Essers , Christian Gege , Arthur Taveras
发明人: Matthias Hochgurtel , Harald Bluhm , Heiko Kroth , Michael Essers , Christian Gege , Arthur Taveras
IPC分类号: A61K31/55 , C07D239/70 , A61K31/519 , C07D265/36 , A61P19/02 , A61P9/10 , A61P29/00 , C07D223/02 , A61K31/538 , C07D223/16
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention relates generally to amide containing heterobicyclic containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译: 本发明一般涉及含酰胺的含杂双环的药剂,特别涉及含酰胺的杂双环金属蛋白酶抑制化合物。 更具体地说,本发明提供了一类新型的杂双环MMP-3和/或MMP-13抑制化合物,与目前已知的MMP-13和MMP-3抑制剂相比,其表现出增加的效力和选择性。
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