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公开(公告)号：US20060173183A1
公开(公告)日：2006-08-03
申请号：US11324037
申请日：2005-12-30
申请人： Timothy Powers , Christoph Steeneck , Ralf Biesinger , Harald Bluhm , Hongbo Deng , Rory Dodd , Brian Gallagher , Christian Gege , Matthias Hochgurtel , Andrew Kiely , Frank Richter , Matthias Schneider , Irving Sucholeiki , Joshua Van Veldhuizen , Xinyuan Wu , Arthur Taveras
发明人： Timothy Powers , Christoph Steeneck , Ralf Biesinger , Harald Bluhm , Hongbo Deng , Rory Dodd , Brian Gallagher , Christian Gege , Matthias Hochgurtel , Andrew Kiely , Frank Richter , Matthias Schneider , Irving Sucholeiki , Joshua Van Veldhuizen , Xinyuan Wu , Arthur Taveras
IPC分类号： C07D417/02 , C07D403/02 , C07D413/02
CPC分类号： C07D239/28 , C07D239/30 , C07D239/42 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
摘要翻译： 本发明一般涉及含有双酰胺基团的药物，特别涉及多元双酰胺MMP-13抑制剂化合物。 更具体地，本发明提供了一类新的MMP-13抑制化合物，其包含与杂环部分组合的嘧啶基双酰胺基团，其相对于目前已知的含有MMP-1的双酰胺基团显示增加的效力和溶解度， 13抑制剂。
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公开(公告)号：US20080161300A1
公开(公告)日：2008-07-03
申请号：US12001041
申请日：2007-12-07
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Beisinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号： A61K31/536 , A61K31/519 , C07D265/36 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译： 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号：US20070155738A1
公开(公告)日：2007-07-05
申请号：US11602140
申请日：2006-11-20
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochguertel , Michael Essers , Joshua Van Veldhuizen , Bert Nolte , Brian Gallagher , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur Taveras
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/519 , C07D491/04 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译： 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号：US07795245B2
公开(公告)日：2010-09-14
申请号：US12001043
申请日：2007-12-07
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgurtel , Michael Essors , Joshua Van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号： A61K31/397 , A61K31/519 , A61K31/535 , A01N43/90 , C07D487/00 , C07D413/00
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译： 本发明一般涉及含酰胺基的药剂，特别涉及具有下式的含酰胺的杂双环金属蛋白酶抑制剂化合物：其中R1，R2，R3和R4如说明书中所定义。 更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其含有杂双环化合物的酰胺，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号：US20060293345A1
公开(公告)日：2006-12-28
申请号：US11440087
申请日：2006-05-22
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Matthias Hochguertel , Tim Feuerstein , Harald Bluhm , Irving Sucholeiki , Jurgen Boer , Xinyuan Wu , Matthias Schneider , Bert Nolte , Brian Gallagher , Joshua Van Veldhuizen , Hongbo Dong , Michael Essers , Heiko Kroth , Andrew Kiely , Timothy Powers , Arthur Taveras
IPC分类号： A61K31/519 , C07D491/04 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 inhibitors.
摘要翻译： 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地说，本发明提供了一类新型的杂双环MMP-13抑制化合物，其表现出与目前已知的MMP-13抑制剂有关的效力。
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公开(公告)号：US20120015920A1
公开(公告)日：2012-01-19
申请号：US13163457
申请日：2011-06-17
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, JR. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, JR. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号： A61K31/56 , A61K31/519 , A61K31/538 , A61P29/00 , A61P19/02 , A61P35/00 , A61P9/10 , A61P11/00 , A61P25/00 , A61P27/02 , A61P31/04 , A61P7/02 , A61P25/16 , A61P25/28 , A61P31/18 , C12N9/99 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译： 本发明一般涉及含酰胺基的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制剂化合物。 更具体地，本发明提供了一类新型的杂双环MMP-13抑制和MMP-3抑制化合物，其与当前已知的MMP-13和MMP-3抑制剂相比具有增强的效力。
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公开(公告)号：US08835441B2
公开(公告)日：2014-09-16
申请号：US13163457
申请日：2011-06-17
申请人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
发明人： Christoph Steeneck , Christian Gege , Frank Richter , Heiko Kroth , Matthias Hochgürtel , Michael Essers , Joshua van Veldhuizen , Bert Nolte , Brian M. Gallagher, Jr. , Tim Feuerstein , Matthias Schneider , Torsten Arndt , Hongbo Deng , Ralf Biesinger , Xinyuan Wu , Harald Bluhm , Irving Sucholeiki , Arthur G. Taveras
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates generally to amide containing heterobicyclic compounds having the following formulas: wherein R1, R2, D, and Q are as defined in the specification. More particularly, the present invention provides a new class of amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译： 本发明一般涉及具有下式的含酰胺的杂双环化合物：其中R1，R2，D和Q如说明书中所定义。 更具体地说，本发明提供了一类新的含有杂双环化合物的酰胺，其表现出与目前已知的MMP-13和MMP-3抑制剂有关的效力。
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公开(公告)号：US20080021024A1
公开(公告)日：2008-01-24
申请号：US11824525
申请日：2007-06-29
申请人： Irving Sucholeiki , Christian Gege , Brian Gallagher , Timothy Powers , Hongbo Deng , Xinyuan Wu , Christoph Steeneck , Andrew Kiely , Arthur Taveras
发明人： Irving Sucholeiki , Christian Gege , Brian Gallagher , Timothy Powers , Hongbo Deng , Xinyuan Wu , Christoph Steeneck , Andrew Kiely , Arthur Taveras
IPC分类号： C07D239/24 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/536 , A61P17/00 , C12N9/99 , C07D265/36 , A61P19/00 , A61P25/00 , A61P3/00 , A61P9/00
CPC分类号： C07D403/12 , C07D239/38 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： The present invention relates to amide containing aromatic MMP inhibiting compounds with a mono-amide heteroaromatic group, of formulas I and II:
摘要翻译： 本发明涉及具有式I和II的单酰胺杂芳族基团的含酰胺芳香族MMP抑制化合物：
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公开(公告)号：US20080261968A1
公开(公告)日：2008-10-23
申请号：US11986626
申请日：2007-11-20
申请人： Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
发明人： Christian Gege , Matthias Schneider , Carine Chevrier , Hongbo Deng , Irving Sucholeiki , Brian M. Gallagher , Michael Bosies , Christoph Steeneck , Xinyuan Wu , Matthias Hochgurtel , Bert Nolte , Arthur Taveras
IPC分类号： A61K31/5375 , C07D239/72 , A61K31/517 , A61K31/52 , C07D413/02 , A61P19/02 , A61K31/519 , C07D473/00 , C07D495/04
CPC分类号： C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要： The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译： 本发明一般涉及含有氮杂双环的药物，特别涉及氮杂双环金属蛋白酶抑制化合物。 更具体地说，本发明提供了一类新的氮杂双环MMP-3，MMP-8和/或MMP-13抑制化合物，其相对于目前已知的MMP-13，MMP-8和MMP- 3抑制剂。
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公开(公告)号：US20070155739A1
公开(公告)日：2007-07-05
申请号：US11646650
申请日：2006-12-28
申请人： Irving Sucholeiki , Timothy Powers , Christian Gege , Harald Bluhm , Rory Dodd , Hongbo Deng , Xinyuan Wu , Christoph Steeneck
发明人： Irving Sucholeiki , Timothy Powers , Christian Gege , Harald Bluhm , Rory Dodd , Hongbo Deng , Xinyuan Wu , Christoph Steeneck
IPC分类号： A61K31/5383 , A61K31/5377 , A61K31/506 , C07D491/02 , C07D413/02 , C07D403/02
CPC分类号： C07D403/12 , C07D239/28 , C07D409/12 , C07D417/12
摘要： This invention relates to substituted bis-amide pyrimidine compounds of Formula (I), which are useful for the treatment of metalloprotease mediated diseases, in particular MMP-13 related diseases.
摘要翻译： 本发明涉及式（I）的取代双酰胺嘧啶化合物，其可用于治疗金属蛋白酶介导的疾病，特别是MMP-13相关疾病。
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