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公开(公告)号：US6110913A
公开(公告)日：2000-08-29
申请号：US55633
申请日：1998-04-06
申请人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Sindelar Karel , Silhankova Alexandra
发明人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Sindelar Karel , Silhankova Alexandra
IPC分类号： A01N43/46 , A61K31/40 , A61K31/44 , A61K31/451 , A61K31/54 , A61P19/02 , C07D207/08 , C07D207/10 , C07D207/12 , C07D211/20 , C07D211/26 , C07D211/70 , C07D223/18 , C07D265/38
CPC分类号： C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5874428A
公开(公告)日：1999-02-23
申请号：US623289
申请日：1996-03-28
申请人： Florenzio Zaragossa D.o slashed.rwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
发明人： Florenzio Zaragossa D.o slashed.rwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
IPC分类号： C07D223/28 , A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/535 , A61K31/538 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02 , A01N43/46 , C07D223/18
CPC分类号： C07D401/06 , C07D207/16 , C07D211/60 , C07D211/62 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5716949A
公开(公告)日：1998-02-10
申请号：US625562
申请日：1996-03-28
申请人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
发明人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D409/06 , C07D417/06 , C07D207/12 , A61K31/38 , A61K31/40 , C07D211/42
CPC分类号： C07D401/06 , C07D211/60 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US6166009A
公开(公告)日：2000-12-26
申请号：US390020
申请日：1999-09-03
申请人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Zdenek Polivka , Alexandra Silhankova , Karel Sindelar
发明人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Zdenek Polivka , Alexandra Silhankova , Karel Sindelar
IPC分类号： A01N43/46 , A61K31/40 , A61K31/44 , A61K31/451 , A61K31/54 , A61P19/02 , C07D207/08 , C07D207/10 , C07D207/12 , C07D211/20 , C07D211/26 , C07D211/70 , C07D223/18 , C07D265/38 , A61K31/645
CPC分类号： C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US5962449A
公开(公告)日：1999-10-05
申请号：US623447
申请日：1996-03-28
申请人： Peter Madsen , Knud Erik Andersen , Rolf Hohlweg , Florenzio Zaragossa Dorwald , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen
发明人： Peter Madsen , Knud Erik Andersen , Rolf Hohlweg , Florenzio Zaragossa Dorwald , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen
IPC分类号： A61K31/195 , A61K31/55 , A61P25/04 , A61P29/00 , C07C227/16 , C07C229/56 , C07D223/28 , C07D401/12 , A01N43/46 , C07D221/06 , C07D265/34 , C07D487/00
CPC分类号： C07D223/28 , C07C229/56 , C07D401/12 , C07C2103/32
摘要： The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代氨基酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床治疗 其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5827856A
公开(公告)日：1998-10-27
申请号：US627750
申请日：1996-04-02
申请人： Knud Erik Andersen , Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Peter Madsen , Henrik Sune Andersen , Uffe Bang Olsen , Polivka Zdenek , Silhankova Alexandra , Sidelar Karel
发明人： Knud Erik Andersen , Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Peter Madsen , Henrik Sune Andersen , Uffe Bang Olsen , Polivka Zdenek , Silhankova Alexandra , Sidelar Karel
IPC分类号： A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/453 , A61K31/4535 , A61K31/473 , A61P3/08 , A61P25/04 , A61P25/06 , A61P29/00 , C07D211/60 , C07D211/78 , C07D405/12 , C07D409/12 , A01N43/42
CPC分类号： C07D211/60 , A61K31/445 , A61K31/453 , A61K31/4535 , A61K31/473
摘要： The present invention provides a novel method for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明提供了一种用于临床治疗疼痛，痛觉过敏和/或炎性病症的新方法，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。
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公开(公告)号：US5753643A
公开(公告)日：1998-05-19
申请号：US862169
申请日：1997-05-22
申请人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
发明人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D409/06 , C07D417/06 , C07D207/12
CPC分类号： C07D401/06 , C07D211/60 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US5846968A
公开(公告)日：1998-12-08
申请号：US863746
申请日：1997-05-27
申请人： Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Henrik Sune Andersen , Rolf Hohlweg , Peter Madsen , Uffe Bang Olsen
发明人： Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Henrik Sune Andersen , Rolf Hohlweg , Peter Madsen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P3/14 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D413/06 , C07D267/20 , C07D281/16
CPC分类号： C07D401/06 , C07D211/60 , C07D413/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US06071901A
公开(公告)日：2000-06-06
申请号：US53339
申请日：1998-04-01
申请人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
发明人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
IPC分类号： A01N43/46 , A61K31/40 , A61K31/44 , A61K31/451 , A61K31/54 , A61P19/02 , C07D207/08 , C07D207/10 , C07D207/12 , C07D211/20 , C07D211/26 , C07D211/70 , C07D223/18 , C07D265/38
CPC分类号： C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids andy esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5780486A
公开(公告)日：1998-07-14
申请号：US863257
申请日：1997-05-27
申请人： Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Henrik Sune Andersen , Rolf Hohlweg , Peter Madsen , Uffe Bang Olsen
发明人： Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Henrik Sune Andersen , Rolf Hohlweg , Peter Madsen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P3/14 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D413/06 , C07D327/08 , C07D339/00
CPC分类号： C07D401/06 , C07D211/60 , C07D413/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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