-
公开(公告)号：US06569979B1
公开(公告)日：2003-05-27
申请号：US09659442
申请日：2000-09-08
IPC分类号： C08G7700
CPC分类号： B82Y30/00 , B05D1/185 , B82Y10/00 , B82Y40/00 , H01L51/0093
摘要： Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
摘要翻译： 公开了未氧化的碳，硅和锗衬底上的化学修饰的表面。 紫外线辐射介导受保护的ω-改性的α-不饱和氨基烯烃（优选）与氢封端的碳，硅或锗表面的反应。 去除保护基产生氨基烷烃改性的硅表面。 这些氨基可以使用双功能交联剂与末端修饰的寡核苷酸偶联，从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。
-
公开(公告)号：US06689858B2
公开(公告)日：2004-02-10
申请号：US09770885
申请日：2001-01-26
申请人： Robert J. Hamers , Wei Cai , Lloyd M. Smith , Todd C. Strother
发明人： Robert J. Hamers , Wei Cai , Lloyd M. Smith , Todd C. Strother
IPC分类号： C08G7700
CPC分类号： B82Y10/00 , B05D1/185 , B82Y30/00 , B82Y40/00 , H01L51/0093
摘要： Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
摘要翻译： 公开了未氧化，溴或碘封端的碳，硅和锗衬底上的化学修饰的表面。 可见光介导受保护的ω-改性的α-不饱和氨基烯烃（优选）与溴或碘封端的碳，硅或锗表面的反应。 去除保护基产生氨基烷烃改性的硅表面。 这些氨基可以使用双功能交联剂与末端修饰的寡核苷酸偶联，从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。
-
公开(公告)号：US07582422B2
公开(公告)日：2009-09-01
申请号：US10269561
申请日：2002-10-11
CPC分类号： B82Y30/00 , B05D1/185 , B82Y10/00 , B82Y40/00 , H01L51/0093
摘要： Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected ω-modified, α-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
摘要翻译： 公开了未氧化的碳，硅和锗衬底上的化学修饰的表面。 紫外线辐射介导受保护的ω-改性的α-不饱和氨基烯烃（优选）与氢封端的碳，硅或锗表面的反应。 保护基团的去除产生氨基烷烃改性的硅表面这些氨基可以使用双官能交联剂与末端修饰的寡核苷酸偶联，从而允许制备改性的表面和阵列。 还公开了用于控制附着于基底的分子的表面密度的方法。
-
公开(公告)号：US09170191B2
公开(公告)日：2015-10-27
申请号：US13931348
申请日：2013-06-28
CPC分类号： G01N21/0303 , G01J3/0202 , G01N21/255 , G01N21/35 , G01N2021/3595 , G01N2201/066
摘要： The present invention is thus directed to an automated system and method of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Such a methodology and system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.
摘要翻译： 因此，本发明涉及一种自动化系统和方法，其改变来自分光光度计的光必须穿过的样品中的光程长度。 这样的布置允许用户容易地改变光路长度，同时还为用户提供了清洁和准备用于光询问的传输单元的简单方法。 这种路径长度控制可以由可编程控制系统自动控制，以便根据不同光谱分析的需要快速收集和存储来自不同路径长度的数据。 如本文所述，这种方法和系统能够以比考虑参考光谱的所有可能组合的方式更少的计算步骤和更高的速度返回最佳匹配光谱。
-
公开(公告)号：US06878523B2
公开(公告)日：2005-04-12
申请号：US10141611
申请日：2002-05-08
申请人： Bryce P. Nelson , Todd C. Strother
发明人： Bryce P. Nelson , Todd C. Strother
CPC分类号： C40B30/04 , B82Y30/00 , G01N33/6845
摘要： The present invention relates to novel methods for the analysis of molecular interactions. In particular, the present invention relates to compositions and methods for molecular interaction assays performed in solution and on solid surfaces. The present invention thus provides improves methods and compositions for the analysis of molecular interactions.
摘要翻译： 本发明涉及分子相互作用分析的新方法。 特别地，本发明涉及在溶液和固体表面上进行的分子相互作用测定的组合物和方法。 因此，本发明提供改进用于分析相互作用分析的方法和组合物。
-
-
-
-
搜索结果
5 条记录 (耗时 0.025 秒)
