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333 条记录 (耗时 0.054 秒)

    Non-nucleoside reverse transcriptase inhibitors
    3.
    发明授权
    Non-nucleoside reverse transcriptase inhibitors 失效
    非核苷逆转录酶抑制剂

    公开(公告)号：US07625897B2

    公开(公告)日：2009-12-01

    申请号：US11541011

    申请日：2006-09-29

    申请人： Yoshihito David Saito ,  Mark Smith ,  Zachary Kevin Sweeney

    发明人： Yoshihito David Saito ,  Mark Smith ,  Zachary Kevin Sweeney

    IPC分类号： C07D253/06 ,  A61K31/53 ,  A61P31/18

    CPC分类号： C07D237/04 ,  C07D237/02 ,  C07D253/06 ,  C07D253/07 ,  C07D273/04

    摘要： The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for methods of treating or preventing HIV infection with compounds according to formula I and compositions containing the same. The invention still further provides process for the preparation of compounds of formula I wherein R4 is A1 and X1 is NH or O.

    摘要翻译： 本发明提供式I化合物，其中R 1至R 4如本文所定义，其可用于治疗或预防人类免疫缺陷病毒（HIV）感染或治疗AIDS或ARC。 本发明进一步提供了用式I化合物和含有该化合物的组合物治疗或预防HIV感染的方法。 本发明还提供制备其中R 4为Al且X 1为NH或O的式I化合物的方法。

    HORIZONTALLY-LINKED REINSURANCE NETWORK
    5.
    发明申请
    HORIZONTALLY-LINKED REINSURANCE NETWORK 审中-公开

    公开(公告)号：US20170206608A1

    公开(公告)日：2017-07-20

    申请号：US15403374

    申请日：2017-01-11

    申请人： Mark Smith

    发明人： Mark Smith

    IPC分类号： G06Q40/08 ,  G06Q40/00 ,  G06Q40/06

    CPC分类号： G06Q40/08 ,  G06Q40/06 ,  G06Q40/10

    摘要： A Horizontally-Linked Reinsurance Network (HLRN) formed of a plurality of small insurance companies (as defined by applicable law, e.g. U.S.C. §831(b)) that is established and managed by a network administrator presents a new approach to harnessing the benefits of small insurance companies while mitigating the drawbacks of small insurance companies. This system uses a rules-based approach and algorithm to select, allocate, optimize and manage the individual risk portfolio of independent small insurance companies so as to preserve their status as a small insurance company while diversifying risk. Further, network administrator will perform the management functions if the HLRN. This allows investors or persons who would not otherwise own an insurance company to invest in a new asset class which by its nature demonstrates a non-correlation to traditional investment markets and carries both unique return and tax properties.

    Leptin Compositions and Methods for Treating Progressive Cognitive Function Disorders Resulting from Accumulation of Neurofibrillary Tangles and Amyloid Beta
    7.
    发明申请
    Leptin Compositions and Methods for Treating Progressive Cognitive Function Disorders Resulting from Accumulation of Neurofibrillary Tangles and Amyloid Beta 审中-公开
    瘦素组合物和方法治疗由神经原纤维缠结和淀粉样蛋白β积累引起的进行性认知功能障碍

    公开(公告)号：US20150038409A1

    公开(公告)日：2015-02-05

    申请号：US14097818

    申请日：2013-12-05

    申请人： Nikolaos Tezapsidis ,  Steven Greco ,  Mark Smith

    发明人： Nikolaos Tezapsidis ,  Steven Greco ,  Mark Smith

    IPC分类号： A61K38/22 ,  A61K31/7056

    CPC分类号： A61K38/22 ,  A61K31/7056 ,  A61K38/2264 ,  A61K45/06 ,  C12Q1/485 ,  G01N33/5058 ,  G01N2800/2821 ,  G01N2800/2828 ,  A61K2300/00

    摘要： The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.

    摘要翻译： 本公开提供了含有瘦素产物的组合物和用于进行性认知障碍的临床治疗和诊断方法的方法。 根据一个方面，所述发明提供了治疗进行性认知障碍的方法。 根据另一方面，本发明提供了一种用于提高有需要的受试者的认知功能的弹性的方法。 根据另一方面，所述发明提供了鉴定用于治疗进行性认知功能障碍疾病或病症的有效治疗剂的方法，所述有效治疗剂由A和BGR的累积，tau的高度磷酸化或神经原纤维缠结的积累中的至少一种引起。

    Tissue harvesting
    8.
    发明授权
    Tissue harvesting 有权
    组织收获

    公开(公告)号：US08795194B2

    公开(公告)日：2014-08-05

    申请号：US12058910

    申请日：2008-03-31

    申请人： Mark Howard ,  Mark Smith

    发明人： Mark Howard ,  Mark Smith

    IPC分类号： A61B10/02 ,  A61M1/00 ,  B01D25/00

    CPC分类号： C12N5/0653 ,  A61B10/025 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B17/3205 ,  A61B2017/00969 ,  A61B2217/005 ,  A61M1/00 ,  A61M1/0056 ,  A61M2202/0014 ,  A61M2202/08

    摘要： The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed.

    摘要翻译： 本公开涉及一种组织收集装置。 所述组织收集装置包括限定入口和出口的壳体，设置在所述壳体内的第一过滤器，设置在所述壳体内的第二过滤器，所述第二过滤器被配置为将通过所述第一过滤器的所需尺寸的组织颗粒隔开， 施加通过壳体施加的抽吸力。 还公开了收获组织的方法。

    Impact and/or vibration absorbent material and protective articles making use thereof
    10.
    发明授权
    Impact and/or vibration absorbent material and protective articles making use thereof 有权
    冲击和/或吸震材料及其使用的保护制品

    公开(公告)号：US08312562B2

    公开(公告)日：2012-11-20

    申请号：US12715263

    申请日：2010-03-01

    申请人： Gary Hammons ,  Roger W. Kramer ,  Charles Marks ,  Kevin Porter ,  Robert Bogard ,  Traci Skahill ,  Mark Smith

    发明人： Gary Hammons ,  Roger W. Kramer ,  Charles Marks ,  Kevin Porter ,  Robert Bogard ,  Traci Skahill ,  Mark Smith

    IPC分类号： A41D19/00

    CPC分类号： A41D31/005 ,  A41D19/01523 ,  A43B13/187 ,  A43B13/189 ,  A47C7/021 ,  B60N2/522 ,  B60N2/525 ,  B60N2/70 ,  F16F3/093 ,  F16F2230/36

    摘要： An impact and/or vibration absorbent material and protective articles making use of said material. An impact and/or vibration absorbent material of the present invention has at least two material layers. The individual layers of the impact and/or vibration absorbent material may be of different materials, or of the same material with the composition of the material of one layer adjusted to be of dissimilar hardness to an adjacent layer. Each material layer preferably contains a number of holes. The holes in one layer are located and arranged to be offset from the holes in an adjacent layer. The combination of material properties and the inclusion and arrangement of holes renders such a material highly impact and/or vibration absorbent. Through use of a protective article of the present invention, the effects of impact and/or vibration forces on a user of the protective article can be minimized.

    摘要翻译： 使用所述材料的冲击和/或振动吸收材料和保护制品。 本发明的冲击和/或振动吸收材料具有至少两个材料层。 冲击和/或振动吸收材料的各个层可以是不同的材料，或者具有相同材料的材料，其中一层材料的组成被调整为与相邻层具有不同的硬度。 每个材料层优选地包含许多孔。 一层中的孔位于并布置成偏离相邻层中的孔。 材料性质的组合和孔的包含和排列使得这种材料具有高度冲击和/或吸振性。 通过使用本发明的保护制品，能够使冲击力和/或振动力对保护用品的使用者的影响最小化。