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1.发明授权Method for measuring a surface plasmon resonance and noble metal compound used for the same 有权用于测量表面等离子体共振的方法和用于其的贵金属化合物公开(公告)号：US07804592B2
公开(公告)日：2010-09-28
申请号：US10575714
申请日：2004-10-12
IPC分类号： G01J3/44
CPC分类号： G01N21/553 , C07D213/38 , G01J3/44 , G01N21/554 , G01N21/658 , G01N33/54373
摘要： The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound. [wherein, X represents a linker group]
摘要翻译： 本发明提供了一种测定表面等离子体共振的方法，该方法能够容易地检测磷酸化肽（蛋白质）的存在并确定生物材料中肽是否被磷酸化。 本发明还提供了与磷酸化肽具有高配位能力的贵金属化合物，并且在该方法中可以方便地使用。 用于测量本发明的表面等离子体共振的第一种方法包括：将贵金属化合物放置在棱镜的底面上，向棱镜照射光以检测反射光，其中贵金属化合物具有下式的取代基 （I）在与棱镜接触的一侧相反的一侧，并且在贵金属化合物中的具有取代基（I）的一侧加入被检样品。 [其中，X表示连接基团]
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2.发明申请Polyacrylamide gel for electrophoresis, polyacrylamide gel electrophoresis method using the same, method of producing the same, and acrylamide compound 有权用于电泳的聚丙烯酰胺凝胶，使用其的聚丙烯酰胺凝胶电泳法，其制备方法和丙烯酰胺化合物公开(公告)号：US20100108515A1
公开(公告)日：2010-05-06
申请号：US11988968
申请日：2005-08-01
申请人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi
发明人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi
IPC分类号： B01D57/02 , C07D213/04
CPC分类号： C07D213/80 , C07D213/82 , C08F220/60 , C08F230/04
摘要： It is intended to provide a method for easily detecting a phosphopeptide (protein) in a test sample by using SDS-poly-acrylamide gel electrophoresis (SDS-PAGE) which has been employed in analyzing a protein, a polyacrylamide gel for electrophoresis to be used in the above method, a method of producing the gel and an intermediate in synthesizing the gel. The polyacrylamide gel for electrophoresis to be used in the above method has a structure represented by the following general formula (I) in at least a part of the structure thereof: (I) wherein M2+ represents a transition metal ion; and X represents a linker.
摘要翻译： 旨在提供一种通过使用已经用于分析蛋白质的SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE），使用用于电泳的聚丙烯酰胺凝胶来测试测试样品中的磷酸肽（蛋白质）的方法 在上述方法中，制备凝胶的方法和合成凝胶的中间体。 在上述方法中使用的用于电泳的聚丙烯酰胺凝胶在其结构的至少一部分中具有由以下通式（I）表示的结构：（I）其中M2 +表示过渡金属离子; X表示连接体。
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3.发明申请Method for measuring a surface plasmon resonance and noble metal compound used for the same 有权用于测量表面等离子体共振的方法和用于其的贵金属化合物公开(公告)号：US20090185181A1
公开(公告)日：2009-07-23
申请号：US10575714
申请日：2004-10-12
IPC分类号： G01J3/44 , C07D213/36 , C07F3/06 , G01N21/55
CPC分类号： G01N21/553 , C07D213/38 , G01J3/44 , G01N21/554 , G01N21/658 , G01N33/54373
摘要： The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound. [wherein, X represents a linker group]
摘要翻译： 本发明提供了一种测定表面等离子体共振的方法，该方法能够容易地检测磷酸化肽（蛋白质）的存在并确定生物材料中肽是否被磷酸化。 本发明还提供了与磷酸化肽具有高配位能力的贵金属化合物，并且在该方法中可以方便地使用。 用于测量本发明的表面等离子体共振的第一种方法包括：将贵金属化合物放置在棱镜的底面上，向棱镜照射光以检测反射光，其中贵金属化合物具有下式的取代基 （I）在与棱镜接触的一侧相反的一侧，并且在贵金属化合物中的具有取代基（I）的一侧加入被检样品。 [其中，X表示连接基团]
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4.发明授权Polyacrylamide gel for electrophoresis, polyacrylamide gel electrophoresis method using the same, method of producing the same, and acrylamide compound 有权用于电泳的聚丙烯酰胺凝胶，使用其的聚丙烯酰胺凝胶电泳法，其制备方法和丙烯酰胺化合物公开(公告)号：US07901559B2
公开(公告)日：2011-03-08
申请号：US11988968
申请日：2005-08-01
申请人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi
发明人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi
IPC分类号： G01N27/26 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/72 , C07D213/78 , C07D471/22
CPC分类号： C07D213/80 , C07D213/82 , C08F220/60 , C08F230/04
摘要： It is intended to provide a method for easily detecting a phosphorylated peptide (protein) in a test sample by using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) which has been conventionally employed in analyzing a protein; a polyacrylamide gel for electrophoresis to be used in the method; a method of producing the gel; and a synthesizing intermediate in producing the gel. The polyacrylamide gel for electrophoresis to be used in the method of the invention is characterized in that at least a part of the structure thereof has a structure represented by the following formula (I); wherein M2+represents a transition metal ion; and X represents a linker group.
摘要翻译： 本发明旨在提供一种通过使用已经用于分析蛋白质的SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）容易地检测测试样品中的磷酸化肽（蛋白质）的方法。 用于电泳的聚丙烯酰胺凝胶用于该方法; 制备凝胶的方法; 以及制造凝胶的合成中间体。 用于本发明方法的电泳用聚丙烯酰胺凝胶的特征在于，其结构的至少一部分具有由下式（I）表示的结构。 其中M2 +表示过渡金属离子; X表示连接基团。
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5.发明授权Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds 有权标记磷酸化肽的方法，选择性吸附磷酸化肽的方法，该方法中使用的复合化合物，复合化合物的制备方法以及配合物的原料化合物公开(公告)号：US07202093B2
公开(公告)日：2007-04-10
申请号：US10784576
申请日：2004-02-23
IPC分类号： G01N33/532 , G01N33/533 , G01N21/76 , G01N33/42 , C07K1/13 , C07D213/00 , G01N24/00 , G01N33/53
CPC分类号： C07F9/6596 , C07D213/38 , G01N33/531 , Y10S435/961 , Y10S436/805 , Y10S436/815 , Y10T436/24
摘要： Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide, and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.
摘要翻译： 提供了一种用于容易地检测来自活生物体等的样品中的磷酸化肽，即蛋白质的方法，用于选择性吸附磷酸化肽的方法，以及与磷酸化肽高配位的化合物，并且可用于该方法。 络合物由下式表示：
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6.发明申请Positron Tomography Method and Positron-Emitting Compound to Be Used Therein 审中-公开正电子断层扫描法和正电子发射化合物公开(公告)号：US20090087378A1
公开(公告)日：2009-04-02
申请号：US12223968
申请日：2007-02-16
申请人： Masaaki Matsuo , Takeru Kitashoji , Tatsuhiro Kobashi , Makoto Takahagi , Hideo Tsukada , Shingo Nishiyama
发明人： Masaaki Matsuo , Takeru Kitashoji , Tatsuhiro Kobashi , Makoto Takahagi , Hideo Tsukada , Shingo Nishiyama
IPC分类号： A61K51/00 , C07D471/08
CPC分类号： C07D471/08 , A61K51/0468
摘要： It is an objective of the present invention to provide a positron tomography method applicable to the diagnosis of specific brain diseases and to provide a positron-emitting compound for use in the method. The present invention method relates to a positron tomography method for measuring a distribution and concentration of a positron-emitting source, and is characterized in using the compound (I) as the positron-emitting source. [wherein, R represents a C1-6 alkyl group or a halogen atom group, having positron-emitting capability]
摘要翻译： 本发明的目的是提供一种适用于特定脑疾病诊断的正电子断层摄影方法，并提供用于该方法的正电子发射化合物。 本发明的方法涉及用于测量正电子发射源的分布和浓度的正电子断层摄影方法，其特征在于使用化合物（I）作为正电子发射源。 [其中，R表示具有正电子发射能力的C 1-6烷基或卤原子基团]
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