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公开(公告)号：US08761883B2
公开(公告)日：2014-06-24
申请号：US13578553
申请日：2011-08-31
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/36507 , A61N1/36585 , A61N1/3684 , A61N1/3702 , A61N1/371
摘要： An implantable medical device is connectable to an epicardial left ventricular lead having at least one epicardial electrode and a myocardium penetrating catheter with at least one endocardial electrode and present in a lumen of the lead. The device comprises a pulse generator controller that controls a ventricular pulse generator to generate pulses to be applied to the epicardial and endocardial electrodes. The controller uses an endocardial-to-epicardial time interval or epicardial-to-endocardial time interval to coordinate endocardial and epicardial activation of the left ventricle to thereby achieve cardiac pacing that closely mimics the natural electrical activation pattern of a healthy heart.
摘要翻译： 可植入医疗装置可连接到具有至少一个心外膜电极的心外膜左心室引线和具有至少一个心内膜电极并存在于引流管腔中的心肌穿透导管。 该装置包括脉冲发生器控制器，其控制心室脉冲发生器以产生要施加到心外膜和心内膜电极的脉冲。 控制器使用心内膜至心外膜时间间隔或心外膜至心内膜时间间隔来协调左心室的心内膜和心外膜激活，从而实现紧密模拟健康心脏的天然电活化模式的心脏起搏。
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公开(公告)号：US20130053917A1
公开(公告)日：2013-02-28
申请号：US13578553
申请日：2011-08-31
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/36507 , A61N1/36585 , A61N1/3684 , A61N1/3702 , A61N1/371
摘要： An implantable medical device is connectable to an epicardial left ventricular lead having at least one epicardial electrode and a myocardium penetrating catheter with at least one endocardial electrode and present in a lumen of the lead. The device comprises a pulse generator controller that controls a ventricular pulse generator to generate pulses to be applied to the epicardial and endocardial electrodes. The controller uses an endocardial-to-epicardial time interval or epicardial-to-endocardial time interval to coordinate endocardial and epicardial activation of the left ventricle to thereby achieve cardiac pacing that closely mimics the natural electrical activation pattern of a healthy heart.
摘要翻译： 可植入医疗装置可连接到具有至少一个心外膜电极的心外膜左心室引线和具有至少一个心内膜电极并存在于引流管腔中的心肌穿透导管。 该装置包括脉冲发生器控制器，其控制心室脉冲发生器以产生要施加到心外膜和心内膜电极的脉冲。 控制器使用心内膜至心外膜时间间隔或心外膜至心内膜时间间隔来协调左心室的心内膜和心外膜激活，从而实现紧密模拟健康心脏的天然电活化模式的心脏起搏。
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3.发明申请公开(公告)号：US20120221071A1
公开(公告)日：2012-08-30
申请号：US13355696
申请日：2012-01-23
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36528 , A61N1/36542 , A61N1/36564 , A61N1/36571 , A61N1/36592
摘要： In an implantable medical device, such as a cardiac stimulator such as a pacemaker, and method for predicting patient responses to physical exertion, the patient response is monitored over time to evaluate disease progression and pacing therapies of cardiac stimulators are adapted based on the predicted patient response. A current cardiac status indicator for the patient is created indicating a response of the patient to an increased physical activity as a primarily heart rate response or as a primarily a stroke volume response. The pacing parameters of the cardiac stimulator can thereafter be adapted depending on the current cardiac status indicator, wherein the adapted pacing parameters include a first pacing setting if the current cardiac status indicator indicates a primarily heart rate response or a second pacing setting if the current cardiac status indicator indicates a primarily stroke volume response.
摘要翻译： 在诸如心脏起搏器等心脏刺激器的可植入医疗装置中，以及用于预测患者对体力消耗的反应的方法，随着时间的推移监视患者反应以评估心脏刺激器的疾病进展和起搏疗法，基于预测患者 响应。 产生患者的当前心脏状态指示符，指示患者作为主要心率反应或作为主要的中风体积响应的增加的身体活动的反应。 心脏刺激器的起搏参数随后可以根据当前的心脏状态指示器进行调整，其中如果当前心脏状态指示符指示主要的心率响应或第二起搏设置，如果当前的心脏 状态指示器表示主要是中风体积响应。
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公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译： 可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。 基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。 针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。 选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。
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公开(公告)号：US20120004700A1
公开(公告)日：2012-01-05
申请号：US13171952
申请日：2011-06-29
IPC分类号： A61N1/368
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译： 可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。 基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。 针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。 选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。
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公开(公告)号：US20130289641A1
公开(公告)日：2013-10-31
申请号：US13997620
申请日：2010-12-23
IPC分类号： A61N1/365
CPC分类号： A61N1/36571 , A61B5/02028 , A61B5/0215 , A61B5/028 , A61B5/029 , A61B5/0472 , A61B5/0538 , A61B5/1116 , A61B5/686 , A61B8/06 , A61B2562/0219 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682
摘要： The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. Hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. At least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals. The at least one hemodynamical index parameter is a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.
摘要翻译： 本发明一般涉及优化患者心脏的刺激的方法和系统。 在不同的血液动力学状态下记录反映患者心脏的机械功能的血液动力学指标信号。 记录相应血液动力学状态下的相应血液动力学参考信号。 从记录的血液动力学指标信号中提取至少一个血液动力学指标参数。 所述至少一个血液动力学指数参数是心脏的机械功能的度量，并且创建血液动力学指标模型，其中所述血液动力学指标模型基于所述至少一个血液动力学指数参数和来自所述血液动力学指标的输出结果之间的比较 模型和相应的血液动力学参考信号。 从该血液动力学指标模型可以得出血流动力学指标，然后可以用于确定心脏刺激器患者定制的心脏起搏设置。
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公开(公告)号：USD678213S1
公开(公告)日：2013-03-19
申请号：US29378436
申请日：2010-11-04
申请人： Andreas Karlsson
设计人： Andreas Karlsson
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8.发明授权Derivatives of 1-OXO-1,2-dihydroisoquinoline-5-carboxamides and of 4-OXO-3,4-dihydroquinazoline-8-carboxamides, preparation thereof and application thereof in therapeutics 失效1-OXO-1,2-二氢异喹啉-5-甲酰胺和4-OXO-3,4-二氢喹唑啉-8-甲酰胺的衍生物，其制备及其在治疗中的应用公开(公告)号：US08030320B2
公开(公告)日：2011-10-04
申请号：US12693598
申请日：2010-01-26
IPC分类号： A61K31/517
CPC分类号： C07D217/24 , C07D239/88
摘要： The present invention relates to compounds of formula I, to the preparation thereof and to the therapeutic use thereof.
摘要翻译： 本发明涉及式I化合物及其制备及其治疗用途。
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公开(公告)号：USD632656S1
公开(公告)日：2011-02-15
申请号：US29294625
申请日：2008-01-18
申请人： Andreas Karlsson
设计人： Andreas Karlsson
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公开(公告)号：US20060153435A1
公开(公告)日：2006-07-13
申请号：US10516800
申请日：2003-06-19
IPC分类号： G06E3/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06K9/34 , G06T7/11 , G06T7/187 , G06T7/64 , G06T2207/10056 , G06T2207/30024
摘要： The present invention relates to the segmentation of two-dimensional gel electrophoresis images (2D images). The method according to the invention associates an initial protein seed candidate with an interface circumscribing said seed and thereafter brings said interface to evolve in accordance with a defined speed function F(x, y). The evolution of the interface is halted by a stopping criterion, C. According to the invention, the speed function can depend on a wide variety of parameters such as the pixel intensity, the curvature of the pixel intensity, the distance to the initial seed, the curvature and/or shape and/or normal direction and/or position of the evolving interface. The stopping criterion depends e.g. on the speed function F and/or the time of arrival T(x, y) and/or the departure time Td for said interface. The invention provides criteria for a specific treatment of saturated spots and to mike sure that interfaces never overlap.
摘要翻译： 本发明涉及二维凝胶电泳图像（2D图像）的分割。 根据本发明的方法将初始蛋白质种子候选物与限定所述种子的界面相关联，然后使所述界面根据定义的速度函数F（x，y）进行演化。 接口的演变由停止标准C停止。根据本发明，速度函数可以取决于各种各样的参数，例如像素强度，像素强度的曲率，到初始种子的距离， 演变界面的曲率和/或形状和/或法线方向和/或位置。 停止标准取决于 对于所述接口，速度函数F和/或到达时间T（x，y）和/或出发时间T 。 本发明提供了对饱和斑点的具体处理的标准，并确保界面不重叠。
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