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    Method for the preparation of 4'-0-tetrahydropyranyladriamycin b
    5.
    发明授权
    Method for the preparation of 4'-0-tetrahydropyranyladriamycin b 失效
    制备4'-O-四氢吡喃阿霉素的方法b

    公开(公告)号：US4818818A

    公开(公告)日：1989-04-04

    申请号：US925774

    申请日：1986-10-30

    申请人： Hamao Umezawa, deceased ,  Tomio Takeuchi ,  Kuniaki Tatsuta ,  Yoshikazu Takahashi

    发明人： Hamao Umezawa, deceased ,  Tomio Takeuchi ,  Kuniaki Tatsuta ,  Yoshikazu Takahashi

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C07H15/24

    CPC分类号： C07H15/252

    摘要： For the preparation of 4'-0-tetrahydropyranyladriamycin b, the 9,14-position of the starting adriamycin is previously protected with phenylboronic acid and then the 4'-position of the thus protected adriamycin is selectively tetrahydropyranylated. After the tetrahydropyranylation, the by-product of 4'-0-tetrahydropyranyladriamycin a is converted to the aimed product of 4'-0-tetrahydropyranyladriamycin b. The yield of the product of 4'-0-tetrahydropyranyladriamycin b is high.The present invention provides a method for the preparation of 4'-0-tetrahydropyranyladriamycin b, where 3,4-dihydro-2H-pyran is added to a reaction solution containing a 9,14-protected adriamycin as obtained by (a) reacting adriamycin and phenyl-boronic acid or (b) reacting 4'-0-tetrahydropyranyladriamycin b and phenylboronic acid in the presence of an acid catalyst, for 4'-tetrahydropyranylation of the said 9,14-protected adriamycin, and then, the 9,14-protected position of the resulting product is deprotected and 4'-0-tetrahydropyranyladriamycin b is isolated by chromatography with silica-gel.

    摘要翻译： 为了制备4'-O-四氢吡喃阿霉素b，起始阿霉素的9,14位预先用苯基硼酸保护，然后由此保护的阿霉素的4'-位选择性地被四氢吡喃基化。 四氢吡喃基化后，4'-O-四氢吡喃阿霉素a的副产物转化为4'-O-四氢吡喃基阿霉素b的目标产物。 4'-O-四氢吡喃阿霉素b的产物的产率高。 本发明提供了制备4'-O-四氢吡喃阿霉素b的方法，其中将3,4-二氢-2H-吡喃加入到含有9,14-保护的阿霉素的反应溶液中，其通过以下步骤获得：（a）使阿霉素 和苯基硼酸或（b）在酸催化剂存在下使4'-O-四氢吡喃阿霉素b和苯基硼酸反应，进行所述9,14受保护的阿霉素的4'-四氢吡喃基化，然后，9,14 将所得产物的保护位置脱保护，并用硅胶色谱分离4'-O-四氢吡喃基阿霉素b。

    Quarantine network system, server apparatus, and program
    6.
    发明授权
    Quarantine network system, server apparatus, and program 有权
    隔离网络系统，服务器设备和程序

    公开(公告)号：US08984634B2

    公开(公告)日：2015-03-17

    申请号：US13616221

    申请日：2012-09-14

    申请人： Yoshikazu Takahashi

    发明人： Yoshikazu Takahashi

    IPC分类号： G06F17/30 ,  G06F12/14 ,  G08B23/00 ,  G06F21/55 ,  G06F21/56 ,  H04L29/06 ,  G06F11/30 ,  H04N7/167

    CPC分类号： G06F21/554 ,  G06F21/56 ,  H04L63/0209 ,  H04L63/145 ,  H04L63/20

    摘要： A quarantine network system 100 quarantines terminals 30 and 31 connected to a network via a wireless communication. The quarantine network system 100 is provided with an access point 20 for a business NW used for connection to a business network, an access point 21 for a quarantine NW which is used for connection to a network for quarantining and restricts the number of terminals connectable thereto, and an NW switching performance server 10 transmitting to the terminal a command which makes the terminal switch SSID of an access point which the terminal uses for wireless communication, in accordance with the situation.

    摘要翻译： 隔离网络系统100通过无线通信隔离连接到网络的终端30和31。 隔离网络系统100设置有用于连接到商业网络的业务NW的接入点20，用于连接到网络以进行隔离的隔离NW的接入点21，并且限制可连接到其的终端的数量 以及NW切换性能服务器10，根据该情况向终端发送使终端用于无线通信的接入点的终端切换SSID的命令。

    Content recommendation system, content recommendation method, content recommendation device, and information storage medium
    7.
    发明授权
    Content recommendation system, content recommendation method, content recommendation device, and information storage medium 有权
    内容推荐系统，内容推荐方法，内容推荐设备和信息存储介质

    公开(公告)号：US08838641B2

    公开(公告)日：2014-09-16

    申请号：US13380528

    申请日：2010-06-08

    申请人： Katsu Saito ,  Masaaki Isozaki ,  Wataru Onogi ,  Kazuo Ishii ,  Nozomu Ikeda ,  Yoshikazu Takahashi

    发明人： Katsu Saito ,  Masaaki Isozaki ,  Wataru Onogi ,  Kazuo Ishii ,  Nozomu Ikeda ,  Yoshikazu Takahashi

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3053 ,  G06F17/30029 ,  G06F17/30053 ,  G06F17/30867

    摘要： The content recommendation system includes a user attribute information acquisition means for acquiring attribute information of a given user, a list acquisition means for acquiring at least one list from among lists of content sequentially generated over time on the basis of the attribute information of the given user acquired by the user attribute information acquisition means, a user preference information acquisition means for acquiring user preference information, which is feature information of content preferred by the given user, a content extraction means for extracting some content from content included in the list acquired by the list acquisition means on the basis of the user preference information acquired by the user preference information acquisition means, and a content presentation means for presenting the content extracted by the content extraction means to the given user.

    摘要翻译： 内容推荐系统包括用于获取给定用户的属性信息的用户属性信息获取装置，用于根据给定用户的属性信息从随机随机地生成的内容的列表中获取至少一个列表的列表获取装置 由用户属性信息获取装置获取的用户偏好信息获取装置，用于获取作为给定用户优选的内容的特征信息的用户偏好信息;内容提取装置，用于从包含在由所述用户属性信息获取装置获取的列表中的内容中提取一些内容; 基于由用户偏好信息获取装置获取的用户偏好信息的列表获取装置，以及用于将由内容提取装置提取的内容呈现给给定用户的内容呈现装置。

    Switching hub, a system, a method of the switching hub and a program thereof
    8.
    发明授权
    Switching hub, a system, a method of the switching hub and a program thereof 有权
    交换集线器，系统，交换集线器的方法及其程序

    公开(公告)号：US08732817B2

    公开(公告)日：2014-05-20

    申请号：US13317292

    申请日：2011-10-14

    申请人： Yoshikazu Takahashi

    发明人： Yoshikazu Takahashi

    IPC分类号： G06F9/00 ,  G06F15/16 ,  G06F17/00

    CPC分类号： H04L63/145 ,  H04L12/4641 ,  H04L63/20

    摘要： A switching hub, system and method for restricting a communication between terminals within a second network isolated form a first network. The terminals are connected to the first network or the second network, wherein a terminal with sufficient security level is connected to the first network and a terminal with insufficient security level is connected to the second network. And a communication between the terminals within the second network is restricted.

    摘要翻译： 一种用于限制第二网络内的终端之间的通信的交换集线器，系统和方法，其形成第一网络。 终端连接到第一网络或第二网络，其中具有足够安全级别的终端连接到第一网络，并且具有不足安全级别的终端连接到第二网络。 并且第二网络内的终端之间的通信受到限制。

    ARTIFICIAL BLOOD VESSEL
    10.
    发明申请
    ARTIFICIAL BLOOD VESSEL 审中-公开
    人造血管

    公开(公告)号：US20120277849A1

    公开(公告)日：2012-11-01

    申请号：US13544334

    申请日：2012-07-09

    申请人： Kazuyoshi TANI ,  Akira Sawada ,  Yoshikazu Takahashi

    发明人： Kazuyoshi TANI ,  Akira Sawada ,  Yoshikazu Takahashi

    IPC分类号： A61F2/06

    CPC分类号： A61F2/064

    摘要： An artificial blood vessel includes one proximal-end and at least one distal-end communicating with the proximal-end, and an inserting port positioned between the proximal-end and the distal-end. The inserting port is provided with a check valve that permits an intravascular curing device to pass through up to the proximal-end and also prevents body fluid from flowing out from the artificial blood vessel. The proximal-end is connected to the ascending aorta and the at least one distal-end is connected to one of the right brachiocephalic arterial trunk, the left common carotid artery, and the left subclavian artery.

    摘要翻译： 人造血管包括一个近端和至少一个与近端连通的远端，以及位于近端和远端之间的插入口。 插入口设置有止回阀，其允许血管内固化装置通过至近端，并且还防止体液从人造血管流出。 近端连接到升主动脉，并且至少一个远端连接到右头臂动脉干，左颈总动脉和左锁骨下动脉之一。