公开(公告)号：US5846977A

公开(公告)日：1998-12-08

申请号：US675385

申请日：1996-07-02

申请人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

发明人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

IPC分类号： A61K31/47 ,  A61K31/4745 ,  A61K31/44

CPC分类号： A61K31/4745 ,  A61K31/47

摘要： Nerve growth factor production accelerating agents containing oxazopyrroloquinolines, pyrroquinolinequinones and/or their esters as active ingredient are provided. As the oxazopyrroloquinolines and their esters exhibit such production accelerating activity, they are suitably utilized for preventing and treating functional disorders of central nervous system, particularly, Alzheimer's dementia, cerebral ischemia and spinal trauma, as well as for functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma and diabetic neurosis. As the pyrroquinolinequinones and their esters exhibit strong nerve growth factor production accelerating activity, they are suitably utilized for preventing and treating functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma, diabetic neurosis, etc.

摘要翻译： 提供含有恶唑吡咯并喹啉，吡咯醌啉醌和/或其酯作为活性成分的神经生长因子生产促进剂。 由于恶唑吡咯并喹啉及其酯类具有这种生产促进活性，因此适用于预防和治疗中枢神经系统功能紊乱，特别是阿尔茨海默氏痴呆，脑缺血和脊髓损伤，以及周围神经系统的功能障碍 ，外周神经系统创伤和糖尿病性神经症。 由于吡咯醌及其酯显示强烈的神经生长因子生产促进活性，因此适用于预防和治疗周围神经系统功能紊乱，特别是周围神经系统创伤，糖尿病性神经症等。

公开(公告)号：US5589481A

公开(公告)日：1996-12-31

申请号：US200912

申请日：1994-02-22

申请人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

发明人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

IPC分类号： A61K31/47 ,  A61K31/4745 ,  A61K31/44

CPC分类号： A61K31/4745 ,  A61K31/47

摘要： Nerve growth factor production accelerating agents containing oxazopyrroloquinolines, pyrroquinolinequinones and/or their esters as active ingredient are provided. As the oxazopyrroloquinolines and their esters exhibit such production accelerating activity, they are suitably utilized for preventing and treating functional disorders of central nervous system, particularly, Alzheimer's dementia, cerebral ischemia and spinal trauma, as well as for functional disorders of Peripheral nervous system, particularly, peripheral nervous system trauma and diabetic neurosis. As the pyrroquinolineguinones and their esters exhibit strong nerve growth factor production accelerating activity, they are suitably utilized for preventing and treating functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma, diabetic neuropathy, etc.

摘要翻译： 提供含有恶唑吡咯并喹啉，吡咯醌啉醌和/或其酯作为活性成分的神经生长因子生产促进剂。 由于恶唑吡咯并喹啉及其酯表现出这种生产促进活性，因此适用于预防和治疗中枢神经系统功能障碍，特别是阿尔茨海默氏痴呆，脑缺血和脊髓创伤，以及外周神经系统的功能障碍 ，外周神经系统创伤和糖尿病性神经症。 由于吡咯喹啉酮及其酯表现出强烈的神经生长因子生产促进活性，因此适用于预防和治疗周围神经系统功能紊乱，特别是周围神经系统创伤，糖尿病性神经病变等。

公开(公告)号：US5429940A

公开(公告)日：1995-07-04

申请号：US060240

申请日：1993-07-12

申请人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

发明人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

IPC分类号： C07D498/14 ,  C12P17/18 ,  A61K31/435 ,  C12P17/16

CPC分类号： C07D498/14 ,  C12P17/188 ,  Y10S435/822 ,  Y10S435/863

摘要： The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines. The thus obtained oxazopyrroloquinolines include novel compounds. The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.

摘要翻译： 本发明提供一种生产恶唑并吡咯并喹啉的方法，其包括培养微生物以产生吡咯并喹啉醌，并向所得的含有吡咯并喹啉醌的培养液中加入α-氨基酸或一甲基胺，并且微生物细胞未分离，从而将吡咯并喹啉醌转化为 对应的恶唑并吡咯啉喹啉。 由此获得的恶唑并吡咯啉喹啉包括新化合物。 本发明还提供了具有优异生理活性的醛糖还原酶抑制剂，糖尿病合并疾病固化剂，免疫增强剂和肝病抑制剂，其含有作为活性成分的恶唑吡咯并喹啉。

公开(公告)号：US4229543A

公开(公告)日：1980-10-21

申请号：US941641

申请日：1978-09-12

申请人： Kenzo Tonomura ,  Teizi Urakami

发明人： Kenzo Tonomura ,  Teizi Urakami

IPC分类号： C12N1/32 ,  C12N1/36 ,  C12N1/16

CPC分类号： C12N1/32

摘要： A process for culturing methanol-utilizing yeasts, wherein a methanol-utilizing yeast is cultured in a medium containing methanol as a main carbon source, using as seeds yeast cells obtained by culturing the yeast in a culture liquor containing methanol at a concentration higher than 0.1 wt. % and not more than 6 wt. %.

摘要翻译： 培养使用甲醇的酵母的方法，其中使用甲醇的酵母在含有甲醇作为主要碳源的培养基中培养，使用通过在含有浓度高于0.1的甲醇的培养液中培养酵母而获得的酵母细胞 重量 ％且不超过6重量％ ％。

公开(公告)号：US5344768A

公开(公告)日：1994-09-06

申请号：US91884

申请日：1993-07-14

申请人： Teizi Urakami

发明人： Teizi Urakami

IPC分类号： C12P17/18 ,  C12N1/20 ,  C12P17/16

CPC分类号： C12P17/182 ,  Y10S435/822 ,  Y10S435/824 ,  Y10S435/874

摘要： Pyrrolo-quinoline quinone (PQQ) is microbiologically produced by culturing a bacterium in a medium containing methanol, methylamine or a mixture thereof as a carbon source and recovering PQQ from the culture medium. The bacteria are strains of Methylobacterium, Ancylobacter, Hyphomicrobium, Xanthobacter, Thiobacillus, Microcyclus and Achromobacter.

摘要翻译： 通过在含有甲醇，甲胺或其混合物作为碳源的培养基中培养细菌并从培养基中回收PQQ来微生物制备吡咯并喹啉醌（PQQ）。 细菌是Methylobacterium，Ancyobacter，Hyphomicrobium，Xanthobacter，Thiobacillus，Microcyclus和Achromobacter的菌株。

公开(公告)号：US5760144A

公开(公告)日：1998-06-02

申请号：US678661

申请日：1996-07-11

申请人： Eiichi Ozeki ,  Jun Nagata ,  Teizi Urakami

发明人： Eiichi Ozeki ,  Jun Nagata ,  Teizi Urakami

IPC分类号： C08L67/04 ,  C08F20/00

CPC分类号： C08L67/04

摘要： Biodegradable polymer blends comprising of a polylactic acid or a copolymer containing lactic acid as the main constituent, and a polyhydroxyalkanoate or a copolymer containing two or more hydroxyalkanoic acids as the constituents; methods for controlling the rate of biodegradation of a polylactic acid or a copolymer containing lactic acid as the main constituent, by blending as above; methods for manufacturing such aliphatic polyester polymer blends; and methods for molding such polymer blends; are provided. The aliphatic polyester polymer blends obtained in the invention are colorless and clear, and have excellent biodegradabilities, as well as excellent mechanical strengths. The blends can be molded similarly as in conventional thermoplastic resins, so that they can be utilized in many industries, without problems in the waste product treatment after the use. Furthermore, molded products with excellent qualities are obtained from the blends, because of their improved moldabilities.

摘要翻译： 包含聚乳酸或含有乳酸为主要成分的共聚物的生物可降解聚合物共混物和含有两种或多种羟基链烷酸作为组分的聚羟基链烷酸酯或共聚物; 通过上述混合来控制聚乳酸或含有乳酸的共聚物作为主要成分的生物降解速率的方法; 制造这种脂族聚酯聚合物共混物的方法; 以及用于模塑这种聚合物共混物的方法; 被提供。 本发明中得到的脂族聚酯聚合物共混物是无色透明的，具有优异的生物降解能力以及优异的机械强度。 共混物可以类似于常规热塑性树脂来模塑，使得它们可以在许多工业中使用，在使用后的废物处理中没有问题。 此外，由于其改进的成型性，从共混物获得具有优良品质的成型产品。

公开(公告)号：US5236930A

公开(公告)日：1993-08-17

申请号：US826220

申请日：1992-01-23

申请人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

发明人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

IPC分类号： C07D498/14 ,  C12P17/18

CPC分类号： C07D498/14 ,  C12P17/188 ,  Y10S435/822 ,  Y10S435/863

摘要： The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines.The thus obtained oxazopyrroloquinolines include novel compounds.The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.

摘要翻译： 本发明提供一种生产恶唑并吡咯并喹啉的方法，其包括培养微生物以产生吡咯并喹啉醌，并向所得的含有吡咯并喹啉醌的培养液中加入α-氨基酸或一甲基胺，并且微生物细胞未分离，从而将吡咯并喹啉醌转化为 对应的恶唑并吡咯啉喹啉。 由此获得的恶唑并吡咯啉喹啉包括新化合物。 本发明还提供了具有优异生理活性的醛糖还原酶抑制剂，糖尿病合并疾病固化剂，免疫增强剂和肝病抑制剂，其含有作为活性成分的恶唑吡咯并喹啉。

公开(公告)号：US5061711A

公开(公告)日：1991-10-29

申请号：US592266

申请日：1990-10-03

申请人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh

发明人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh

IPC分类号： A61K31/47

CPC分类号： A61K31/47

摘要： Disclosed is a method of curing liver diseases by administration of pyrrolo quinoline quinon triesters (PQQ triesters). The PQQ triesters include PQQ triallyl ester and PQQ tribenzyl ester which are novel. The PQQ triesters being ester form, they have no toxicity and can be orally adminstered.

公开(公告)号：US5401778A

公开(公告)日：1995-03-28

申请号：US44386

申请日：1993-04-07

申请人： Yutaka Tokiwa ,  Akira Iwamoto ,  Masahiro Harada ,  Shigeki Imagawa ,  Teizi Urakami

发明人： Yutaka Tokiwa ,  Akira Iwamoto ,  Masahiro Harada ,  Shigeki Imagawa ,  Teizi Urakami

IPC分类号： C08L67/04 ,  C08G63/06 ,  C08G63/08

CPC分类号： C08L67/04

摘要： A biodegradable plastic composition for forming biodegradable shaped bodies which includes a poly-.beta.-hydroxybutyrate having a viscosity of n.sub.A at 185.degree. C. and a polycaprolactone having a viscosity of n.sub.B at 185.degree. C., wherein the poly-.beta.-hydroxybutyrate is present in an amount C.sub.A of 10-45 or 55-85% by weight based on the total weight of the poly-.beta.-hydroxybutyrate and the polycaprolactone, and wherein n.sub.A, n.sub.B and C.sub.A satisfy the following condition:4.times.10.sup.-3 .times.C.sub.A -1.7.ltoreq.log (n.sub.A /n.sub.B).ltoreq.4.times.10.sup.-3 .times.C.sub.A -1.3.

摘要翻译： 一种用于形成可生物降解的成形体的可生物降解的塑料组合物，其包括在185℃下具有nA粘度的聚-β-羟基丁酸酯和在185℃下具有nB粘度的聚己内酯，其中存在聚-β-羟基丁酸酯 基于聚-β-羟基丁酸酯和聚己内酯的总重量，其重量为10-45或55-85重量％，其中nA，nB和CA满足以下条件：4×10-3×CA-1.7 < = log（nA / nB）

公开(公告)号：US5369112A

公开(公告)日：1994-11-29

申请号：US841563

申请日：1992-02-26

申请人： Hiroshi Maeda ,  Takaaki Akaike ,  Hideo Nishigoori ,  Teizi Urakami ,  Chieko Yoshida

发明人： Hiroshi Maeda ,  Takaaki Akaike ,  Hideo Nishigoori ,  Teizi Urakami ,  Chieko Yoshida

IPC分类号： A61K31/47 ,  A61K31/44

CPC分类号： A61K31/47 ,  Y10S514/912

摘要： Pyrrolo quinoline esters, oxazopyrrolo quinolines and esters of oxazopyrrolo quinolines are effective at treating cataracts through their active oxygen scavenging activity.

摘要翻译： 吡咯并喹啉酯，恶唑吡咯喹啉和恶唑并吡咯喹啉的酯通过其活性氧清除活性有效治疗白内障。