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    Microorganism, lipid-modifying agent, and the method of manufacturing 2-acyl lysophospholipids
    1.
    发明授权
    Microorganism, lipid-modifying agent, and the method of manufacturing 2-acyl lysophospholipids 有权
    微生物，脂质改性剂和2-酰基溶血磷脂的制备方法

    公开(公告)号：US07993887B2

    公开(公告)日：2011-08-09

    申请号：US11920856

    申请日：2006-04-11

    申请人： Masaaki Nishihara ,  Masazumi Kamata ,  Kohji Yamaguchi ,  Kazunaga Yazawa

    发明人： Masaaki Nishihara ,  Masazumi Kamata ,  Kohji Yamaguchi ,  Kazunaga Yazawa

    IPC分类号： C12N1/20 ,  C12P7/64 ,  C12N9/20

    CPC分类号： C12N9/20 ,  A23J7/00 ,  A23L33/135 ,  C12P7/6481 ,  C12R1/38 ,  C12Y301/01032

    摘要： The present invention provides a new supply source of phospholipase A1, which is useful for phospholipid modification and lipid biochemical research, and offers a method capable of efficiently manufacturing a large amount of high DHA content phospholipids and lysophospholipids. A novel microorganism HFKI-0020 (FERM AP-20545) of the genus Pseudomonas which produces enzymes with phospholipase A1 activity can be used as a new supply source of enzymes with the phospholipase A1 activity. A lipid-modifying agent containing an effective dose of enzymes with the phospholipase A1 activity produced by those novel microorganisms allows the efficient mass-production of lysophospholipids.

    摘要翻译： 本发明提供磷脂酶A1的新供应源，其可用于磷脂修饰和脂质生物化学研究，并提供能够有效地制造大量高DHA含量磷脂和溶血磷脂的方法。 可以使用产生具有磷脂酶A1活性的酶的假单胞菌属的新型微生物HFKI-0020（FERM AP-20545）作为具有磷脂酶A1活性的酶的新供应源。 含有有效剂量的由这些新型微生物产生的磷脂酶A1活性的酶的脂质改性剂允许有效量产生溶血磷脂。

    Novel microorganism, lipid-modifying agent, and the method of manufacturing 2-acyl lysophospholipids
    4.
    发明申请
    Novel microorganism, lipid-modifying agent, and the method of manufacturing 2-acyl lysophospholipids 有权
    新型微生物，脂质改性剂，以及2-酰基溶血磷脂的制造方法

    公开(公告)号：US20090029428A1

    公开(公告)日：2009-01-29

    申请号：US11920856

    申请日：2006-04-11

    申请人： Masaaki Nishihara ,  Masazumi Kamata ,  Kohji Yamaguchi ,  Kazunaga Yazawa

    发明人： Masaaki Nishihara ,  Masazumi Kamata ,  Kohji Yamaguchi ,  Kazunaga Yazawa

    IPC分类号： C12P7/64 ,  C12N1/20 ,  C12N9/20

    CPC分类号： C12N9/20 ,  A23J7/00 ,  A23L33/135 ,  C12P7/6481 ,  C12R1/38 ,  C12Y301/01032

    摘要： The present invention provides a new supply source of phospholipase A1, which is useful for phospholipid modification and lipid biochemical research, and offers a method capable of efficiently manufacturing a large amount of high DHA content phospholipids and lysophospholipids. A novel microorganism HFKI-0020 (FERM AP-20545) of the genus Pseudomonas which produces enzymes with phospholipase A1 activity can be used as a new supply source of enzymes with the phospholipase A1 activity. A lipid-modifying agent containing an effective dose of enzymes with the phospholipase A1 activity produced by those novel microorganisms allows the efficient mass-production of lysophospholipids.

    摘要翻译： 本发明提供磷脂酶A1的新供应源，其可用于磷脂修饰和脂质生物化学研究，并提供能够有效地制造大量高DHA含量磷脂和溶血磷脂的方法。 可以使用产生具有磷脂酶A1活性的酶的假单胞菌属的新型微生物HFKI-0020（FERM AP-20545）作为具有磷脂酶A1活性的酶的新供应源。 含有有效剂量的由这些新型微生物产生的磷脂酶A1活性的酶的脂质改性剂允许有效量产生溶血磷脂。

    Nerve growth factor production accelerators and compositions for preventing or treating neuronal degeneration
    5.
    发明授权
    Nerve growth factor production accelerators and compositions for preventing or treating neuronal degeneration 失效
    神经生长因子生产促进剂和预防或治疗神经元变性的组合物

    公开(公告)号：US5846977A

    公开(公告)日：1998-12-08

    申请号：US675385

    申请日：1996-07-02

    申请人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

    发明人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

    IPC分类号： A61K31/47 ,  A61K31/4745 ,  A61K31/44

    CPC分类号： A61K31/4745 ,  A61K31/47

    摘要： Nerve growth factor production accelerating agents containing oxazopyrroloquinolines, pyrroquinolinequinones and/or their esters as active ingredient are provided. As the oxazopyrroloquinolines and their esters exhibit such production accelerating activity, they are suitably utilized for preventing and treating functional disorders of central nervous system, particularly, Alzheimer's dementia, cerebral ischemia and spinal trauma, as well as for functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma and diabetic neurosis. As the pyrroquinolinequinones and their esters exhibit strong nerve growth factor production accelerating activity, they are suitably utilized for preventing and treating functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma, diabetic neurosis, etc.

    摘要翻译： 提供含有恶唑吡咯并喹啉，吡咯醌啉醌和/或其酯作为活性成分的神经生长因子生产促进剂。 由于恶唑吡咯并喹啉及其酯类具有这种生产促进活性，因此适用于预防和治疗中枢神经系统功能紊乱，特别是阿尔茨海默氏痴呆，脑缺血和脊髓损伤，以及周围神经系统的功能障碍 ，外周神经系统创伤和糖尿病性神经症。 由于吡咯醌及其酯显示强烈的神经生长因子生产促进活性，因此适用于预防和治疗周围神经系统功能紊乱，特别是周围神经系统创伤，糖尿病性神经症等。

    Nerve growth factor production accelerators and compositions for preventing or treating neuronal degeneration
    6.
    发明授权
    Nerve growth factor production accelerators and compositions for preventing or treating neuronal degeneration 失效
    神经生长因子生产促进剂和预防或治疗神经元变性的组合物

    公开(公告)号：US5589481A

    公开(公告)日：1996-12-31

    申请号：US200912

    申请日：1994-02-22

    申请人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

    发明人： Tomoko Tsuji ,  Kohji Yamaguchi ,  Kiyosi Kondo ,  Teizi Urakami

    IPC分类号： A61K31/47 ,  A61K31/4745 ,  A61K31/44

    CPC分类号： A61K31/4745 ,  A61K31/47

    摘要： Nerve growth factor production accelerating agents containing oxazopyrroloquinolines, pyrroquinolinequinones and/or their esters as active ingredient are provided. As the oxazopyrroloquinolines and their esters exhibit such production accelerating activity, they are suitably utilized for preventing and treating functional disorders of central nervous system, particularly, Alzheimer's dementia, cerebral ischemia and spinal trauma, as well as for functional disorders of Peripheral nervous system, particularly, peripheral nervous system trauma and diabetic neurosis. As the pyrroquinolineguinones and their esters exhibit strong nerve growth factor production accelerating activity, they are suitably utilized for preventing and treating functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma, diabetic neuropathy, etc.

    摘要翻译： 提供含有恶唑吡咯并喹啉，吡咯醌啉醌和/或其酯作为活性成分的神经生长因子生产促进剂。 由于恶唑吡咯并喹啉及其酯表现出这种生产促进活性，因此适用于预防和治疗中枢神经系统功能障碍，特别是阿尔茨海默氏痴呆，脑缺血和脊髓创伤，以及外周神经系统的功能障碍 ，外周神经系统创伤和糖尿病性神经症。 由于吡咯喹啉酮及其酯表现出强烈的神经生长因子生产促进活性，因此适用于预防和治疗周围神经系统功能紊乱，特别是周围神经系统创伤，糖尿病性神经病变等。