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    Therapeutic agent for spinal canal stenosis
    1.
    发明授权
    Therapeutic agent for spinal canal stenosis 有权
    椎管狭窄治疗剂

    公开(公告)号：US06369061B1

    公开(公告)日：2002-04-09

    申请号：US09786050

    申请日：2001-03-21

    申请人： Tomoyuki Maruyama ,  Toru Kawamura ,  Toshiaki Akira ,  Hideaki Kido ,  Norifumi Nakamura

    发明人： Tomoyuki Maruyama ,  Toru Kawamura ,  Toshiaki Akira ,  Hideaki Kido ,  Norifumi Nakamura

    IPC分类号： A61K31501

    CPC分类号： A61K31/501 ,  C07D401/12

    摘要： A therapeutic agent for spinal canal stenosis is provided, which contains a pyridazinone compound of the formula (I) wherein R1, R2 and R3 are each independently a hydrogen atom or a lower alkyl, X is a halogen atom, a cyano or a hydrogen atom, Y is a halogen atom, a trifluoromethyl or a hydrogen atom, and A is a C1-C8 alkylene optionally substituted with a hydroxyl, or its pharmacologically acceptable salt.

    摘要翻译： 提供了一种用于椎管狭窄的治疗剂，其包含式（I）的哒嗪酮化合物，其中R 1，R 2和R 3各自独立地为氢原子或低级烷基，X为卤素原子，氰基或氢原子 Y为卤素原子，三氟甲基或氢原子，A为任选被羟基取代的C1-C8亚烷基，或其药理学上可接受的盐。

    Therapeutic and prophylactic agents for peptic ulcer
    4.
    发明授权
    Therapeutic and prophylactic agents for peptic ulcer 失效
    消化性溃疡的治疗和预防剂

    公开(公告)号：US4888417A

    公开(公告)日：1989-12-19

    申请号：US867169

    申请日：1986-05-27

    申请人： Yusei Shiraga ,  Chikara Fukaya ,  Toshiaki Akira ,  Masakazu Iwai ,  Kazumasa Yokoyama ,  Mamoru Tabata ,  Hiroshi Fukui ,  Shigeo Tanaka ,  Yoshiro Iga ,  Tadakazu Suyama ,  Kanemichi Okano

    发明人： Yusei Shiraga ,  Chikara Fukaya ,  Toshiaki Akira ,  Masakazu Iwai ,  Kazumasa Yokoyama ,  Mamoru Tabata ,  Hiroshi Fukui ,  Shigeo Tanaka ,  Yoshiro Iga ,  Tadakazu Suyama ,  Kanemichi Okano

    IPC分类号： A61K31/12 ,  A61K31/70 ,  A61K36/54 ,  C07C49/242 ,  C07C49/255 ,  C07C49/647 ,  C07C49/743 ,  C07H15/18 ,  C07H15/203 ,  C07H15/207

    CPC分类号： C07C403/08 ,  C07C403/10 ,  C07C403/12 ,  C07H15/18 ,  C07H15/203 ,  C07C2101/16 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A):.dbd.C.dbd.CH--COR.sub.8 (A) or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5 ; R.sub.4 represents OR.sub.7 and the bond between the carbon atoms to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

    摘要翻译： 含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R4代表-OR7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R1和R3都表示氢，R2表示-OR5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，则R 1表示= O，R 2表示氢，R 3表示 -OR 6和X所连接的碳原子和与R 4连接的碳原子之间的键是双键，或其药学上可接受的盐或通式（II）的化合物：（ II）其中R 11表示氢或有机残基，R 12，R 13和R 14各自表示有机残基或其药学上可接受的盐。 通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。

    Method for increasing placental blood flow
    5.
    发明授权
    Method for increasing placental blood flow 失效
    增加胎盘血流量的方法

    公开(公告)号：US5888964A

    公开(公告)日：1999-03-30

    申请号：US637288

    申请日：1996-04-24

    申请人： Hiroshi Shinyama ,  Toshiaki Akira ,  Takeshi Uchida ,  Masahiro Watanabe

    发明人： Hiroshi Shinyama ,  Toshiaki Akira ,  Takeshi Uchida ,  Masahiro Watanabe

    IPC分类号： A61K38/55 ,  A61K38/57 ,  A61P13/02 ,  A61P15/00 ,  A61K38/14 ,  A61K38/36

    CPC分类号： A61K38/57 ,  Y10S514/822 ,  Y10S514/929

    摘要： A method for increasing the placental blood flow, which comprises administering a human-originated antithrombin-III. The human-originated antithrombin-III increases the placental blood flow in mammals and particularly improves intrauterine growth retardation caused by a decreased blood flow. The method is highly safe to the mother and fetus, since it uses human-originated AT-III as an active ingredient, thereby enabling effective and safe treatment of intrauterine growth retardation (IUGR) and the like.

    摘要翻译： 一种增加胎盘血流量的方法，其包括施用人源起始的抗凝血酶III。 人源化的抗凝血酶III可增加哺乳动物的胎盘血流量，特别是改善由血流量减少引起的子宫内生长迟缓。 该方法对母体和胎儿是高度安全的，因为它使用人源AT-III作为活性成分，从而能够有效和安全地治疗子宫内发育迟缓（IUGR）等。