公开(公告)号：US06223594B1

公开(公告)日：2001-05-01

申请号：US09160548

申请日：1998-09-25

申请人： Tomoyuki Takiguchi ,  Ryo Nagasaka ,  Minoru Kondo ,  Yasushi Kohno ,  Makoto Tsunekawa ,  Hideki Koyama

发明人： Tomoyuki Takiguchi ,  Ryo Nagasaka ,  Minoru Kondo ,  Yasushi Kohno ,  Makoto Tsunekawa ,  Hideki Koyama

IPC分类号： G01F168

CPC分类号： G01F1/6842

摘要： A thermal type air flow amount measuring apparatus is provided for measuring, a amount of air flowing in an air flow passage. The apparatus includes a bypass passage unit for bypassing a part of the air flowing through the air flow passage into the bypass passage. A flow amount measuring device is disposed in the bypass passage unit. A throttle unit is disposed upstream of the flow amount measuring device in the bypass passage unit and a support unit is disposed downstream over the throttle unit to support the flow amount measuring unit.

摘要翻译： 设置有用于测量在空气流动通道中流动的空气量的热式空气流量测量装置。 该设备包括旁路通道单元，用于旁路流过通过旁通通道的空气流动通道的空气的一部分。 流量测量装置设置在旁通通路单元中。 节气门单元设置在旁通通路单元中的流量测量装置的上游，并且支撑单元设置在节气门单元的下游，以支撑流量测量单元。

公开(公告)号：US06220090B1

公开(公告)日：2001-04-24

申请号：US09253539

申请日：1999-02-22

申请人： Yasushi Kohno ,  Ryo Nagasaka ,  Minoru Kondo ,  Makoto Tsunekawa ,  Tomoyuki Takiguchi

发明人： Yasushi Kohno ,  Ryo Nagasaka ,  Minoru Kondo ,  Makoto Tsunekawa ,  Tomoyuki Takiguchi

IPC分类号： G01F500

CPC分类号： G01F5/00 ,  G01F1/6842

摘要： An air flow meter disposed in an intake pipe has a bypass member having a U-shaped bypass passage, into which part of air flowing through the intake pipe is introduced. An outflow port disposed at a downstream air side of the bypass passage is surrounded at its three sides by opposing surfaces of a pair of side walls and a wall surface of a partition wall disposed at “an upstream air side of the outflow port”. Further, the outflow port is opened in an air flow direction in the bypass passage and in an air flow direction in the air flow passage. Therefore, air flowing through the bypass passage is partially discharged into the air flow passage through the outflow port gradually before joining main air flow in the air flow passage, thereby restricting decrease in air flow velocity and occurrence of turbulence in the bypass passage.

摘要翻译： 设置在进气管中的空气流量计具有具有U形旁通通路的旁通部件，导入通过进气管的空气的一部分被引入。 设置在旁通通道的下游侧的流出口在其三侧被一对侧壁和设置在“流出口”的上游侧空气侧的分隔壁的壁面的相对面相对地包围。 此外，流出口在旁通通路中的空气流动方向和空气流动通道中的空气流动方向上打开。 因此，流入旁路通路的空气在与空气流路连通的主空气流之前逐渐地通过流出口排出到空气流路内，从而限制旁路通路的空气流速的减小和紊流的发生。

公开(公告)号：US5804718A

公开(公告)日：1998-09-08

申请号：US844779

申请日：1997-04-22

申请人： Ryo Nagasaka ,  Yasushi Kohno ,  Masaaki Konishi ,  Minoru Kondo ,  Katsumi Nakashima

发明人： Ryo Nagasaka ,  Yasushi Kohno ,  Masaaki Konishi ,  Minoru Kondo ,  Katsumi Nakashima

IPC分类号： G01F1/684 ,  G01F5/00

CPC分类号： G01F1/684 ,  G01F1/6842

摘要： An airflow amount measuring body is formed such that two pipes are arranged in parallel and a bypass passage having an inverted U-shape is provided. The passage sectional areas A1, A2 and A3 of an upstream side passage, a turning section and a downstream passage of the bypass passage are set as A1

摘要翻译： 气流量测量体形成为使得两个管平行布置，并且设置具有倒U字形的旁通通道。 上游侧通道，转向部分和旁通通道的下游通道的通道截面积A1，A2和A3被设置为A1 / = 1.14和A3 / A1 > = = 1.20以抑制收缩流。 在文丘里管部分的下游侧的周壁处的流量测量体的下端设有文丘里管部。 在旁路流的下游侧的文丘里管部的周壁的一部分设置通道扩大部，在旁通通路的流出口设置引导旁通流的引导部。

公开(公告)号：US06938473B2

公开(公告)日：2005-09-06

申请号：US10298230

申请日：2002-11-18

申请人： Takao Iwaki ,  Toshiyuki Morishita ,  Yasushi Kohno ,  Hiroyuki Wado ,  Yasushi Goka ,  Makoto Tsunekawa ,  Toshirou Gotou ,  Kiyoyuki Sugiura

发明人： Takao Iwaki ,  Toshiyuki Morishita ,  Yasushi Kohno ,  Hiroyuki Wado ,  Yasushi Goka ,  Makoto Tsunekawa ,  Toshirou Gotou ,  Kiyoyuki Sugiura

IPC分类号： G01F1/684 ,  G01F1/68

CPC分类号： G01F1/6842

摘要： An airflow meter has a membrane type sensor element. The sensor element is supported on a support member so that a sensing surface of the sensor element is in parallel to the airflow direction. The airflow meter has at least one means for protecting the sensor element from dust such as foreign particles. The protecting means is provided with an obstruction member that is disposed upstream or downstream of the sensor element with respect to the airflow direction. The sensor element is hidden behind the obstruction member. The obstruction member has gradually spreading surfaces and gradually converging surfaces along the airflow direction. Alternatively, the protecting means can be provided with a deflector, a cover member, a flow guide member, an inlet or a dust collector.

摘要翻译： 气流计具有膜式传感器元件。 传感器元件支撑在支撑构件上，使得传感器元件的感测表面平行于气流方向。 气流计具有至少一种用于保护传感器元件免受诸如外来颗粒的灰尘的装置。 保护装置设置有相对于气流方向设置在传感器元件的上游或下游的阻塞构件。 传感器元件隐藏在阻塞构件后面。 阻塞构件具有逐渐扩散的表面并沿着气流方向逐渐收敛表面。 或者，保护装置可以设置有偏转器，盖构件，导流构件，入口或集尘器。

公开(公告)号：US08695409B2

公开(公告)日：2014-04-15

申请号：US13596385

申请日：2012-08-28

申请人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

发明人： Yasushi Kohno ,  Takao Ban ,  Hidehito Tsujii

IPC分类号： G01M15/04

CPC分类号： G01F1/6842 ,  G01F1/698 ,  G01F1/6983 ,  G01F5/00

摘要： An air flow rate measuring apparatus includes a heater and a control circuit. The heater heats a part of an intake air sucked into an engine. The control circuit controls an energization of the heater. The heater has a measuring-mode temperature when a flow rate of the intake air is measured. The control circuit has a heat cleaner which temporarily raises a temperature of the heater higher than the measuring-mode temperature when an energization of the air flow rate measuring apparatus is started.

摘要翻译： 空气流量测量装置包括加热器和控制电路。 加热器加热吸入发动机的进气的一部分。 控制电路控制加热器的通电。 当测量进气的流量时，加热器具有测量模式温度。 控制电路具有在开始空气流量测量装置通电时临时使加热器的温度高于测量模式温度的热清洁器。

公开(公告)号：US20130317065A1

公开(公告)日：2013-11-28

申请号：US13980604

申请日：2012-01-24

申请人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

发明人： Kazuya Tatani ,  Atsushi Kondo ,  Tatsuhiro Kondo ,  Naohiro Kawamura ,  Shigeki Seto ,  Yasushi Kohno

IPC分类号： A61K31/4439 ,  C07D401/14 ,  C07D413/14 ,  C07D405/06 ,  C07D417/06 ,  A61K31/506 ,  A61K31/444 ,  A61K31/427 ,  A61K31/41 ,  A61K31/4245 ,  C07D401/06 ,  C07D405/14 ,  C07D409/14 ,  A61K31/404

CPC分类号： A61K31/4245 ,  A61K31/404 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D209/18 ,  C07D401/06 ,  C07D401/14 ,  C07D403/10 ,  C07D405/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D419/14 ,  A61K2300/00

摘要： The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

摘要翻译： 本发明提供了具有EP1受体拮抗作用的本发明通式（I）表示的化合物：其中A表示苯环，吡啶环等; Y1表示C1-6亚烷基等; Y2表示单键等; Z表示-C（= O）-NHSO 2 R 6，酸性5元杂环基等; R1表示氢原子等; R 2表示苯基，5元芳族杂环基等; R3表示卤素原子，C1-6烷氧基等; R 4表示氢原子，卤素原子等; R5表示氢原子等; R6表示C1-6烷基等〕或其药学上可接受的盐。 此外，本发明的化合物（I）可以用作治疗或预防LUTS，特别是OAB的各种症状的药剂。

公开(公告)号：US20100160335A1

公开(公告)日：2010-06-24

申请号：US12452172

申请日：2008-06-18

申请人： Yasushi Kohno ,  Koji Ochiai ,  Satoshi Takita ,  Akihiko Kojima ,  Tomohiko Eiraku ,  Tetsuya Kishi

发明人： Yasushi Kohno ,  Koji Ochiai ,  Satoshi Takita ,  Akihiko Kojima ,  Tomohiko Eiraku ,  Tetsuya Kishi

IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D403/00

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

摘要： It is to provide a novel pyridazinone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1 represents H or C1-6 alkyl, each of R2 and R3 represents H, X, C1-6 alkoxy, Z represents O or S, and A represents AA or BB, wherein AA represents: and BB represents: wherein R4 represents H or C1-6 alkyl, and each of R5 and R6 represents C1-6 alkyl.

摘要翻译： 提供由以下通式（1）表示的新的哒嗪酮衍生物，其可用作药物并具有磷酸二酯酶抑制作用：其中R1表示H或C1-6烷基，R2和R3各自表示H，X C 1-6烷氧基，Z表示O或S，A表示AA或BB，其中AA表示：BB表示：其中R4表示H或C1-6烷基，R5和R6各自表示C1-6烷基。

公开(公告)号：US07703320B2

公开(公告)日：2010-04-27

申请号：US12120517

申请日：2008-05-14

申请人： Junzo Yamaguchi ,  Yasushi Kohno

发明人： Junzo Yamaguchi ,  Yasushi Kohno

IPC分类号： G01F1/68

CPC分类号： G01F1/692

摘要： According to a flow measuring device, first ranges formed by a first plurality of resistors form a single continuous value range on a flow direction coordinate axis. Thus, the first plurality of resistors is limited from being thermally insulated from one another in the flow direction, and thereby detectivity is improved. Also, second ranges formed by a second plurality of resistors form an other single continuous value range on a longitudinal direction coordinate axis. The other continuous value range includes a position that corresponds to a half length of a heating element in a longitudinal direction. As a result, detection difference is obtained at the position, at which a temperature is most optimally detected, and thereby detectivity is further improved.

摘要翻译： 根据流量测量装置，由第一多个电阻器形成的第一范围在流动方向坐标轴上形成单个连续值范围。 因此，第一多个电阻器被限制为在流动方向上彼此热绝缘，从而提高了检测性。 此外，由第二多个电阻器形成的第二范围在纵向坐标轴上形成另一个单个连续值范围。 另一连续值范围包括对应于加热元件在纵向上的半长度的位置。 结果，在最佳检测温度的位置处获得检测差异，从而进一步提高检测性。

公开(公告)号：US20080275008A1

公开(公告)日：2008-11-06

申请号：US12213187

申请日：2008-06-16

申请人： Yasushi Kohno ,  Kiyoaki Tanaka ,  Kazuhiko Kuriyama ,  Wataru Hori

发明人： Yasushi Kohno ,  Kiyoaki Tanaka ,  Kazuhiko Kuriyama ,  Wataru Hori

IPC分类号： A61K31/662

CPC分类号： C07C47/575 ,  C07C45/71 ,  C07F7/1804 ,  C07F9/3826 ,  C07F9/3882 ,  C07F9/4015 ,  C07F9/4056 ,  C07F9/653

摘要： Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

摘要翻译： 氨基膦酸衍生物（例如2-氨基-5- [4-（3-苄氧基苯硫基）-2-氯苯基] -2-甲基戊基膦酸酯单酯）由以下通式（1）表示：作为有效的S1P受体调节剂， 减少副作用。

公开(公告)号：US06694811B2

公开(公告)日：2004-02-24

申请号：US10379938

申请日：2003-03-06

申请人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

发明人： Yasushi Kohno ,  Toshimasa Yamamoto ,  Hiroyuki Wado ,  Tetsuo Yoshioka

IPC分类号： G01F168

CPC分类号： G01F1/6842

摘要： A flow meter is formed with a passage for introducing and carrying air to measure and has a sensing part disposed in the passage for measuring a flow rate of the air. A contraction part is formed on an inner surface of the passage so that the contraction part faces the sensing part. The contraction part narrows the flow of the air flowing near the sensing part. A flat surface of the contraction part is formed in parallel with the surface of the sensing part and at least upstream of the sensing part. Thus, collision of particles against the sensing part and adhesion of contaminants to the sensing pert are inhibited. Meanwhile, the flow rate of the air is measured stably and accurately.

摘要翻译： 流量计形成有用于引入和携带空气进行测量的通道，并且具有设置在通道中的用于测量空气流量的感测部分。 收缩部分形成在通道的内表面上，使得收缩部分面向感测部分。 收缩部分使感应部分附近的空气流动变窄。 收缩部分的平坦表面形成为与感测部分的表面平行并且至少在感测部分的上游。 因此，抑制了颗粒与传感部分的碰撞以及污染物与传感污染物的粘附。 同时，稳定且准确地测量空气的流量。