-
公开(公告)号：US20140296205A1
公开(公告)日：2014-10-02
申请号：US14129177
申请日：2012-06-27
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号： C07D513/04 , G01N33/50 , C12Q1/34
CPC分类号： C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
-
公开(公告)号：US09701693B2
公开(公告)日：2017-07-11
申请号：US14129169
申请日：2012-06-27
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号： C07D513/00 , C07D513/04 , C07H9/06 , C12Q1/37 , C12Q1/34
CPC分类号： C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
-
公开(公告)号：US09120781B2
公开(公告)日：2015-09-01
申请号：US13697179
申请日：2011-05-10
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
IPC分类号： C07D263/56 , C07D263/58 , C07D277/82 , C07D413/04 , C07D417/04 , C07D277/64 , C07D263/52 , C07D277/60
CPC分类号： C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
摘要： The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
-
公开(公告)号：US20130131044A1
公开(公告)日：2013-05-23
申请号：US13697179
申请日：2011-05-10
IPC分类号： C07D417/04 , C07D277/60 , C07D413/04 , C07D263/52
CPC分类号： C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
摘要： The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
-
公开(公告)号：US20140275022A1
公开(公告)日：2014-09-18
申请号：US14129169
申请日：2012-06-27
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold G. Selnick
IPC分类号： C07D513/04 , C12Q1/34
CPC分类号： C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
-
公开(公告)号：US09199949B2
公开(公告)日：2015-12-01
申请号：US14129163
申请日：2012-06-27
IPC分类号： C07D263/58 , C07D413/04 , C07D417/04 , C07D277/60 , A61K31/423 , A61K31/428 , C07D277/82 , C12Q1/37 , C07D263/52
CPC分类号： C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
-
公开(公告)号：US20150045346A1
公开(公告)日：2015-02-12
申请号：US14129163
申请日：2012-06-27
IPC分类号： C07D277/60 , C07D263/52
CPC分类号： C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物的化合物或前药的药物组合物的化合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
-
公开(公告)号：US08901087B2
公开(公告)日：2014-12-02
申请号：US13883811
申请日：2011-11-08
申请人： Jiang Chang , Kun Liu , Ernest J. McEachern , Changwei Mu , Harold G. Selnick , Feng Shi , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou , Yongbao Zhu
发明人： Jiang Chang , Kun Liu , Ernest J. McEachern , Changwei Mu , Harold G. Selnick , Feng Shi , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou , Yongbao Zhu
IPC分类号： C08B37/00 , C07D487/02 , A61K31/70 , A61K31/425 , C07D513/04
CPC分类号： C07D513/04
摘要： The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明涉及用于选择性抑制糖苷酶的化合物，化合物的用途和包含该化合物的药物组合物，以及治疗与O-GlcNAC的缺乏或过度表达有关的疾病和障碍和/或O-GlcNAc的积累或缺陷的方法。
-
公开(公告)号：US09243020B2
公开(公告)日：2016-01-26
申请号：US13997484
申请日：2011-12-21
申请人： Ramesh Kaul , Ernest J. McEachern , Harold G. Selnick , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
发明人： Ramesh Kaul , Ernest J. McEachern , Harold G. Selnick , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
IPC分类号： C08B37/00 , C07D487/02 , A61K31/70 , A61K31/425 , C07H17/00 , C07D513/04 , C07H9/06 , C12Q1/34
CPC分类号： C07H9/06 , C07D513/04 , C07H9/00 , C07H17/00 , C12Q1/34 , G01N2333/924 , G01N2500/04 , G01N2500/20
摘要： The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明提供了具有增强的选择性抑制糖苷酶的通透性的化合物，化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
-
公开(公告)号：US20130296301A1
公开(公告)日：2013-11-07
申请号：US13883811
申请日：2011-11-08
申请人： Jiang Chang , Kun Liu , Ernest J. McEachern , Changwei Mu , Harold G. Selnick , Feng Shi , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou , Yongbao Zhu
发明人： Jiang Chang , Kun Liu , Ernest J. McEachern , Changwei Mu , Harold G. Selnick , Feng Shi , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou , Yongbao Zhu
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
摘要翻译： 本发明涉及用于选择性抑制糖苷酶的化合物，化合物的用途和包含该化合物的药物组合物，以及治疗与O-GlcNAC的缺乏或过度表达有关的疾病和障碍和/或O-GlcNAc的积累或缺陷的方法。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.04 秒)
