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    Methods and compositions for modulating ocular damage
    1.
    发明授权
    Methods and compositions for modulating ocular damage 有权
    用于调节眼部损伤的方法和组合物

    公开(公告)号：US09155790B2

    公开(公告)日：2015-10-13

    申请号：US13698518

    申请日：2011-05-20

    申请人： Tongalp H. Tezel ,  Henry J. Kaplan ,  Robert A. Mitchell ,  John O. Trent

    发明人： Tongalp H. Tezel ,  Henry J. Kaplan ,  Robert A. Mitchell ,  John O. Trent

    IPC分类号： A61K31/517 ,  A61K39/395 ,  A61K31/505 ,  A61K31/53 ,  A61K45/06

    CPC分类号： A61K39/3955 ,  A61K31/505 ,  A61K31/53 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.

    摘要翻译： 提供了用于调节与疾病或病症相关的眼睛损伤和/或损伤事件的方法，包括但不限于与眼部手术相关的创伤。 在一些实施方案中，所述方法包括向受试者施用有效量的迁移抑制因子（MIF）多肽生物活性的调节剂。 还提供了用于调节延缓发作和/或预防眼部疾病发展的严重性的方法，以及调节延缓发作和/或抑制和/或预防眼部疾病的发生的严重性的方法 伤口愈合和/或眼部手术引起的伤口愈合的其他结果，以及调节可以用作组织工程程序的一部分以修正结构，功能和/或细胞的移植细胞的存活，功能和/或分化 眼睛的缺陷。

    METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE
    2.
    发明申请
    METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE 有权
    调节眼损伤的方法和组合物

    公开(公告)号：US20130177552A1

    公开(公告)日：2013-07-11

    申请号：US13698518

    申请日：2011-05-20

    申请人： Tongalp H. Tezel ,  Henry J. Kaplan ,  Robert A. Mitchell ,  John O. Trent

    发明人： Tongalp H. Tezel ,  Henry J. Kaplan ,  Robert A. Mitchell ,  John O. Trent

    IPC分类号： A61K39/395 ,  A61K31/505

    CPC分类号： A61K39/3955 ,  A61K31/505 ,  A61K31/53 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.

    摘要翻译： 提供了用于调节与疾病或病症相关的眼睛损伤和/或损伤事件的方法，包括但不限于与眼部手术相关的创伤。 在一些实施方案中，所述方法包括向受试者施用有效量的迁移抑制因子（MIF）多肽生物活性的调节剂。 还提供了用于调节延缓发作和/或预防眼部疾病发展的严重性的方法，以及调节延缓发作和/或抑制和/或预防眼部疾病的发生的严重性的方法 伤口愈合和/或眼部手术引起的伤口愈合的其他结果，以及调节可以用作组织工程程序的一部分以修正结构，功能和/或细胞的移植细胞的存活，功能和/或分化 眼睛的缺陷。

    Apparatus and method to facilitate laser gyroscope ionization
    8.
    发明授权
    Apparatus and method to facilitate laser gyroscope ionization 失效
    激光陀螺仪电离的装置和方法

    公开(公告)号：US07280218B2

    公开(公告)日：2007-10-09

    申请号：US11030248

    申请日：2005-01-06

    申请人： Robert A. Mitchell ,  Christine E. Geosling ,  Ralph A. Patterson

    发明人： Robert A. Mitchell ,  Christine E. Geosling ,  Ralph A. Patterson

    IPC分类号： G01C19/66

    CPC分类号： G01C19/661

    摘要： An apparatus and method is provided for facilitating ionization of a gas medium of a laser gyroscope. The apparatus and method employ a solid state light emitting device as a start aid for the laser gyroscope. The solid state light emitting device has a wavelength at or below a threshold wavelength based on a work function of a cathode coating material to prompt ionization of a gas medium within the laser gyroscope.

    摘要翻译： 提供了一种用于促进激光陀螺仪的气体介质的离子化的装置和方法。 该装置和方法采用固态发光装置作为激光陀螺仪的启动辅助装置。 固体发光器件具有基于阴极涂层材料的功函数以使激光陀螺仪内的气体介质电离的阈值波长以下的波长。

    Compounds having MIF antagonist activity
    9.
    发明授权
    Compounds having MIF antagonist activity 失效
    具有MIF拮抗剂活性的化合物

    公开(公告)号：US06492428B1

    公开(公告)日：2002-12-10

    申请号：US09625829

    申请日：2000-07-26

    申请人： Yousef Al-Abed ,  Richard J. Bucala ,  Robert A. Mitchell ,  Peter Senter

    发明人： Yousef Al-Abed ,  Richard J. Bucala ,  Robert A. Mitchell ,  Peter Senter

    IPC分类号： A61K3117

    CPC分类号： A61K31/122 ,  A61K31/167

    摘要： There are disclosed methods of use and pharmaceutical compositions for two related genera of low molecular weight compounds comprising optionally substituted iminoquinone or orthoquinone ring systems. The compounds have MIF (macrophage migration inhibitory factor) antagonist activity and find utility as such. For example, the compounds are useful for treating a variety of diseases involving inflammatory activity or pro-inflammatory cytokine responses, such as autoimmune diseases (including rheumatiod arthritis, insulin-dependent diabetes, multiple sclerosis, graft versus host disease, lupus syndromes), asthma, arthritis, EAE, ARDS, psoriasis, interleukin-2 toxicity, proliferative vascular disease, and various forms of sepsis and septic shock, and other conditions characterized by underlying MIF responses including, for instance, tumor growth and neovascularization (angiogenesis).

    摘要翻译： 公开了使用的方法和用于两种相关属的低分子量化合物的药物组合物，其包含任选取代的亚氨基醌或正醌环系。 这些化合物具有MIF（巨噬细胞迁移抑制因子）拮抗剂活性，并发现其效用。 例如，该化合物可用于治疗涉及炎症活性或促炎细胞因子应答的各种疾病，例如自身免疫疾病（包括风湿性关节炎，胰岛素依赖性糖尿病，多发性硬化，移植物抗宿主病，狼疮综合征），哮喘 ，关节炎，EAE，ARDS，牛皮癣，白细胞介素-2毒性，增殖性血管疾病和各种形式的败血症和败血性休克，以及其他由潜在的MIF反应（包括例如肿瘤生长和新生血管形成）（血管发生）表征的病症。

    Inducible phosphofructokinase and the warburg effect
    10.
    发明授权
    Inducible phosphofructokinase and the warburg effect 失效
    诱导型磷酸果糖激酶和warburg效应

    公开(公告)号：US06255046B1

    公开(公告)日：2001-07-03

    申请号：US09183846

    申请日：1998-10-30

    申请人： Richard J. Bucala ,  Jason A. Chesney ,  Robert A. Mitchell

    发明人： Richard J. Bucala ,  Jason A. Chesney ,  Robert A. Mitchell

    IPC分类号： C12Q100

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C12Y207/01105

    摘要： There is disclosed a cancer malignancy diagnostic assay comprising obtaining a sample of a body fluid or tissue, performing a sequence identity assay to look for the presence of iPFK-2 specific sequences; an anticancer pharmaceutical composition comprising a specific antisense oligonucleotide to the inventive isolated iPFK-2 sequence and a pharmaceutically acceptable oligonucleotide carrier; and a method for finding therapeutically active anti-cancer compounds comprising screening compounds for activity to inhibit iPFK-2, preferably kinase activity.

    摘要翻译： 公开了一种癌症恶性肿瘤诊断测定法，其包括获得体液或组织的样品，进行序列同一性测定以寻找iPFK-2特异性序列的存在; 包含本发明的分离的iPFK-2序列的特异性反义寡核苷酸和药学上可接受的寡核苷酸载体的抗癌药物组合物; 以及用于发现治疗活性抗癌化合物的方法，包括筛选用于抑制iPFK-2的活性的化合物，优选激酶活性。