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1.发明授权Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma 有权鉴定食管癌，结肠癌，头颈癌和黑色素瘤中的标志物公开(公告)号：US07662561B2
公开(公告)日：2010-02-16
申请号：US11178134
申请日：2005-07-08
申请人： Tony E. Godfrey , Liqiang Xi , Siva Raja , Steven J. Hughes , William E. Gooding
发明人： Tony E. Godfrey , Liqiang Xi , Siva Raja , Steven J. Hughes , William E. Gooding
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供了用于鉴定指示存在食管，鳞状细胞癌，头颈部鳞状细胞癌，结肠癌和黑素瘤的标志物的表达的方法。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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2.发明申请IDENTIFICATION OF MARKERS IN ESOPHAGEAL CANCER, COLON CANCER, HEAD AND NECK CANCER, AND MELANOMA 审中-公开鉴定标志在食管癌，结肠癌，头颈癌和梅毒公开(公告)号：US20100240037A1
公开(公告)日：2010-09-23
申请号：US12637862
申请日：2009-12-15
申请人： Tony E. Godfrey , Liqiang Xi , Siva Raja , Steven J. Hughes , William E. Gooding
发明人： Tony E. Godfrey , Liqiang Xi , Siva Raja , Steven J. Hughes , William E. Gooding
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供了用于鉴定指示存在食管，鳞状细胞癌，头颈部鳞状细胞癌，结肠癌和黑素瘤的标志物的表达的方法。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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公开(公告)号：US20110312515A1
公开(公告)日：2011-12-22
申请号：US13030003
申请日：2011-02-17
申请人： Tony E. Godfrey , Liqiang Xi , Siva Raja , William E. Gooding
发明人： Tony E. Godfrey , Liqiang Xi , Siva Raja , William E. Gooding
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying expression of markers indicative of the presence of breast cancer and lung cancer are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供了用于鉴定表示存在乳腺癌和肺癌的标志物的表达的方法。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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公开(公告)号：US20060068418A1
公开(公告)日：2006-03-30
申请号：US11178109
申请日：2005-07-08
申请人： Tony Godfrey , Liqiang Xi , Siva Raja , William Gooding
发明人： Tony Godfrey , Liqiang Xi , Siva Raja , William Gooding
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying expression of markers indicative of the presence of breast cancer and lung cancer are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供了用于鉴定表示存在乳腺癌和肺癌的标志物的表达的方法。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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5.发明申请Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma 有权鉴定食管癌，结肠癌，头颈癌和黑色素瘤中的标志物公开(公告)号：US20060019290A1
公开(公告)日：2006-01-26
申请号：US11178134
申请日：2005-07-08
申请人： Tony Godfrey , Liqiang Xi , Siva Raja , Steven Hughes , William Gooding
发明人： Tony Godfrey , Liqiang Xi , Siva Raja , Steven Hughes , William Gooding
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.
摘要翻译： 提供了用于鉴定指示存在食管，鳞状细胞癌，头颈部鳞状细胞癌，结肠癌和黑素瘤的标志物的表达的方法。 还提供了可用于这种方法的制品，和含有可用于这些方法的引物和探针的组合物。
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公开(公告)号：US07101663B2
公开(公告)日：2006-09-05
申请号：US10090326
申请日：2002-03-04
CPC分类号： C12Q1/6851 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/166 , C12Q2537/143 , C12Q2527/107 , C12Q2561/101
摘要： A method for balancing multiplexed PCR methods is provided. In the method, two or more sequential temporal PCR stages are used to effectively separate two or more PCR reactions in a single tube as an alternative to primer limiting to modulate the relative rate of production of a first amplicon by a first primer set and a second amplicon by a second primer set during the first and second amplification stages. Also provided are rapid RT-PCR methods that find particular use in intraoperative diagnoses and prognoses, for instance in diagnosing malignant esophageal adenocarcenoma by determining expression levels of carcinoembryonic antigen (CEA) in sentinel lymph nodes.
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公开(公告)号：US20060205006A1
公开(公告)日：2006-09-14
申请号：US11433722
申请日：2006-05-12
申请人： Tony Godfrey , James Luketich , Siva Raja , Lori Kelly , Sydney Finkelstein
发明人： Tony Godfrey , James Luketich , Siva Raja , Lori Kelly , Sydney Finkelstein
CPC分类号： C12Q1/6851 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/166 , C12Q2537/143 , C12Q2527/107 , C12Q2561/101
摘要： A method for balancing multiplexed PCR methods is provided. In the method, two or more sequential temporal PCR stages are used to effectively separate two or more PCR reactions in a single tube as an alternative to primer limiting to modulate the relative rate of production of a first amplicon by a first primer set and a second amplicon by a second primer set during the first and second amplification stages. Also provided are rapid RT-PCR methods that find particular use in intraoperative diagnoses and prognoses, for instance in diagnosing malignant esophageal adenocarcenoma by determining expression levels of carcinoembryonic antigen (CEA) in sentinel lymph nodes.
摘要翻译： 提供了一种平衡复用PCR方法的方法。 在该方法中，使用两个或多个连续的时间PCR阶段来有效地分离单个管中的两个或更多个PCR反应，作为引物限制的替代，以调节第一引物组和第二引物组的相对生产速率 在第一和第二扩增阶段期间由第二引物组扩增。 还提供了快速RT-PCR方法，其特别用于术中诊断和预后，例如通过确定前哨淋巴结中癌胚抗原（CEA）的表达水平来诊断恶性食管腺癌。
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