公开(公告)号：US20060211137A1

公开(公告)日：2006-09-21

申请号：US11362354

申请日：2006-02-27

申请人： Toshihide Ezoe ,  Toshiaki Kubo ,  Masashi Hakamata

发明人： Toshihide Ezoe ,  Toshiaki Kubo ,  Masashi Hakamata

IPC分类号： G01N33/543 ,  C12M1/34

CPC分类号： G01N33/54373

摘要： It is an object of the present invention to provide a biosensor wherein a reference unit and a measurement unit can be prepared by performing only a single operation for immobilizing a physiologically active substance and wherein unnecessary electric charge does not remain in the reference unit. The present invention provides a biosensor which comprises a substrate composed of a metal surface or metal film coated with a hydrophilic polymer compound, and which has a surface for retaining a physiologically active substance and a surface that does not retain a physiologically active substance on a single plane of the substrate.

摘要翻译： 本发明的目的是提供一种生物传感器，其中通过仅执行用于固定生理活性物质的单一操作并且其中不必要的电荷不残留在参考单元中，可以制备参考单元和测量单元。 本发明提供了一种生物传感器，其包括由涂覆有亲水性高分子化合物的金属表面或金属膜构成的基板，并且具有用于保持生理活性物质的表面和不保留生理活性物质的表面 基板的平面。

公开(公告)号：US20070243633A1

公开(公告)日：2007-10-18

申请号：US11237867

申请日：2005-09-29

申请人： Masashi Hakamata ,  Toshiaki Kubo

发明人： Masashi Hakamata ,  Toshiaki Kubo

IPC分类号： G01N33/543 ,  C12M3/00

CPC分类号： G01N33/545

摘要： An object of the present invention is to provide a biosensor which exhibits good reproducibility of the amount of an immobilized physiologically active substance by suppressing plane deterioration (separation of a metal film from a resin) which occurs at the formation of a thin metal film layer on a resin surface. The present invention provides a biosensor which is produced by performing plasma irradiation on a light-reflecting surface of an optical block which is obtained by molding a resin and has at least 3 surfaces including a light incident surface, the light-reflecting surface and a light-emerging surface; forming a first metal layer; and then forming a second metal layer on the side of the first metal layer which is opposite to the light-reflecting surface.

摘要翻译： 本发明的目的是提供一种生物传感器，其通过抑制在形成薄金属膜层时发生的平面退化（金属膜与树脂的分离）而使固定的生理活性物质的重复性良好 树脂表面。 本发明提供一种生物传感器，其通过对通过模制树脂获得的光学块的光反射表面进行等离子体照射而制造，并且具有包括光入射面，光反射表面和光的至少3个表面 出现表面; 形成第一金属层; 然后在第一金属层的与光反射表面相对的一侧上形成第二金属层。

公开(公告)号：US06066858A

公开(公告)日：2000-05-23

申请号：US982102

申请日：1997-11-17

申请人： Motoko Kawasaki ,  Katsumi Hayashi ,  Masashi Hakamata ,  Keiji Mori

发明人： Motoko Kawasaki ,  Katsumi Hayashi ,  Masashi Hakamata ,  Keiji Mori

IPC分类号： G01N33/60 ,  G03B42/00

CPC分类号： G01N33/60

摘要： An autoradiographic process for obtaining locational information on two or more radioactively labeled substances which have different energy or half-life and are contained in a sample such as tissue of an organism. Specifically, the process includes the steps of placing the sample on a stimulable phosphor sheet having a plastic cover layer to cause the stimulable phosphor to absorb radiation energy of the labeled substances and reading the absorbed radiation energy out of the phosphor to obtain an image signal corresponding to one radioactively labeled substance and placing the sample on a stimulable phosphor sheet having a thinner plastic cover layer or no cover film to cause the stimulable phosphor to absorb radiation energy of the labeled substances and reading the absorbed radiation energy out of the phosphor to obtain image signals corresponding to plural radioactively labeled substances. Then, the process includes the step of subjecting the image signals of (a) and (b) to subtraction processing so that image signals corresponding to plural radioactively labeled substances can be separately obtained.

摘要翻译： 一种放射自显影方法，用于获得具有不同能量或半衰期并且包含在诸如生物体的组织的样品中的两种或更多种放射性标记物质的位置信息。 具体而言，该方法包括以下步骤：将样品放置在具有塑料覆盖层的可刺激的荧光体片上，以使可刺激的荧光体吸收标记物质的辐射能量并从磷光体中读出吸收的辐射能量，以获得相应的图像信号 一种放射性标记的物质，并将样品放置在具有较薄塑料覆盖层或不具有覆盖膜的可刺激的荧光粉片上，以使可刺激的荧光体吸收标记物质的辐射能并从磷光体中读出吸收的辐射能量以获得图像 对应于多个放射性标记物质的信号。 然后，该处理包括对（a）和（b）的图像信号进行减法处理，从而可以分别获得与多个放射性标记物质对应的图像信号。

公开(公告)号：US08749787B2

公开(公告)日：2014-06-10

申请号：US13045361

申请日：2011-03-10

申请人： Junpei Shiraishi ,  Masashi Hakamata

发明人： Junpei Shiraishi ,  Masashi Hakamata

IPC分类号： G01N21/00

CPC分类号： G01N21/648 ,  G01N21/6428

摘要： Excitation light beam is irradiated onto a test region while shifting the irradiation position thereof, when performing analysis of a target substance using an analysis chip having the test region within a flow channel through which a sample solution is caused to flow, for capturing the target substance within the sample solution. Fluorescence generated at the test region is detected as a plurality of adjustment fluorescence signals. The target substance is analyzed using fluorescence generated when the excitation light beam is irradiated at an irradiation position within the test region determined based on the plurality of adjustment fluorescence signals.

摘要翻译： 激发光束在移动其照射位置的同时照射到测试区域上，当使用具有测试区域的分析芯片进行目标物质的分析时，所述测试区域在通过其的样品溶液流过的流动通道内，用于捕获目标物质 在样品溶液中。 在测试区域产生的荧光被检测为多个调节荧光信号。 使用在基于多个调整荧光信号确定的测试区域内的照射位置照射激发光束时产生的荧光来分析目标物质。

公开(公告)号：US06707058B2

公开(公告)日：2004-03-16

申请号：US10022807

申请日：2001-12-20

申请人： Taizo Akimoto ,  Masashi Hakamata

发明人： Taizo Akimoto ,  Masashi Hakamata

IPC分类号： G02B2602

CPC分类号： G03B42/08

摘要： A stimulable phosphor sheet stored thereon a radiation image is two-dimensionally scanned by a stimulating light beam by projecting the light beam along a main scanning line extending in a main scanning direction and moving one of the stimulable phosphor sheet and the stimulating light beam in a sub-scanning direction relatively to the other so that the stimulable phosphor sheet is exposed to the stimulating light beam along a plurality of main scanning lines arranged in the sub-scanning direction at a predetermined pitch and stimulated emission emitted from the part of the stimulable phosphor sheet exposed to the stimulating light beam is photoelectrically converted to an electric image signal by a photoelectric convertor. The power of the stimulating light beam is controlled depending on the pitch at which the main scanning lines are arranged in the sub-scanning direction.

摘要翻译： 通过沿着主扫描方向延伸的主扫描线投射光束，通过刺激光束对存储有放射线图像的可刺激的荧光体片进行二维扫描，并将可激发的荧光体片和刺激光束中的一个移动到 副扫描方向相对于另一方，使得可刺激的荧光体片沿预定间距沿副扫描方向布置的多个主扫描线暴露于刺激光束，并且从可刺激荧光体的一部分发射的受激发射 暴露于刺激光束的片被光电转换器光电转换成电图像信号。 刺激光束的功率根据主扫描线沿副扫描方向排列的间距来控制。

公开(公告)号：US07830521B2

公开(公告)日：2010-11-09

申请号：US11864711

申请日：2007-09-28

申请人： Hiroaki Yamamoto ,  Toshihito Kimura ,  Hitoshi Shimizu ,  Masashi Hakamata

发明人： Hiroaki Yamamoto ,  Toshihito Kimura ,  Hitoshi Shimizu ,  Masashi Hakamata

IPC分类号： G01N21/00

CPC分类号： G01N21/553 ,  G01N2021/157

摘要： Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.

摘要翻译： 提供了能够检测精度降低的检测装置，检测方法和光学透明构件。 通过包含在图像处理部分38中的卷积部分80执行卷积，以获取指示在该界面处被全反射并以多个角度入射的光束的光强度分布的分布信息 介质块52，以便在介质块52的界面处被全反射。通过由图像处理部分38中包含的检测精度评估部分86对由所获取的分布信息指示的光强度分布执行空间频率分辨率 ，从而导出光束的每个空间频率的光强度分布。 通过将导出的光强度分布与针对每个空间频率预定的阈值进行比较来检测精度。

公开(公告)号：USD561624S1

公开(公告)日：2008-02-12

申请号：US29266471

申请日：2006-09-22

申请人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Masashi Hakamata ,  Hideyuki Morimoto ,  Hiroyuki Ota

设计人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Masashi Hakamata ,  Hideyuki Morimoto ,  Hiroyuki Ota

公开(公告)号：USD561623S1

公开(公告)日：2008-02-12

申请号：US29266470

申请日：2006-09-22

申请人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Hitoshi Shimizu ,  Masashi Hakamata ,  Yasunobu Sakaguchi ,  Hideyuki Morimoto ,  Hiroyuki Ota ,  Masayasu Konishi ,  Yoshiyuki Kunuki

设计人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Hitoshi Shimizu ,  Masashi Hakamata ,  Yasunobu Sakaguchi ,  Hideyuki Morimoto ,  Hiroyuki Ota ,  Masayasu Konishi ,  Yoshiyuki Kunuki

公开(公告)号：USD561053S1

公开(公告)日：2008-02-05

申请号：US29266439

申请日：2006-09-21

申请人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Hitoshi Shimizu ,  Masashi Hakamata ,  Yasunobu Sakaguchi ,  Yoshiyuki Kunuki

设计人： Nobuhiko Ogura ,  Katsuaki Muraishi ,  Hitoshi Shimizu ,  Masashi Hakamata ,  Yasunobu Sakaguchi ,  Yoshiyuki Kunuki

公开(公告)号：US20070259193A1

公开(公告)日：2007-11-08

申请号：US11362741

申请日：2006-02-28

申请人： Yukou Saito ,  Masashi Hakamata

发明人： Yukou Saito ,  Masashi Hakamata

IPC分类号： B05D3/12

CPC分类号： G01N21/553 ,  Y10T428/31511 ,  Y10T428/31692 ,  Y10T428/31855

摘要： It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.

摘要翻译： 本发明的目的是提供一种用于制造具有薄膜厚度分布薄膜的传感器的固体基板的制造方法，以及用于具有薄膜厚度分布薄膜的传感器的固体表面。 本发明提供了一种用于制造传感器的固体基板的方法，该传感器在旋转涂层的表面上具有涂层，其中待涂布的基材在涂布溶剂的蒸气压为50％至100％的气氛中旋转， 相对于饱和蒸气压，以便在待涂覆的基底上形成涂层溶液的薄膜。