公开(公告)号：US5290679A

公开(公告)日：1994-03-01

申请号：US898681

申请日：1992-06-15

申请人： Toshihiko Terao ,  Naohiro Kanayama ,  Akihiro Morioka ,  Yoshika Yasuda ,  Masami Kamiya ,  Juichi Awaya ,  Masayasu Kurono ,  Kiichi Sawai

发明人： Toshihiko Terao ,  Naohiro Kanayama ,  Akihiro Morioka ,  Yoshika Yasuda ,  Masami Kamiya ,  Juichi Awaya ,  Masayasu Kurono ,  Kiichi Sawai

IPC分类号： A61K49/00 ,  G01N33/573 ,  C12Q1/00 ,  C12Q1/37

CPC分类号： G01N33/573

摘要： Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex. It is thus possible to predict and prevent threatened premature delivery, premature delivery or premature rupture of membranes by immunoassay of mucus collected from the cervical canal of a pregnant woman, to make a diagnosis of chronic or repetitive airway infections and pulmonary emphysema based on chronic respiratory diseases by immunoassay of sputum and a rinsed solution of bronchovesicular lavage and to make a diagnosis of urinary tract infections by immunoassay of urine.

摘要翻译： 即使样品含有游离弹性蛋白酶与弹性蛋白酶抑制剂复合物或复合物的混合物形式的人粒细胞弹性蛋白酶，本发明能够精确地检测该样本中弹性蛋白酶的总量。 将抑制剂加入到游离弹性蛋白酶中以将其转化成弹性蛋白酶抑制剂复合物，由此弹性蛋白酶的量可以通过免疫测定来测量，包括先前存在的弹性蛋白酶抑制剂复合物的总量。 可以精确测量从孕妇，痰液或冲洗的支气管泡灌洗液的宫颈管中收集的弹性蛋白酶的总量，其中游离弹性蛋白酶与弹性蛋白酶抑制剂复合物混合。 因此，可以通过从孕妇的宫颈管收集的粘液的免疫测定来预测和预防受威胁的早产，早产或过早破裂，以诊断慢性或重复性气道感染和基于慢性呼吸的肺气肿 通过免疫测定痰液的疾病和支气管泡灌洗液的清洗溶液，并通过免疫测定尿液来诊断尿路感染。

公开(公告)号：US06197291B1

公开(公告)日：2001-03-06

申请号：US09043974

申请日：1998-10-14

申请人： Toshihiko Terao ,  Naohiro Kanayama

发明人： Toshihiko Terao ,  Naohiro Kanayama

IPC分类号： A61K3819

CPC分类号： A61K38/2053 ,  Y10S514/885 ,  A61K2300/00

摘要： The inventors provide an agent for potentiating the effect of interleukin-8, which comprises dehydroepiandrosterone sulfate or a pharmaceutically acceptable salt thereof as an active ingredient. An agent for potentiating the effect of IL-8 of the present invention potentiates the effect of IL-8 by activating the receptor of IL-8 and increasing the number of receptors.

摘要翻译： 发明人提供了增强白细胞介素-8的作用的试剂，其包括硫酸脱氢表雄酮或其药学上可接受的盐作为活性成分。 增强本发明IL-8作用的药剂通过激活IL-8受体和增加受体数来增强IL-8的作用。

公开(公告)号：US5650394A

公开(公告)日：1997-07-22

申请号：US148160

申请日：1993-11-04

申请人： Toshihiko Terao ,  Naohiro Kanayama ,  David Casal

发明人： Toshihiko Terao ,  Naohiro Kanayama ,  David Casal

IPC分类号： G01N33/50 ,  A61K31/135 ,  A61K31/405 ,  A61K31/43 ,  A61K31/545 ,  A61K31/70 ,  A61K33/06 ,  A61K38/00 ,  A61K38/55 ,  A61K38/57 ,  A61P13/02 ,  A61P15/00 ,  C07K14/81 ,  C12P21/02 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543

CPC分类号： C07K14/8114 ,  A61K38/57

摘要： The present invention provides a method of diagnosing and treating a pregnant female at risk for impending preterm delivery. The method comprises the step of diagnosing imminent preterm delivery by testing with a method that has a sensitivity of at least 80% and a specificity of at least 80%, or by testing for fetal fibronectin in the female's vaginal or cervical secretions. If imminent preterm delivery is indicated by the test, the next step comprises administering to the female a combination of a tocolytic agent, at least one urinastatin-like compound, and at least one antibiotic. Also provided is a pharmaceutical composition of MGMTSRYFYNGTSMA (SEQ ID NO:1), RAFIQLWAFDAVKGK (SEQ ID NO:2) and an antibiotic.

摘要翻译： 本发明提供了一种诊断和治疗即将到来的早产的风险的怀孕女性的方法。 该方法包括通过使用灵敏度至少为80％，特异性至少为80％的方法或通过在女性阴道或宫颈分泌物中测试胎儿纤连蛋白来测试即将来临的早产的方法。 如果试验指示即将来临的早产，则下一步骤包括向女性施用一种溶瘤剂，至少一种尿囊素样化合物和至少一种抗生素的组合。 还提供了MGMTSRYFYNGTSMA（SEQ ID NO：1），RAFIQLWAFDAVKGK（SEQ ID NO：2）和抗生素的药物组合物。

公开(公告)号：US6013252A

公开(公告)日：2000-01-11

申请号：US817941

申请日：1997-06-05

申请人： Toshihiko Terao ,  Naohiro Kanayama ,  Masanobu Naruto ,  Tatsuya Kaneko

发明人： Toshihiko Terao ,  Naohiro Kanayama ,  Masanobu Naruto ,  Tatsuya Kaneko

IPC分类号： A61K38/16 ,  A61K38/19 ,  A61K38/20 ,  A61K45/05 ,  A01N37/18

CPC分类号： A61K38/195 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/2053 ,  A61K38/217

摘要： Leukocyte chemotactic factors such as interleukin-8 and MCAF, and inductive substances therefor were revealed to have proconceptive activities. These activities include promoting ovum growth and fertilized ovum implantation, and are exhibited by a sole substance. Accordingly, it has been shown that such substances can be used in drugs concerning medical treatment for infertility, and further, can be used in veterinary and livestock industry fields such as reproduction of industrial animals or species preservation of rare animals.

摘要翻译： PCT No.PCT / JP96 / 02412 Sec。 371日期：1997年6月5日 102（e）日期1996年6月5日PCT 1996年8月28日PCT公布。 出版物WO97 / 07813 日期1997年3月6日白细胞趋化因子如白细胞介素-8和MCAF及其诱导物质显示具有反潜活性。 这些活动包括促进卵子生长和受精卵子植入，并由单一物质展示。 因此，已经表明，这些物质可以用于不育医疗的药物中，并且还可以用于兽医和畜牧业领域，例如工业动物的繁殖或稀有动物的物种保存。

公开(公告)号：US20140039284A1

公开(公告)日：2014-02-06

申请号：US14001384

申请日：2012-02-23

申请人： Masatsugu Niwayama ,  Naohiro Kanayama ,  Kazunao Suzuki

发明人： Masatsugu Niwayama ,  Naohiro Kanayama ,  Kazunao Suzuki

IPC分类号： A61B5/00 ,  A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/14551 ,  A61B5/4872 ,  A61B2562/0242 ,  G01N21/4738 ,  G01N21/49 ,  G01N2021/4742

摘要： An accurate measurement can be made of the light absorbance of deep layer tissue such as in a human body or a fruit. The thickness of fat is computed. A first specific distance and a second specific distance corresponding to the computed fat thickness are computed based a predetermined relationship between the fat thickness, the first specific distance, and measurement sensitivity of a surface layer and measurement sensitivity of a deep layer when light is received at a position the first specific distance away from a light emitting means. A third specific distance and a fourth specific distance are computed corresponding to the computed fat thickness based on a predetermined relationship between the fat thickness, the third specific distance and a measurement sensitivity of an intervening layer and a measurement sensitivity of the deep layer when light is received at a position the third specific distance away from the light emitting means.

摘要翻译： 可以精确地测量诸如在人体或水果中的深层组织的光吸收。 计算脂肪的厚度。 基于计算出的脂肪厚度的第一特定距离和第二特定距离是基于脂肪厚度，第一特定距离和表面层的测量灵敏度之间的预定关系以及在深度接收光时的深层的测量灵敏度来计算的 距离发光装置的第一特定距离的位置。 基于脂肪厚度，第三特定距离和中间层的测量灵敏度之间的预定关系以及当深度为深层时的深层的测量灵敏度来计算与计算出的脂肪厚度相对应的第三特定距离和第四具体距离 在远离发光装置的第三特定距离的位置处接收。

公开(公告)号：US20080139804A1

公开(公告)日：2008-06-12

申请号：US11795160

申请日：2006-01-13

申请人： Naohiro Kanayama ,  Kentaro Horiuchi ,  Hidechika Ozawa ,  Toru Hirano ,  Eiji Kohno

发明人： Naohiro Kanayama ,  Kentaro Horiuchi ,  Hidechika Ozawa ,  Toru Hirano ,  Eiji Kohno

IPC分类号： C07D487/22

CPC分类号： C07D487/22 ,  A61K41/0071

摘要： To provide a novel photosensitive compound which is useful for a photodynamic therapy, an agent for the photodynamic therapy containing the same and a method for producing the same. A compound represented by the following formula 1 or pharmaceutically acceptable salts thereof.

摘要翻译： 为了提供可用于光动力学治疗的新颖的光敏化合物，包含其的光动力学治疗剂及其制备方法。 由下式1表示的化合物或其药学上可接受的盐。

公开(公告)号：US09433352B2

公开(公告)日：2016-09-06

申请号：US14001384

申请日：2012-02-23

申请人： Masatsugu Niwayama ,  Naohiro Kanayama ,  Kazunao Suzuki

发明人： Masatsugu Niwayama ,  Naohiro Kanayama ,  Kazunao Suzuki

IPC分类号： A61B5/1455 ,  A61B5/00 ,  G01N21/47 ,  G01N21/49

CPC分类号： A61B5/0059 ,  A61B5/14551 ,  A61B5/4872 ,  A61B2562/0242 ,  G01N21/4738 ,  G01N21/49 ,  G01N2021/4742

摘要： An accurate measurement can be made of the light absorbance of deep layer tissue such as in a human body or a fruit. The thickness of fat is computed. A first specific distance and a second specific distance corresponding to the computed fat thickness are computed based a predetermined relationship between the fat thickness, the first specific distance, and measurement sensitivity of a surface layer and measurement sensitivity of a deep layer when light is received at a position the first specific distance away from a light emitting means. A third specific distance and a fourth specific distance are computed corresponding to the computed fat thickness based on a predetermined relationship between the fat thickness, the third specific distance and a measurement sensitivity of an intervening layer and a measurement sensitivity of the deep layer when light is received at a position the third specific distance away from the light emitting means.

摘要翻译： 可以精确地测量诸如在人体或水果中的深层组织的光吸收。 计算脂肪的厚度。 基于计算出的脂肪厚度的第一特定距离和第二特定距离是基于脂肪厚度，第一特定距离和表面层的测量灵敏度之间的预定关系以及在深度接收光时的深层的测量灵敏度来计算的 距离发光装置的第一特定距离的位置。 基于脂肪厚度，第三特定距离和中间层的测量灵敏度之间的预定关系以及当深度为深层时的深层的测量灵敏度来计算与计算出的脂肪厚度相对应的第三特定距离和第四具体距离 在远离发光装置的第三特定距离的位置处接收。