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    Transdermal patch
    1.
    发明申请
    Transdermal patch 审中-公开
    透皮贴片

    公开(公告)号：US20090258063A1

    公开(公告)日：2009-10-15

    申请号：US12310840

    申请日：2007-09-11

    申请人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61P9/12

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/14

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.

    摘要翻译： 本发明提供了具有优异的DMAE保存稳定性和透皮吸收性的透皮贴片。 补片具有一体地层叠在支撑体的一个表面上的支撑体和石膏层，并且膏药层包括：DMAE; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有碳原子数为2的烷基的丙烯酸烷基酯的丙烯酸粘合剂 到20 和通过使具有碳原子数为10〜20的烷基的饱和脂肪酸和碳数为2〜20的烷基的饱和脂肪族一元醇脱水缩合而制备的脂肪酸酯，其中DMAE的溶解度为0.05〜 在25℃下相对于脂肪酸酯为5g。

    TRANSDERMAL PATCH
    2.
    发明申请
    TRANSDERMAL PATCH 审中-公开
    透明贴

    公开(公告)号：US20120171274A1

    公开(公告)日：2012-07-05

    申请号：US13351724

    申请日：2012-01-17

    申请人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Hiroko Udagawa ,  Toshikazu Komoda ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61P9/00 ,  A61K31/137

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/14

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.

    摘要翻译： 本发明提供了具有优异的DMAE保存稳定性和透皮吸收性的透皮贴片。 补片具有一体地层叠在支撑体的一个表面上的支撑体和石膏层，并且膏药层包括：DMAE; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有碳数为2的烷基的丙烯酸烷基酯的丙烯酸粘合剂 到20 和通过使具有碳原子数为10〜20的烷基的饱和脂肪酸和碳数为2〜20的烷基的饱和脂肪族一元醇脱水缩合而制备的脂肪酸酯，其中DMAE的溶解度为0.05〜 在25℃下相对于脂肪酸酯为5g。

    TRANSDERMAL PATCH
    3.
    发明申请
    TRANSDERMAL PATCH 审中-公开
    透明贴

    公开(公告)号：US20120114738A1

    公开(公告)日：2012-05-10

    申请号：US13351750

    申请日：2012-01-17

    申请人： Toshikazu KOMODA ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Toshikazu KOMODA ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61K31/136

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/10

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.

    摘要翻译： 本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。 贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％ 碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。

    Transdermal patch
    4.
    发明申请
    Transdermal patch 审中-公开
    透皮贴片

    公开(公告)号：US20090317452A1

    公开(公告)日：2009-12-24

    申请号：US12310845

    申请日：2007-09-11

    申请人： Toshikazu Komoda ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    发明人： Toshikazu Komoda ,  Hiroko Udagawa ,  Masaru Hamabe ,  Yukihiko Noda ,  Sakiko Shibata ,  Masashi Yamada ,  Akihiro Kawashima ,  Hiroto Suzuki

    IPC分类号： A61K9/70 ,  A61K31/136 ,  A61P9/02

    CPC分类号： A61K31/137 ,  A61K9/7061 ,  A61K47/10

    摘要： The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAE or its pharmacologically acceptable salt. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: 2-amino-1-(2′,5′-dimethoxyphenyl)ethanol or its pharmacologically acceptable salt; 40 to 98% by weight of acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and 1 to 30% by weight of saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 10 to 30.

    摘要翻译： 本发明提供了具有优异的DMAE或其药理学上可接受的盐的保存稳定性和透皮吸收性的透皮贴剂。 贴剂在支撑体的一个表面上具有一体层压的支撑体和石膏层，石膏层包括：2-氨基-1-（2'，5'-二甲氧基苯基）乙醇或其药理学上可接受的盐; 通过共聚含有30〜99重量％的具有碳数为6〜22的烷基的甲基丙烯酸烷基酯和1〜70重量％的具有烷基的丙烯酸烷基酯的单体共聚而成的丙烯酸粘合剂为40〜98重量％ 碳数为2〜20; 和1〜30重量％的具有碳原子数为10〜30的烷基的饱和脂肪族一元醇。

    Therapeutic Agent for Sensory Abnormality
    5.
    发明申请
    Therapeutic Agent for Sensory Abnormality 审中-公开
    感觉异常的治疗剂

    公开(公告)号：US20090069442A1

    公开(公告)日：2009-03-12

    申请号：US11814008

    申请日：2006-01-18

    申请人： Hirohito Shiomi ,  Yutaka Tamura ,  Bang Luu ,  Masashi Yamada ,  Keizou Koyama ,  Hiroto Suzuki

    发明人： Hirohito Shiomi ,  Yutaka Tamura ,  Bang Luu ,  Masashi Yamada ,  Keizou Koyama ,  Hiroto Suzuki

    IPC分类号： A61K31/122 ,  C07C49/743 ,  A61P27/00

    CPC分类号： A61K31/122

    摘要： The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group].The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.

    摘要翻译： 本发明提供由下式（1）表示的感觉障碍治疗剂：其中R1，R2和R3各自表示氢原子或甲基，X表示直链或支链C 10 -C 28亚烷基或亚烯基 ]。 本发明的环己烯酮长链醇可以改善痛觉过敏或减轻痛觉过敏，因此可用作感觉障碍的治疗剂。 可以通过本发明预防或治疗的感觉障碍包括慢性顽固性疼痛，神经性疼痛，由神经损伤引起的疼痛阈值的降低，由糖尿病和神经损伤引起的感觉过敏或感觉异常等。

    Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect
    6.
    发明授权
    Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect 失效
    倍半萜类衍生物具有脂肪细胞分化抑制作用

    公开(公告)号：US07387800B2

    公开(公告)日：2008-06-17

    申请号：US10485801

    申请日：2002-08-09

    申请人： Munekazu Iinuma ,  Toshiyuki Tanaka ,  Makoto Ubukata ,  Nobuyasu Matsuura ,  Masashi Yamada ,  Hiroto Suzuki

    发明人： Munekazu Iinuma ,  Toshiyuki Tanaka ,  Makoto Ubukata ,  Nobuyasu Matsuura ,  Masashi Yamada ,  Hiroto Suzuki

    IPC分类号： A61K36/00

    CPC分类号： C07D307/93 ,  A23L33/105 ,  A61K31/335 ,  A61K36/28 ,  C07D493/04

    摘要： The objective of the present invention is to identify compounds having an inhibitory effect on adipocyte differentiation, and to provide pharmaceutical compositions and food compositions for prevention, improvement, or treatment of obesity or obesity related diseases. By enthusiastically studying natural products that inhibit the differentiation induction of adipocyte precursors into adipocytes, sesquiterpenoid derivatives, which are extracts from a Compositae plant, Calea, growing in Central and South America, were demonstrated to have an excellent inhibitory effect on adipocyte differentiation induction. Calea extract or the sesquiterpenoid derivatives are expected to be used in pharmaceutical compositions and food compositions for prevention, improvement, or treatment of obesity related diseases.

    摘要翻译： 本发明的目的是鉴定对脂肪细胞分化具有抑制作用的化合物，并提供用于预防，改善或治疗肥胖或肥胖相关疾病的药物组合物和食物组合物。 通过积极研究抑制脂肪细胞前体分化成脂肪细胞的天然产物，证明了在中美洲和南美洲生长的菊科植物提取物的倍半萜衍生物对脂肪细胞分化诱导具有优异的抑制作用。 预期Calea提取物或倍半萜衍生物可用于预防，改善或治疗肥胖相关疾病的药物组合物和食品组合物中。

    Indole derivatives substituted with long-chain alcolhols and medicaments containing them
    7.
    发明申请
    Indole derivatives substituted with long-chain alcolhols and medicaments containing them 失效
    用长链醇盐取代的吲哚衍生物和含有它们的药物

    公开(公告)号：US20050131053A1

    公开(公告)日：2005-06-16

    申请号：US10504484

    申请日：2002-02-13

    申请人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： C07D209/12 ,  A61K31/405 ,  C07D209/04

    CPC分类号： C07D209/12

    摘要： The invention relates to a flange coupling of two pipes, in particular the pipes of an exhaust system of a motor vehicle internal combustion engine. The coupling is characterized in that: each of the flanges is formed onto the corresponding pipe by the shaping of one of the pipe regions that form the respective flanges; a first of the two flanges is configured with a first connection pipe section, which engages radially in the interior of the second flange; a sealing ring is clamped between the flanges; the flanges are axially fixed by a clamping deice. The coupling is designed to be produced in an efficient manner, easy to mount and configured so that it functions reliably.

    摘要翻译： 本发明涉及两个管道，特别是机动车辆内燃机的排气系统的管道的法兰联接。 联轴器的特征在于：每个凸缘通过形成相应凸缘的一个管区形成在相应的管上; 两个凸缘中的第一个被构造成具有径向接合在第二凸缘内部的第一连接管段; 密封环夹在凸缘之间; 凸缘由夹紧芯轴向固定。 联轴器设计成能够以有效的方式生产，易于安装和配置，使其可靠运行。

    Indole derivatives substituted with long-chain alcohols and medicaments containing them
    8.
    发明授权
    Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
    被长链醇取代的吲哚衍生物和含有它们的药物

    公开(公告)号：US07902249B2

    公开(公告)日：2011-03-08

    申请号：US12132345

    申请日：2008-06-03

    申请人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： A61K31/404 ,  C07D209/04

    CPC分类号： C07D209/12

    摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

    摘要翻译： 提供由下式（I）表示的吲哚长链醇或其水合物或异构体：其中R1，R2，R3和R4各自独立地表示氢原子，甲基，乙酰基或 羟基，n表示0〜20的数; 以及含有该组合物的药物组合物。 吲哚长链醇（I）表现出优异的神经生长促进作用，以及有效的抗氧化和抗肿瘤作用，因此可用作脑疾病包括痴呆症和恶性肿瘤的预防和/或治疗剂 包括脑肿瘤。