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公开(公告)号：US08278270B2
公开(公告)日：2012-10-02
申请号：US13175110
申请日：2011-07-01
CPC分类号： C07K14/4753 , A61K38/00
摘要： An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
摘要翻译： 一种HGF前体蛋白质变体，其中肽结构包含插入在H链α链或多肽之间的肽链X的序列，其中缺失来自α链C末端的1-20个氨基酸残基， 一个 的HGF链或多肽，其中从＆lt; bgr的N末端1至20个氨基酸残基; 链被删除; 其中（i）肽链X具有至少两个残基的氨基酸序列，（ii）肽链X可以通过蛋白酶反应或化学反应来切割，和（iii）通过至少裂解获得的蛋白质 肽链X的一个位点具有HGF作用。
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公开(公告)号：US20110269944A1
公开(公告)日：2011-11-03
申请号：US13175110
申请日：2011-07-01
IPC分类号： C07K14/475
CPC分类号： C07K14/4753 , A61K38/00
摘要： An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
摘要翻译： 一种HGF前体蛋白质变体，其中肽结构包含插入在H链α链或多肽之间的肽链X的序列，其中缺失来自α链C末端的1-20个氨基酸残基， 一个 的HGF链或多肽，其中从＆lt; bgr的N末端1至20个氨基酸残基; 链被删除; 其中（i）肽链X具有至少两个残基的氨基酸序列，（ii）肽链X可以通过蛋白酶反应或化学反应来切割，和（iii）通过至少裂解获得的蛋白质 肽链X的一个位点具有HGF作用。
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公开(公告)号：US20060293275A1
公开(公告)日：2006-12-28
申请号：US10565301
申请日：2005-03-28
IPC分类号： A61K31/727
CPC分类号： C08B37/0075 , A61K31/7016 , A61K31/702 , A61K31/715 , C07H11/00 , C08B37/0078 , C08L5/10 , C12P19/04
摘要： The present invention aims to provide an agent for promoting HGF production comprising, as an effective ingredient, a disaccharide comprised of an uronic acid residue (wherein an uronic acid means an iduronic acid or a glucuronic acid, and has the same meaning hereinafter) and a glucosamine residue that are connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, or an oligosaccharide of tri- to hexadeca-saccharides having a structure in which uronic acid residues and glucosamine residues are alternately and repeatedly connected by α1,4-glycosidic linkage or β1,4-glycosidic linkage, wherein at least one hydroxy group of the uronic acid residues and/or the glucosamine residues may be sulfated, alkylated, acylated or aminated, and/or the amino group at position 2 of at least one of the glucosamine residue(s) may be sulfated, alkylated or acylated, or a salt thereof. The agent of the present invention for promoting HGF production is useful to promote healing of damaged tissues or organs of a living body.
摘要翻译： 本发明的目的在于提供一种促进HGF生产的试剂，其包含由糖醛酸残基（其中糖醛酸表示艾杜糖醛酸或葡糖醛酸，并且具有下述相同含义）的二糖作为有效成分，和 通过α1,4-糖苷键或β1,4-糖苷键连接的葡糖胺残基或具有其中糖醛酸残基和葡糖胺残基被α1,44交替并重复连接的结构的三十六碳糖的寡糖 - 糖苷键或β1,4-糖苷键，其中所述糖醛酸残基和/或所述葡糖胺残基的至少一个羟基可以被硫酸化，烷基化，酰化或胺化，和/或至少在第2位的氨基 一种或多种葡糖胺残基可被硫酸化，烷基化或酰化，或其盐。 用于促进HGF产生的本发明的药剂可用于促进活体损伤的组织或器官的愈合。
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公开(公告)号：US20050221441A1
公开(公告)日：2005-10-06
申请号：US11041363
申请日：2005-01-25
IPC分类号： A61K38/00 , C07K14/475 , C07H21/04 , C12N15/09
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译： 本发明提供具有引入氨基酸序列的突变的糖基化缺陷型HGF片段，以防止肝细胞生长因子（HGF）的至少一个糖基化位点的糖基化及其制备方法。 本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。
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公开(公告)号：US08003607B2
公开(公告)日：2011-08-23
申请号：US12226448
申请日：2007-03-30
CPC分类号： C07K14/4753 , A61K38/00
摘要： An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
摘要翻译： 一种HGF前体蛋白质变体，其中肽结构包含插入在H链α链或多肽之间的肽链X的序列，其中缺失来自α链C末端的1-20个氨基酸残基， 一个 的HGF链或多肽，其中从＆lt; bgr的N末端1至20个氨基酸残基; 链被删除; 其中（i）肽链X具有至少两个残基的氨基酸序列，（ii）肽链X可以通过蛋白酶反应或化学反应来切割，和（iii）通过至少裂解获得的蛋白质 肽链X的一个位点具有HGF作用。
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公开(公告)号：US20090209463A1
公开(公告)日：2009-08-20
申请号：US12226448
申请日：2007-03-30
IPC分类号： A61K38/18 , C07K14/475 , C12P21/06
CPC分类号： C07K14/4753 , A61K38/00
摘要： An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.
摘要翻译： 一种HGF前体蛋白质变体，其中肽结构包含插入在HGF的α链或多肽之间的肽链X的序列，其中缺失来自α链的C末端的1至20个氨基酸残基，以及 HGF的β链或多肽，其中β链的N末端有1至20个氨基酸残基被缺失; 其中（i）肽链X具有至少两个残基的氨基酸序列，（ii）肽链X可以通过蛋白酶反应或化学反应来切割，和（iii）通过至少裂解获得的蛋白质 肽链X的一个位点具有HGF作用。
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公开(公告)号：US20070161549A1
公开(公告)日：2007-07-12
申请号：US10582973
申请日：2004-12-15
IPC分类号： A61K38/18 , A61K48/00 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译： 本发明提供了修饰的糖基化缺陷型HGF及其制备方法。 通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。
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公开(公告)号：US20050164918A1
公开(公告)日：2005-07-28
申请号：US10926088
申请日：2004-08-26
IPC分类号： A61K38/00 , C07K14/475 , A61K38/18
CPC分类号： C07K14/4753
摘要： The present invention provides a segment of glycosylation-deficient HGF having mutation(s) introduced into an amino acid sequence so as to prevent glycosylation at at least one glycosylation site of a hepatocyte growth factor (HGF), and a method of producing the same. The segment of glycosylation-deficient HGF of the present invention has the same activity as that of a segment of glycosylated HGF, therefore, it is useful as an alternate for a segment of glycosylated HGF.
摘要翻译： 本发明提供了具有引入氨基酸序列的突变以防止肝细胞生长因子（HGF）的至少一个糖基化位点处的糖基化的糖基化缺陷型HGF的片段及其制备方法。 本发明的糖基化缺陷型HGF片段具有与糖基化HGF片段相同的活性，因此，作为糖基化HGF片段的替代物是有用的。
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公开(公告)号：US20100222274A1
公开(公告)日：2010-09-02
申请号：US12722823
申请日：2010-03-12
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译： 本发明提供了修饰的糖基化缺陷型HGF及其制备方法。 通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。
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公开(公告)号：US08420350B2
公开(公告)日：2013-04-16
申请号：US12722823
申请日：2010-03-12
CPC分类号： C07K14/4753 , A61K48/00
摘要： The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
摘要翻译： 本发明提供了修饰的糖基化缺陷型HGF及其制备方法。 通过引入氨基酸突变来产生糖基化缺陷型HGF，使得在肝细胞生长因子的至少一个糖基化位点处不发生糖基化。
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