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公开(公告)号：US07035738B2
公开(公告)日：2006-04-25
申请号：US10141099
申请日：2002-05-07
CPC分类号： G06F19/20 , C12Q1/6811 , G06F19/22
摘要： Where a DNA chip corresponding to a bacterium that is a subsequently added identification object is produced, temporal and pecuniary cost is reduced, and even where a probe unique to the DNA sequence of an identification object cannot be designed, precision in identifying DNA comprised in a sample is maximized. First, on designing a probe, a plurality of different probes are prepared to one kind of bacterium. Where some probes come to be not available by addition of bacteria that are new identification objects, identification is carried out using the remaining probes. Where a probe unique to an identification target bacterium cannot be designed, a probability of correct identification is increased by using multiple probes. Moreover, in consideration with a possibility that multiple kinds of bacteria simultaneously exist, a combination of probes that maximizes a probability of correct identification is selected.
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公开(公告)号：US20110106846A1
公开(公告)日：2011-05-05
申请号：US13000393
申请日：2009-06-25
IPC分类号： G06F17/30
CPC分类号： G06F17/30115
摘要： Provided is a file (document) management process for efficiently understanding a summary of files in a folder without checking the contents of the individual subfolders or files. A summary of a plurality of files included in a folder is generated dynamically (each time the folder is accessed by placing a cursor on the folder, for example) and is displayed. For example, a summary of a feature of files included in a folder, which is recognized as being different from the feature of a plurality of files included in a sibling folder through comparison, determined on the basis of a feature or tendency of a file attribute, is described, and a location distribution of query-hit documents in the tiered folder is displayed.
摘要翻译： 提供了一种用于在不检查各个子文件夹或文件的内容的情况下有效地理解文件夹中的文件的摘要的文件（文档）管理过程。 动态地生成包含在文件夹中的多个文件的摘要（每次通过将光标放置在文件夹上进行访问时），并显示。 例如，基于文件属性的特征或倾向来确定包含在文件夹中的文件的特征的摘要，其被识别为不同于通过比较的兄弟文件夹中包括的多个文件的特征 ，并且显示分层文件夹中的查询命中文档的位置分布。
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公开(公告)号：US20110179072A1
公开(公告)日：2011-07-21
申请号：US13120480
申请日：2009-11-27
IPC分类号： G06F17/30
CPC分类号： G06Q10/10
摘要： To create and manage vouchers by fully checking the contents of the vouchers so that the vouchers will not contain any flaws in description. Information described in a voucher is analyzed through the analysis of the logical structure of the voucher. It is checked, based on RCM (risk control matrix) prepared for internal control purposes, if an item described in the voucher satisfies a predetermined relationship and also if items described in vouchers, which are generated through a series of operations, satisfy a predetermined relationship. Then, a warning is displayed and entry of modification is accepted.
摘要翻译： 通过充分检查凭证的内容来创建和管理凭单，以便凭证不会包含任何描述的缺陷。 通过分析凭证的逻辑结构来分析凭证中描述的信息。 根据为内部控制目的准备的RCM（风险控制矩阵），如果凭证中描述的项满足预定关系，并且还通过一系列操作产生的凭证中描述的项满足预定关系， 。 然后，显示警告并接受修改的输入。
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公开(公告)号：US20070202526A1
公开(公告)日：2007-08-30
申请号：US11705055
申请日：2007-02-12
申请人： Yu Nakami , Ryo Nakashige , Yasuyuki Nozaki , Toshiko Matsumoto
发明人： Yu Nakami , Ryo Nakashige , Yasuyuki Nozaki , Toshiko Matsumoto
CPC分类号： G06F19/18 , C12Q2600/156
摘要： A method and a system for evaluating results of differentiating genotype signals and noise signals when a DNA fragment containing a gene to be analyzed is amplified by PCR and detected by electrophoresis are provided. An outlier of genotyping results is detected based on the fact that, when using the same marker, the height ratio of a stutter peak to a true peak and the height ratio of a +A peak to a true peak are reproducible, and that a constant size value is obtained with the use of the same allele of the same marker. In addition, a waveform obtained in past processes with the use of the same marker or the same allele is obtained utilizing a database by focusing on reproducibility. Also, a database is extended so as to obtain improved evaluation ability in a manner such that appropriate waveform data from which an outlier is not obtained is additionally registered in a database.
摘要翻译： 提供了当通过PCR扩增含有待分析基因的DNA片段并通过电泳检测时，鉴别鉴别基因型信号和噪声信号的结果的方法和系统。 基于以下事实来检测基因分型结果的异常值：当使用相同的标记时，口吃峰与真实峰的高度比和+ A峰与真实峰的高度比是可重现的，并且恒定 使用相同标记的相同等位基因获得大小值。 此外，通过关注再现性，利用数据库获得使用相同标记或相同等位基因的过去方法获得的波形。 此外，扩展数据库以便以使得没有获得异常值的适当波形数据另外登记在数据库中的方式获得改进的评估能力。
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公开(公告)号：US20080320388A1
公开(公告)日：2008-12-25
申请号：US12153997
申请日：2008-05-28
IPC分类号： G06F17/00
CPC分类号： G16B45/00 , C12Q2600/156 , G16B30/00
摘要： Apparatus and method for appropriately processing gene information in order to allow an easy estimation of haplotypes in large quantities of genome data. A list of genotypes at a plurality of gene loci in a plurality of individuals is displayed, using individual data and gene locus data. The individual data indicates gene loci of individuals and the genotype that exists at each gene locus. The gene locus data indicates a major allele and a minor allele at each gene locus. The individual genotypes are color-coded when they are displayed depending on whether they consist of homozygous major alleles, homozygous minor alleles, or heterozygous major and minor alleles at a particular gene locus.
摘要翻译： 用于适当处理基因信息的装置和方法，以便容易地估计大量基因组数据中的单倍型。 使用个体数据和基因位点数据显示多个个体中多个基因座的基因型列表。 个体数据表示个体的基因座和存在于各基因座的基因型。 基因位点数据表示每个基因座处的主要等位基因和次要等位基因。 根据它们是否由纯合的主要等位基因，纯合的次要等位基因或特定基因座处的杂合的主要和次要等位基因组成，单个基因型是显色的。
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公开(公告)号：US20050181412A1
公开(公告)日：2005-08-18
申请号：US11057223
申请日：2005-02-15
CPC分类号： G16B45/00 , C12Q2600/156 , G16B30/00
摘要： Apparatus and method for appropriately processing gene information in order to allow an easy estimation of haplotypes in large quantities of genome data. A list of genotypes at a plurality of gene loci in a plurality of individuals is displayed, using individual data and gene locus data. The individual data indicates gene loci of individuals and the genotype that exists at each gene locus. The gene locus data indicates a major allele and a minor allele at each gene locus. The individual genotypes are color-coded when they are displayed depending on whether they consist of homozygous major alleles, homozygous minor alleles, or heterozygous major and minor alleles at a particular gene locus.
摘要翻译： 用于适当处理基因信息的装置和方法，以便容易地估计大量基因组数据中的单倍型。 使用个体数据和基因位点数据显示多个个体中多个基因座的基因型列表。 个体数据表示个体的基因座和存在于各基因座的基因型。 基因位点数据表示每个基因座处的主要等位基因和次要等位基因。 根据它们是否由纯合的主要等位基因，纯合的次要等位基因或特定基因座处的杂合的主要和次要等位基因组成，单个基因型是显色的。
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公开(公告)号：US08661064B2
公开(公告)日：2014-02-25
申请号：US13000393
申请日：2009-06-25
CPC分类号： G06F17/30115
摘要： Provided is a file (document) management process for efficiently understanding a summary of files in a folder without checking the contents of the individual subfolders or files. A summary of a plurality of files included in a folder is generated dynamically (each time the folder is accessed by placing a cursor on the folder, for example) and is displayed. For example, a summary of a feature of files included in a folder, which is recognized as being different from the feature of a plurality of files included in a sibling folder through comparison, determined on the basis of a feature or tendency of a file attribute, is described, and a location distribution of query-hit documents in the tiered folder is displayed.
摘要翻译： 提供了一种用于在不检查各个子文件夹或文件的内容的情况下有效地理解文件夹中的文件的摘要的文件（文档）管理过程。 动态地生成包含在文件夹中的多个文件的摘要（每次通过将光标放置在文件夹上进行访问时），并显示。 例如，基于文件属性的特征或倾向来确定包含在文件夹中的文件的特征的摘要，其被识别为不同于通过比较的兄弟文件夹中包括的多个文件的特征 ，并且显示分层文件夹中的查询命中文档的位置分布。
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公开(公告)号：US07783430B2
公开(公告)日：2010-08-24
申请号：US11705055
申请日：2007-02-12
申请人： Yu Nakami , Ryo Nakashige , Yasuyuki Nozaki , Toshiko Matsumoto
发明人： Yu Nakami , Ryo Nakashige , Yasuyuki Nozaki , Toshiko Matsumoto
IPC分类号： G06F7/00
CPC分类号： G06F19/18 , C12Q2600/156
摘要： A method and a system for evaluating results of differentiating genotype signals and noise signals when a DNA fragment containing a gene to be analyzed is amplified by PCR and detected by electrophoresis are provided.An outlier of genotyping results is detected based on the fact that, when using the same marker, the height ratio of a stutter peak to a true peak and the height ratio of a +A peak to a true peak are reproducible, and that a constant size value is obtained with the use of the same allele of the same marker. In addition, a waveform obtained in past processes with the use of the same marker or the same allele is obtained utilizing a database by focusing on reproducibility. Also, a database is extended so as to obtain improved evaluation ability in a manner such that appropriate waveform data from which an outlier is not obtained is additionally registered in a database.
摘要翻译： 提供了当通过PCR扩增含有待分析基因的DNA片段并通过电泳检测时，鉴别鉴别基因型信号和噪声信号的结果的方法和系统。 基于以下事实来检测基因分型结果的异常值：当使用相同的标记时，口吃峰与真实峰的高度比和+ A峰与真实峰的高度比是可重现的，并且恒定 使用相同标记的相同等位基因获得大小值。 此外，通过关注再现性，利用数据库获得使用相同标记或相同等位基因的过去方法获得的波形。 此外，扩展数据库以便以使得没有获得异常值的适当波形数据另外登记在数据库中的方式获得改进的评估能力。
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公开(公告)号：US20070134706A1
公开(公告)日：2007-06-14
申请号：US11635560
申请日：2006-12-08
摘要： A gene information display method and apparatus for displaying waveform data obtained by fluorescence analysis of a DNA fragment that is subjected to PCR amplification and electrophoresis, in such a manner as to allow an experimental error to be easily detected through visual inspection. The apparatus, which displays the result of analysis of the length of a DNA fragment based on a detection signal from a PCR amplification product thereof, includes a processing unit for displaying detection signals from the PCR amplification products of a plurality of individuals in a graph in an overlapped manner. In the graph, the intensity of the detection signal is shown on a first axis and the fragment length is shown on a second axis.
摘要翻译： 一种用于显示通过荧光分析获得的经PCR扩增和电泳的DNA片段获得的波形数据的基因信息显示方法和装置，以允许通过目视检查容易地检测到实验误差。 基于来自其PCR扩增产物的检测信号显示DNA片段的长度分析结果的装置包括处理单元，用于显示图中多个个体的PCR扩增产物的检测信号 重叠的方式。 在该曲线图中，检测信号的强度显示在第一轴上，并且片段长度显示在第二轴上。
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10.发明申请Gene information processing apparatus and gene information display apparatus 审中-公开基因信息处理装置和基因信息显示装置公开(公告)号：US20090182512A1
公开(公告)日：2009-07-16
申请号：US12010599
申请日：2008-01-28
申请人： Toshiko Matsumoto , Ryo Nakashige
发明人： Toshiko Matsumoto , Ryo Nakashige
摘要： For automatic genotype determination based on microsatellites, when a +A peak occurrence pattern largely varies due to excessively intense fluorescent signal, incapability of separating peaks completely, and incomplete experimental conditions, a decreased precision in noise removal and time requirement for visual check and correction become bottlenecks in the analysis. On the basis of data about alleles which have been reported to be observed in a marker, it is investigated whether or not a sample is suitable to be used for examining a +A peak occurrence pattern, which peak can be a starting point for examining the +A peak occurrence pattern, and whether the reported allele is a true peak or the +A peak thereof. According to the obtained data, the +A peak occurrence pattern is estimated. In this process, it is possible to perform an accurate estimation, and therefore, a precision for noise removal in automatic genotype discrimination can be improved.
摘要翻译： 对于基于微卫星的自动基因型测定，当a + A峰发生模式由于过度强烈的荧光信号而极大地变化时，完全不能完全分离峰，并且不完全的实验条件，降低的噪声去除精度和视觉检查和校正的时间要求变得 分析瓶颈。 根据已经报道在标记中观察到的等位基因的数据，调查样品是否适合用于检查+ A峰发生模式，该峰可以作为检查的起始点 +峰值出现模式，以及报告的等位基因是否为真峰值或其+ A峰。 根据获得的数据，估计+ A峰值出现模式。 在该过程中，可以进行准确的估计，因此可以提高自动基因型鉴别中的噪声消除的精度。
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