-
公开(公告)号：US08163892B2
公开(公告)日：2012-04-24
申请号：US12839264
申请日：2010-07-19
CPC分类号： A61K48/0058 , A61K9/0019 , A61K35/761 , A61K38/162 , C12N7/00 , C12N9/1241 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , A61K2300/00
摘要： By using a virus having a gene sequence comprising a telomerase promoter and an E1 gene (preferably a sequence comprising E1A gene, IRES sequence and E1B gene) or by using an anticancer agent comprising the virus, the virus replicates in cancer cells to thereby produce an efficient anticancer effect.
摘要翻译： 通过使用具有包含端粒酶启动子和E1基因（优选为E1A基因，IRES序列和E1B基因的序列）的基因序列的病毒，或者通过使用包含该病毒的抗癌剂，将该病毒复制在癌细胞中， 有效的抗癌作用。
-
公开(公告)号：US20060239967A1
公开(公告)日：2006-10-26
申请号：US10520901
申请日：2003-07-07
IPC分类号： A61K48/00 , C12N15/861 , C12N7/00
CPC分类号： A61K48/0058 , C12N9/1241
摘要： By using a virus having a gene sequence comprising a telomerase promoter and an E1 gene (preferably a sequence comprising E1A gene, IRES sequence and E1B gene) or by using an anticancer agent comprising the virus, the virus replicates in cancer cells to thereby produce an efficient anticancer effect.
摘要翻译： 通过使用具有包含端粒酶启动子和E1基因（优选为E1A基因，IRES序列和E1B基因的序列）的基因序列的病毒，或者通过使用包含该病毒的抗癌剂，将该病毒复制在癌细胞中， 有效的抗癌作用。
-
公开(公告)号：US20080032283A1
公开(公告)日：2008-02-07
申请号：US11696965
申请日：2007-04-05
CPC分类号： C12N15/86 , A61K49/0047 , C07K14/4702 , C07K14/70575 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12N2840/203 , G01N33/574
摘要： The present invention relates to providing a reagent for cancer cell detection or cancer diagnosis, a pharmaceutical composition for the treatment of cancer, and a method of treating or preventing cancer in a subject. Specifically, the present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a replication cassette comprising a promoter from human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order is integrated in E1 region of the viral genome and a labeling cassette comprising a gene encoding a labeling protein and a promoter capable of regulating the expression of the gene encoding the labeling protein is integrated in E3 region of the viral genome.
摘要翻译： 本发明涉及提供用于癌细胞检测或癌症诊断的试剂，用于治疗癌症的药物组合物，以及治疗或预防受试者的癌症的方法。 具体地，本发明涉及一种癌细胞检测用试剂，其包含重组病毒，其中包含来自人端粒酶的启动子，E1A基因，IRES序列和E1B基因的复制盒依次整合在 病毒基因组和包含编码标记蛋白的基因和能够调节编码标记蛋白的基因的表达的启动子的标记盒整合在病毒基因组的E3区中。
-
公开(公告)号：US20060067890A1
公开(公告)日：2006-03-30
申请号：US11158479
申请日：2005-06-21
IPC分类号： A61K49/00 , A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K49/0047 , C07K14/4702 , C07K14/70575 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12N2840/203 , G01N33/574
摘要： The present invention provides a reagent for cancer cell detection or cancer diagnosis. The present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a replication cassette comprising a promoter from human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order is integrated in E1 region of the viral genome and a labeling cassette comprising a gene encoding a labeling protein and a promoter capable of regulating the expression of the gene encoding the labeling protein is integrated in E3 region of the viral genome.
摘要翻译： 本发明提供了用于癌细胞检测或癌症诊断的试剂。 本发明涉及用于癌细胞检测的试剂，其包含重组病毒，其中包含来自人端粒酶的启动子，E1A基因，IRES序列和E1B基因的复制盒依次整合在病毒基因组的E1区 并且包含编码标记蛋白的基因和能够调节编码标记蛋白的基因的表达的启动子的标记盒整合在病毒基因组的E3区域中。
-
公开(公告)号：US20100150884A1
公开(公告)日：2010-06-17
申请号：US11884221
申请日：2006-02-10
申请人： Toshiyoshi Fujiwara , Noriaki Tanaka , Satoru Kyo
发明人： Toshiyoshi Fujiwara , Noriaki Tanaka , Satoru Kyo
CPC分类号： A61K31/475 , A61K31/337 , A61K31/4745 , A61K35/761 , A61K38/1758 , A61K45/06 , A61K48/00 , A61K2300/00
摘要： The present invention relates to providing a pharmaceutical composition with a still more enhanced anticancer activity. Specifically, the present invention relates to a pharmaceutical composition for combination therapy for tumors, comprising a recombinant virus comprising a polynucleotide containing a promoter for human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order, and a substance having an antitumor effect.
摘要翻译： 本发明涉及提供具有更强的抗癌活性的药物组合物。 具体地说，本发明涉及用于肿瘤的组合疗法的药物组合物，其含有包含依次包含人端粒酶启动子，E1A基因，IRES序列和E1B基因的多核苷酸的重组病毒，以及具有 抗肿瘤作用。
-
公开(公告)号：US07943373B2
公开(公告)日：2011-05-17
申请号：US11158479
申请日：2005-06-21
CPC分类号： C12N15/86 , A61K49/0047 , C07K14/4702 , C07K14/70575 , C12N7/00 , C12N2710/10343 , C12N2830/008 , C12N2840/203 , G01N33/574
摘要： The present invention provides a reagent for cancer cell detection or cancer diagnosis. The present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a replication cassette comprising a promoter from human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order is integrated in E1 region of the viral genome and a labeling cassette comprising a gene encoding a labeling protein and a promoter capable of regulating the expression of the gene encoding the labeling protein is integrated in E3 region of the viral genome.
摘要翻译： 本发明提供了用于癌细胞检测或癌症诊断的试剂。 本发明涉及用于癌细胞检测的试剂，其包含重组病毒，其中包含来自人端粒酶的启动子，E1A基因，IRES序列和E1B基因的复制盒依次整合在病毒基因组的E1区 并且包含编码标记蛋白的基因和能够调节编码标记蛋白的基因的表达的启动子的标记盒整合在病毒基因组的E3区域中。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.021 秒)