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1.发明申请Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权二肽基肽酶IV抑制剂的生产方法和化合物及其中间体公开(公告)号：US20050090539A1
公开(公告)日：2005-04-28
申请号：US10716012
申请日：2003-11-18
申请人： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
发明人： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
IPC分类号： A61K31/403 , A61K31/435 , C07C62/06 , C07C69/00 , C07C69/716 , C07C229/28 , C07C271/22 , C07D20060101 , C07D201/00 , C07D207/22 , C07D207/277 , C07D209/02 , C07D209/52 , C07D221/02
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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2.发明授权Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权二肽基肽酶IV抑制剂的生产方法和化合物及其中间体公开(公告)号：US08278462B2
公开(公告)日：2012-10-02
申请号：US12712958
申请日：2010-02-25
申请人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, Jr. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
发明人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, Jr. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
IPC分类号： C07D209/52
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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3.发明授权Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 失效二肽基肽酶IV抑制剂的生产方法和化合物及其中间体公开(公告)号：US07705033B2
公开(公告)日：2010-04-27
申请号：US12181216
申请日：2008-07-28
申请人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, Jr. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
发明人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, Jr. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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4.发明申请公开(公告)号：US20130012723A1
公开(公告)日：2013-01-10
申请号：US13601477
申请日：2012-08-31
申请人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, JR. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
发明人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, JR. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
IPC分类号： C07D209/52 , C12N1/21 , C12N1/19 , C07D207/22
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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5.发明申请METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF 失效用于生产二磷酸酯酶IV抑制剂的方法和化合物及其中间体公开(公告)号：US20090018311A1
公开(公告)日：2009-01-15
申请号：US12181216
申请日：2008-07-28
申请人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, JR. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
发明人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, JR. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
IPC分类号： C07K1/02 , C07D207/22 , C07D209/52 , C07C209/08 , C12N1/21 , C07C51/09
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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6.发明申请METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF 有权用于生产二磷酸酯酶IV抑制剂的方法和化合物及其中间体公开(公告)号：US20100274025A1
公开(公告)日：2010-10-28
申请号：US12712958
申请日：2010-02-25
申请人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, JR. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
发明人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, JR. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
IPC分类号： C07D209/52 , C07D207/22 , C07C57/28 , C12N1/19 , C12N1/21
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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7.发明授权Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权二肽基肽酶IV抑制剂的生产方法和化合物及其中间体公开(公告)号：US07420079B2
公开(公告)日：2008-09-02
申请号：US10716012
申请日：2003-11-18
申请人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, Jr. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
发明人： Truc Chi Vu , David B. Brzozowski , Rita Fox , Jollie Duaine Godfrey, Jr. , Ronald L. Hanson , Sergei V. Kolotuchin , John A. Mazzullo , Ramesh N. Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason J. Zhu , David R. Magnin , David J. Augeri , Lawrence G. Hamann
IPC分类号： C07C69/52 , C07C229/02
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译： 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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公开(公告)号：US07227019B2
公开(公告)日：2007-06-05
申请号：US10489625
申请日：2002-09-13
申请人： Jianji Wang
发明人： Jianji Wang
IPC分类号： C07H19/00 , C07H19/22 , C07G17/00 , C07D487/00
CPC分类号： C07H19/23 , C07D487/14
摘要： The present invention relates to a method for making an indolopyrrolocarbazole of the general formula [I], where the method includes the step of reacting a bisindolylmaleimide compound with an oxidizing agent in the presence of an oxygen containing gas at a temperature and for a time sufficient to yield the indolopyrrolocarbazole compound of the general formula [I]. Methods of making rebeccamycin analogs using the indolopyrrolocarbazole compound are also provided
摘要翻译： 本发明涉及制备通式[I]的吲哚并吡咯并咔唑的方法，其中该方法包括在含氧气体存在下，在足够的温度和时间下使双吲哚基马来酰亚胺化合物与氧化剂反应的步骤 得到通式[I]的吲哚并吡咯并咔唑化合物。 还提供了使用吲哚并吡咯咔唑化合物制备雷贝霉素类似物的方法
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