公开(公告)号：US08795175B2

公开(公告)日：2014-08-05

申请号：US12252809

申请日：2008-10-16

申请人： Tsukasa Funane ,  Naoki Tanaka ,  Hideaki Koizumi ,  Atsushi Maki

发明人： Tsukasa Funane ,  Naoki Tanaka ,  Hideaki Koizumi ,  Atsushi Maki

IPC分类号： A61B5/00 ,  A61B5/02

CPC分类号： A61B5/14553 ,  A61B5/02416

摘要： Cerebral blood volume changes are measured to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its change over time to thereby estimate and display diseased and dangerous portions based on the evaluation. This is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.

摘要翻译： 测量脑血容量变化，从这些变化的低频成分的特性和通过分析计算出的心率变化的性质来评估脑血管硬度的分布及其随时间的变化，从而基于以下方式估计和显示患病和危险部分： 评估。 这是通过具有测量被检测体的局部脑血容量的脑血容量测量单元的生物测量系统，分析由脑血容量测量单元测量的信号的分析单元，提取单元， 基于分析单元的输出，关于测试体的区域性脑血管状态的信息和显示脑血容量测量单元的测量结果的显示单元，分析器单元的分析结果或提取结果 的提取单位。

公开(公告)号：US20090143654A1

公开(公告)日：2009-06-04

申请号：US12252809

申请日：2008-10-16

申请人： Tsukasa FUNANE ,  Naoki Tanaka ,  Hideaki Koizumi ,  Atsushi Maki

发明人： Tsukasa FUNANE ,  Naoki Tanaka ,  Hideaki Koizumi ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/02416

摘要： This invention measures cerebral blood volume changes to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its with-time change to thereby estimate and display diseased and dangerous portions based on the evaluation. Briefly, the above-noted object is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.

摘要翻译： 本发明通过分析计算出的这种变化和心率变化的低频成分的特性，脑血管硬度的分布及其随时间的变化来测量脑血容量变化，从而评估和显示患病危险部位 基于评估。 简而言之，上述目的可通过具有测量被测体的局部脑血容量的脑血容量测量单元的生物测量系统，分析由脑血容量测量单元测量的信号的分析器单元来实现， 提取单元，用于根据分析单元的输出提取关于测试体的区域性脑血管状态的信息;以及显示单元，显示脑血容量测量单元的测量结果，分析结果 分析器单元或提取单元的提取结果。

公开(公告)号：US20070287922A1

公开(公告)日：2007-12-13

申请号：US11696295

申请日：2007-04-04

申请人： Naoki Tanaka ,  Atsushi Maki ,  Takushige Katsura

发明人： Naoki Tanaka ,  Atsushi Maki ,  Takushige Katsura

IPC分类号： A61B5/02

CPC分类号： A61B5/0261 ,  A61B5/021 ,  A61B5/02416 ,  A61B5/6814

摘要： A living body measurement system including a cerebral blood volume measurement unit for measuring a regional cerebral blood volume of a subject, an arterial pressure/heart rate measurement unit for measuring an arterial pressure and/or a heart rate of the subject, an analysis unit for analyzing signals measured by the cerebral blood volume measurement unit and the arterial pressure/heart rate measurement unit, an extraction unit for extracting information concerning a regional cerebral vascular state of the subject on the basis of an output of the analysis unit, and a display unit for displaying a measurement result measured by the cerebral blood volume measurement unit and/or the arterial pressure/heart rate measurement unit, an analysis result analyzed by the analysis unit, or an extraction result extracted by the extraction unit.

摘要翻译： 一种生物体测量系统，包括用于测量对象的局部脑血容量的脑血容量测量单元，用于测量受试者的动脉压和/或心率的动脉压/心率测量单元，用于 分析由脑血容量测量单元和动脉压/心率测量单元测量的信号，提取单元，用于根据分析单元的输出提取关于对象的区域性脑血管状态的信息;以及显示单元 用于显示由脑血容量测量单元和/或动脉压/心率测量单元测量的测量结果，由分析单元分析的分析结果或由提取单元提取的提取结果。

公开(公告)号：US20080146901A1

公开(公告)日：2008-06-19

申请号：US11954627

申请日：2007-12-12

申请人： Takusige KATURA ,  Naoki Tanaka ,  Atsushi Maki

发明人： Takusige KATURA ,  Naoki Tanaka ,  Atsushi Maki

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/02028 ,  A61B5/6814 ,  A61B5/7207 ,  G06K9/6243

摘要： An optical measurement instrument for living body that comprises: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit comprises: a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.

摘要翻译： 一种生物体光学测量仪器，包括：多个光照射装置，用于用光照射待测物体; 多个光接收装置，用于检测照射到被测试物体上的光并在待测物体的内部传播; 以及计算单元，用于根据由光接收装置检测的检测信号计算被测物体内的多个因子的血液动力学，其中所述计算单元包括：分离计算单元，用于从所述检测信号中分离出多个信号; 选择单元，用于计算分离以选择其中相关系数为预定值或更大的信号的多个信号之间的相关系数作为噪声信号; 以及重建计算单元，用于重新配置除了由选择单元选择的噪声信号之外的检测信号。

公开(公告)号：US07285790B2

公开(公告)日：2007-10-23

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US20060100525A1

公开(公告)日：2006-05-11

申请号：US11205160

申请日：2005-08-17

申请人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

IPC分类号： A61B6/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/14553

摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

公开(公告)号：US07022083B2

公开(公告)日：2006-04-04

申请号：US10457478

申请日：2003-06-10

申请人： Naoki Tanaka ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Naoki Tanaka ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/486 ,  A61B5/0086 ,  A61B5/1455

摘要： A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.

摘要翻译： 在对给予生物体的刺激的响应的测量的测量中，可以仅获得少量的测量重复来获得满意的平均信号。 提取低频生物波动，并且与提取的波动的相位同步地向生物体提供刺激。

公开(公告)号：US08311600B2

公开(公告)日：2012-11-13

申请号：US11954627

申请日：2007-12-12

申请人： Takusige Katura ,  Naoki Tanaka ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Atsushi Maki

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/02028 ,  A61B5/6814 ,  A61B5/7207 ,  G06K9/6243

摘要： An optical measurement instrument for living body includes: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit includes a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.

摘要翻译： 一种用于生物体的光学测量仪器包括：多个光照射装置，用于用光照射被测物体; 多个光接收装置，用于检测照射到被测试物体上的光并在待测物体的内部传播; 以及计算单元，用于根据由光接收装置检测的检测信号计算被测物体内的多个因子的血液动力学，其中所述计算单元包括分离计算单元，用于从所述检测信号中分离出多个信号; 选择单元，用于计算分离以选择其中相关系数为预定值或更大的信号的多个信号之间的相关系数作为噪声信号; 以及重建计算单元，用于重新配置除了由选择单元选择的噪声信号之外的检测信号。

公开(公告)号：US20100256468A1

公开(公告)日：2010-10-07

申请号：US12600285

申请日：2008-02-01

申请人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B5/1455 ,  G06N5/02

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/14553

摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.

摘要翻译： 将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。 使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

公开(公告)号：US07565192B2

公开(公告)日：2009-07-21

申请号：US11205160

申请日：2005-08-17

申请人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/14553

摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

摘要翻译： 分配给测量大脑活动信号的典型任务持续10到30秒。 梅耶尔波噪声信号的频带非常接近脑活动信号的频带，结果是难以使用带通滤波器或带通滤波器来减少梅耶波噪声信号。 提供了用于检测已经通过或反射在组织内的发射光的光照射单元和光检测单元。 生物信号测量单元测量脉动，呼吸，血压和温度中的至少一个。 由光检测单元获得的光信号与使用非线性分析的生物信号之间的关系; 以及基于所获得的关系从生物噪声信号与光信号分离的计算。