公开(公告)号：US20100256468A1

公开(公告)日：2010-10-07

申请号：US12600285

申请日：2008-02-01

申请人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B5/1455 ,  G06N5/02

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/14553

摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.

摘要翻译： 将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。 使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

公开(公告)号：US07974671B2

公开(公告)日：2011-07-05

申请号：US10572357

申请日：2004-09-03

申请人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

发明人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/6822 ,  A61B5/742 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/046

摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.

摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

公开(公告)号：US20070055118A1

公开(公告)日：2007-03-08

申请号：US10571430

申请日：2004-09-09

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/14551 ,  A61B5/165

摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.

摘要翻译： 提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。 疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。 通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估疾病，并且通过在存储的特征量和特征量之间的相似性的多变量分析中应用多变量分析， 单位12.评估结果以条形图表示与各疾病组相似度的分数。

公开(公告)号：US07353054B2

公开(公告)日：2008-04-01

申请号：US10571430

申请日：2004-09-09

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/14551 ,  A61B5/165

摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.

摘要翻译： 提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。 疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。 通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估该疾病，并且通过应用提取的特征量和存储在存储器中的特征量的特征量之间的相似性的多变量分析来评估疾病 单位12.评估结果以条形图表示与各疾病组相似度的分数。

公开(公告)号：US20090118602A1

公开(公告)日：2009-05-07

申请号：US11916892

申请日：2006-06-08

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： A61B5/1455

CPC分类号： A61B5/145 ,  A61B5/14546 ,  A61B5/14553 ,  G06F19/00 ,  G16H50/70

摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.

摘要翻译： 提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分， 包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中 显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为 在散点图上进行评估，叠加在散点图上。 利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

公开(公告)号：US08386192B2

公开(公告)日：2013-02-26

申请号：US11916892

申请日：2006-06-08

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： G01N33/48

CPC分类号： A61B5/145 ,  A61B5/14546 ,  A61B5/14553 ,  G06F19/00 ,  G16H50/70

摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.

摘要翻译： 提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分， 包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中 显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为 在散点图上进行评估，叠加在散点图上。 利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

公开(公告)号：US07228166B1

公开(公告)日：2007-06-05

申请号：US10049313

申请日：2000-09-13

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B6/00

CPC分类号： A61B5/4094 ,  A61B5/0073 ,  A61B5/064 ,  A61B5/6814

摘要： A biological light measuring instrument for illuminating a subject with a plurality of beams of light from a plurality of illuminating positions, measuring the light beams transmitted through the subject, and creating a topographic image showing ecological information about the inside of the subject, comprising unit for creating three-dimensional coordinate data representing the relationship among the illuminating positions and a reference point on the subject and the relationship between the light measuring position and the reference point, unit for setting the illuminating positions and light measuring position on a three-dimensional shape image of the subject according to the three-dimensional coordinate data, and unit for creating a three-dimensional topographic image according to the three-dimensional coordinate data, and unit for superposing the three-dimensional topographic image on the shape image while maintaining the relationships of the illuminating positions and the light measuring position.

摘要翻译： 一种生物光测量仪器，用于利用来自多个照明位置的多个光束照射被检体，测量透过被检体的光束，以及创建显示关于被检体内部的生态信息的地形图像，其包括： 生成表示被检体的照明位置和基准点之间的关系的三维坐标数据以及光测量位置与基准点之间的关系，用于设置三维形状图像上的照明位置和光测量位置的单元 以及根据三维坐标数据创建三维地形图像的单元，以及用于将三维地形图像叠加在形状图像上的单元，同时保持三维坐标数据的关系 照明位置和灯m 确定位置

公开(公告)号：US20070142719A1

公开(公告)日：2007-06-21

申请号：US10578725

申请日：2004-11-01

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

IPC分类号： A61B5/00

CPC分类号： G06K9/0051 ,  A61B5/0261 ,  A61B5/4064 ,  A61B5/7203 ,  G06T5/002

摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.

摘要翻译： 对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。 从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。 显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。 因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

公开(公告)号：US08019399B2

公开(公告)日：2011-09-13

申请号：US10578725

申请日：2004-11-01

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

IPC分类号： A61B5/1455

CPC分类号： G06K9/0051 ,  A61B5/0261 ,  A61B5/4064 ,  A61B5/7203 ,  G06T5/002

摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.

摘要翻译： 对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。 从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。 显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。 因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

公开(公告)号：US08600720B2

公开(公告)日：2013-12-03

申请号：US12996190

申请日：2009-06-03

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Kiyoto Kasai ,  Ryu Takizawa ,  Yuki Kawakubo ,  Ayaka Takahashi ,  Hitoshi Kuwabara

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Kiyoto Kasai ,  Ryu Takizawa ,  Yuki Kawakubo ,  Ayaka Takahashi ,  Hitoshi Kuwabara

IPC分类号： G06G7/58

CPC分类号： A61B5/16 ,  A61B5/165

摘要： A load of a stimulating task on an examinee with a resting task being unstable is excluded, and an accurate answer of an examinee to presentation of a stimulating task is enabled. A stimulating task presentation device in a living body optical measurement device includes a stimulation presenting unit configured to present a stimulation to an examinee, a brain function measurement device for measuring a brain function of the examinee in parallel to presentation of the stimulation, and a stimulation presentation controller configured to control the stimulation presented by the stimulation presenting unit, and the stimulation presentation controller has a function of setting a resting task and a stimulating task to be presented to the examinee, a function of detecting an answer of the examinee to the resting task and the stimulating task, and a task presentation control function of determining the degree of stability on the basis of the detection result when the resting task is presented, and controlling presentation of the resting task or the stimulating task on the basis of the degree of stability.

摘要翻译： 在休息任务处于不稳定状态的受试者上的刺激任务的负担被排除在外，并且能够使受检者呈现刺激性任务的准确答案。 生物体光学测量装置中的刺激性任务呈现装置包括被配置为向受检者呈现刺激的刺激呈现单元，用于与呈现刺激并行地测量受检者的脑功能的脑功能测量装置，以及刺激 呈现控制器，被配置为控制由刺激呈现单元呈现的刺激，并且刺激呈现控制器具有将休息任务和刺激任务设置为被呈现给受检者的功能，检测受试者对休息的答案的功能 任务和刺激任务，以及当呈现休息任务时基于检测结果确定稳定程度的任务呈现控制功能，以及基于休息任务或刺激任务的程度来控制休息任务或刺激任务的呈现 稳定性。