公开(公告)号：US20100256468A1

公开(公告)日：2010-10-07

申请号：US12600285

申请日：2008-02-01

申请人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Naoki Tanaka ,  Masashi Kiguchi ,  Atsushi Maki ,  Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B5/1455 ,  G06N5/02

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/14553

摘要： The efficiency of separating normal control subjects from non-normal control subjects and separating disorders from one another is improved. Plural classification models having a stratified structure are used, and areas from which measurement data used in the plural classification models are acquired differ among the classification models.

摘要翻译： 将正常对照受试者与非正常对照受试者分离并将疾病彼此分离的效率提高。 使用具有分层结构的多个分类模型，并且获取在多个分类模型中使用的测量数据的区域在分类模型之间不同。

公开(公告)号：US07353054B2

公开(公告)日：2008-04-01

申请号：US10571430

申请日：2004-09-09

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/14551 ,  A61B5/165

摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.

摘要翻译： 提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。 疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。 通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估该疾病，并且通过应用提取的特征量和存储在存储器中的特征量的特征量之间的相似性的多变量分析来评估疾病 单位12.评估结果以条形图表示与各疾病组相似度的分数。

公开(公告)号：US20090118602A1

公开(公告)日：2009-05-07

申请号：US11916892

申请日：2006-06-08

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： A61B5/1455

CPC分类号： A61B5/145 ,  A61B5/14546 ,  A61B5/14553 ,  G06F19/00 ,  G16H50/70

摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.

摘要翻译： 提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分， 包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中 显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为 在散点图上进行评估，叠加在散点图上。 利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

公开(公告)号：US20070055118A1

公开(公告)日：2007-03-08

申请号：US10571430

申请日：2004-09-09

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Naoki Tanaka ,  Hideo Kawaguchi ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/14551 ,  A61B5/165

摘要： An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unit 15 for extracting features of the hemoglobin waveform, the feature analysis unit 16 and the storage unit 12 for storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unit 15 and by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unit 12. Results of assessment are shown as scores expressing similarity with each disease group in a bar graph.

摘要翻译： 提供了一种可以根据由光学测量装置测量的血红蛋白量变化的信号来客观地评估和显示受试者属于什么程度和哪种疾病所属的装置。 疾病评估装置包括用于提取血红蛋白波形的特征的特征提取单元15，特征分析单元16和用于将每种疾病的特征存储为数据库的存储单元12。 通过从特征提取单元15中的光学测量装置测量的对象的血红蛋白信号中提取各种特征量来评估疾病，并且通过在存储的特征量和特征量之间的相似性的多变量分析中应用多变量分析， 单位12.评估结果以条形图表示与各疾病组相似度的分数。

公开(公告)号：US08386192B2

公开(公告)日：2013-02-26

申请号：US11916892

申请日：2006-06-08

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Hideo Kawaguchi ,  Naoki Tanaka ,  Masahiko Mikuni ,  Masato Fukuda

IPC分类号： G01N33/48

CPC分类号： A61B5/145 ,  A61B5/14546 ,  A61B5/14553 ,  G06F19/00 ,  G16H50/70

摘要： There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.

摘要翻译： 提供了一种系统，用于支持被检查对象的哪一个疾病组属于被检者所在的整个疾病组中的哪一个或多个位置。该支持系统包括存储光学生物学特征值的数据存储部分， 包括多个疾病组中的患者的许多受试者的测量数据，从光学生物测量数据中提取多种特征值的分析部分和显示与字典数据相关联的分析部分中的分析结果的显示部分，其中 显示部分产生一个散点图，绘制了字典数据的特征值，其中两个特征值中的一个沿着横坐标轴绘制，另一个是沿着纵坐标轴绘制，并将主体的位置显示为 在散点图上进行评估，叠加在散点图上。 利用该散点图，可以一目了然地了解该受试者的特征与疾病组特征之间的关系。

公开(公告)号：US07228166B1

公开(公告)日：2007-06-05

申请号：US10049313

申请日：2000-09-13

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi

IPC分类号： A61B6/00

CPC分类号： A61B5/4094 ,  A61B5/0073 ,  A61B5/064 ,  A61B5/6814

摘要： A biological light measuring instrument for illuminating a subject with a plurality of beams of light from a plurality of illuminating positions, measuring the light beams transmitted through the subject, and creating a topographic image showing ecological information about the inside of the subject, comprising unit for creating three-dimensional coordinate data representing the relationship among the illuminating positions and a reference point on the subject and the relationship between the light measuring position and the reference point, unit for setting the illuminating positions and light measuring position on a three-dimensional shape image of the subject according to the three-dimensional coordinate data, and unit for creating a three-dimensional topographic image according to the three-dimensional coordinate data, and unit for superposing the three-dimensional topographic image on the shape image while maintaining the relationships of the illuminating positions and the light measuring position.

摘要翻译： 一种生物光测量仪器，用于利用来自多个照明位置的多个光束照射被检体，测量透过被检体的光束，以及创建显示关于被检体内部的生态信息的地形图像，其包括： 生成表示被检体的照明位置和基准点之间的关系的三维坐标数据以及光测量位置与基准点之间的关系，用于设置三维形状图像上的照明位置和光测量位置的单元 以及根据三维坐标数据创建三维地形图像的单元，以及用于将三维地形图像叠加在形状图像上的单元，同时保持三维坐标数据的关系 照明位置和灯m 确定位置

公开(公告)号：US20070142719A1

公开(公告)日：2007-06-21

申请号：US10578725

申请日：2004-11-01

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

IPC分类号： A61B5/00

CPC分类号： G06K9/0051 ,  A61B5/0261 ,  A61B5/4064 ,  A61B5/7203 ,  G06T5/002

摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.

摘要翻译： 对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。 从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。 显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。 因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

公开(公告)号：US08019399B2

公开(公告)日：2011-09-13

申请号：US10578725

申请日：2004-11-01

申请人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

发明人： Shingo Kawasaki ,  Noriyoshi Ichikawa ,  Naoki Tanaka

IPC分类号： A61B5/1455

CPC分类号： G06K9/0051 ,  A61B5/0261 ,  A61B5/4064 ,  A61B5/7203 ,  G06T5/002

摘要： A principal component analysis or an independent component analysis is conducted on the living body signals, e.g., local cerebral blood amount change signals obtained by the living body optical measurement to extract and display multiple component signals thereof. Signals other than the component signals containing noise are selected from these component signals automatically or manually, and the local cerebral blood amount change signals are reconstructed by using selected signals. The reconstructed signals is displayed and further subjected to the component analysis or the reconstruction as appropriate, and used for the profiling of information necessary for the diagnosis. Consequently, high-precision target signals can be obtained by completely removing external noise included in the living body signals, particularly the noise which cannot be adequately removed by the moving average and the filtering processings.

摘要翻译： 对生物体信号进行主成分分析或独立成分分析，例如通过生物体光学测定得到的局部脑血量变化信号，提取并显示多个成分信号。 从包含噪声的分量信号以外的信号自动地或手动地从这些分量信号中选择，并且通过使用所选择的信号重建局部脑血量变化信号。 显示重建的信号，并进一步进行成分分析或重建，并用于诊断所需信息的分析。 因此，通过完全去除包括在生物体信号中的外部噪声，特别是通过移动平均和过滤处理不能充分消除的噪声，可以获得高精度目标信号。

公开(公告)号：US07039454B1

公开(公告)日：2006-05-02

申请号：US09937842

申请日：2000-03-24

申请人： Mikihiro Kaga ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Michiyuki Fujiwara

发明人： Mikihiro Kaga ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Michiyuki Fujiwara

IPC分类号： A61B6/00

CPC分类号： A61B5/6814 ,  A61B5/1455 ,  A61B2562/0233 ,  A61B2562/046 ,  G01N21/4795

摘要： A biological optical measuring instrument comprising a measuring probe (101) for collecting light from a plurality of portions of a subject (214) transmitted through the subject (214) by means of an optical fiber (108) by guiding light emitted from a light source (102) by an optical fiber (107), and irradiating the light to the subject (214) so as to create a living body transmitted light intensity image of the subject (214) from the transmitted and collected light. The measuring probe (101) further comprises optical fiber fixing members (201, 210, 211) for fixing the optical fibers (107, 108) at a predetermined interval and support members (202, 204, 205) for rockably supporting the optical fiber fixing members. Thus, it is possible to provide a technique of performing living body optical measurement while the living body lies in lateral decubitus.

摘要翻译： 一种生物光学测量仪器，包括测量探针（101），用于通过引导从光源发出的光来收集来自通过对象（214）的被摄体（214）的多个部分的光 （102），并且将光照射到被摄体（214），以从所发射和收集的光中产生对象（214）的活体透射光强度图像。 测量探针（101）还包括用于以预定间隔固定光纤（107,108）的光纤固定构件（201,210,211）和支撑构件（202,204,205），用于可摆动地支撑光纤固定 会员 因此，可以提供一种在活体位于侧卧位时进行生物体光学测量的技术。

公开(公告)号：US07778694B2

公开(公告)日：2010-08-17

申请号：US11355017

申请日：2006-02-16

申请人： Mikihiro Kaga ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Michiyuki Fujiwara

发明人： Mikihiro Kaga ,  Noriyoshi Ichikawa ,  Fumio Kawaguchi ,  Michiyuki Fujiwara

IPC分类号： A61B6/00

CPC分类号： A61B5/6814 ,  A61B5/1455 ,  A61B2562/0233 ,  A61B2562/046 ,  G01N21/4795

摘要： A biological optical measurement instrument including: a measurement probe positionable to a surface of a subject, which irradiates light beams having a plurality of wavelengths from a light beam source through optical fibers onto the subject, and collects the light beams passed inside the subject from a plurality of positions to facilitate production of diagnostics from collected light beams of the subject, wherein the measurement probe is provided with probe casings which hold the optical fibers, fixing members where each respective fixing member is mateable with a respective probe casing to position the probe casings in a predetermined interval, and a support member which supports the fixing members, and wherein at least one of the respective probe casing or the respective fixing member is provided with a stopper claw to permit fixed engagement of the respective probe casing with the respective fixing member upon mating thereof.

摘要翻译： 一种生物学光学测量仪器，包括：测量探针，其可定位到被检体的表面，其将来自光束源的多个波长的光束通过光纤照射到所述被检体上，并且从所述被检体的内部收集通过所述被检体内的光束 多个位置以便于从被检体的收集的光束产生诊断，其中测量探针设置有保持光纤的探针壳体，固定构件，其中每个相应的固定构件可与相应的探针壳体配合，以将探针壳体 以及支撑固定构件的支撑构件，并且其中各个探针壳体或相应的固定构件中的至少一个设置有止动爪，以允许各个探针壳体与相应的固定构件的固定接合 在交配时。