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公开(公告)号：US5460814A
公开(公告)日：1995-10-24
申请号：US228712
申请日：1994-04-18
申请人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
发明人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
IPC分类号： C07D493/04 , C12P17/18 , C12N1/16 , C12P1/02
CPC分类号： C07D493/04 , C12P17/181 , C12R1/645
摘要： The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producing the compounds A and/or B by using the microorganisms, and a treated or untreated fermentation broth obtained by culturing strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain. ##STR1## The present invention provides the compounds A and B, derivatives thereof, and treated or untreated fermentation broth obtained by culturing the strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain, which show an excellent activities as antifungal agent and anti-thrombotic agent.
摘要翻译： 本发明涉及式（A）化合物A，相关化合物B，衍生自这些化合物的酸酐基团的羧酸及其酯和盐，用于制备化合物的微生物，化合物A和/ 或B，以及通过培养属于Zopfiella属或No.37-3菌株的菌株获得的处理或未处理的发酵肉汤。 （A）本发明提供了化合物A和B及其衍生物，以及通过培养属于Zopfiella属或曲霉菌株37-3株的菌株获得的处理或未处理的发酵液，其显示出优异的活性 抗真菌剂和抗血栓形成剂。
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公开(公告)号：US5346919A
公开(公告)日：1994-09-13
申请号：US100171
申请日：1993-08-02
申请人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
发明人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
IPC分类号： C07D493/04 , C12P17/18 , A61K31/34 , C07D307/93 , C12P7/40
CPC分类号： C07D493/04 , C12P17/181 , C12R1/645
摘要： The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producing the compounds A and/or B by using the microorganisms, and a treated or untreated fermentation broth obtained by culturing strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain. ##STR1## The present invention provides the compounds A and B, derivatives thereof, and treated or untreated fermentation broth obtained by culturing the strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain, which show an excellent activities as antifungal agent and anti-thrombotic agent.
摘要翻译： 本发明涉及式（A）化合物A，相关化合物B，衍生自这些化合物的酸酐基团的羧酸及其酯和盐，用于制备化合物的微生物，化合物A和/ 或B，以及通过培养属于Zopfiella属或No.37-3菌株的菌株获得的处理或未处理的发酵肉汤。 （A）本发明提供了化合物A和B及其衍生物，以及通过培养属于Zopfiella属或曲霉菌株37-3株的菌株获得的处理或未处理的发酵液，其显示出优异的活性 抗真菌剂和抗血栓形成剂。
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公开(公告)号：US5081024A
公开(公告)日：1992-01-14
申请号：US396694
申请日：1989-08-22
CPC分类号： C12P41/007 , C12P13/04 , Y10S435/824 , Y10S435/827 , Y10S435/829 , Y10S435/833 , Y10S435/85 , Y10S435/881 , Y10S435/883 , Y10S435/907
摘要： An efficient process of optical resolution is provided for producing an L-amino acid represented by the following formula (I): ##STR1## wherein R is --CH.sub.2 CO.sub.2 H, --CH.sub.2 CONH.sub.2, --CO.sub.2 H or ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group having 1 to 10 carbon atoms or a halogen-substituted alkyl group having 1 to 10 carbon atoms. The process comprises an optical resolution of an N-substituted carbonyl-D,L-amino acid represented by the formula (II): ##STR3## (wherein R is the same as defined above and R.sup.2 is an alkanoyl group having 1 to 5 carbon atoms, benzoyl group, a halogen-substituted alkanoyl group having 1 to 5 carbon atoms or a halogen-substituted benzoyl group), its salt or a mixture thereof, by means of cells of a microorganism, a fermentation broth of a microorganism, a treated fermentation broth of a microorganism or a mixture thereof, said microorganism being selected from the bacteria of the genera Serratia, Staphylococcus, Bacillus, Flavobacterium, Achromobacter and Alcaligenes and actinomycetes of the genera Actinoplanes, Streptosporangium and Sebekia.
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