公开(公告)号：US20180201908A1

公开(公告)日：2018-07-19

申请号：US15315687

申请日：2015-06-19

申请人： UNIVERSITÉ D'AIX-MARSEILLE ,  INSERM

发明人： Antoine Nougairéde ,  Lauriane De Fabritus ,  Fabien Aubry ,  Xavier De Lamballerie ,  Ernest Andrew Gould

IPC分类号： C12N7/04 ,  C12N15/10 ,  A61K39/12

CPC分类号： C12N7/04 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5254 ,  C12N7/00 ,  C12N15/1031 ,  C12N2770/24051 ,  C12N2770/24151 ,  Y02A50/383 ,  Y02A50/39 ,  Y02A50/396

摘要： The present invention harnesses the power of mutagenesis to produce an attenuated RNA virus in a very short period, i.e. as soon as the complete sequence of the target virus is known and an infectious genome can be produced.

公开(公告)号：US20180208907A1

公开(公告)日：2018-07-26

申请号：US15315667

申请日：2015-06-19

申请人： UNIVERSITÉ D'AIX-MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

发明人： Fabien Aubry ,  Antoine Nougairéde ,  Gilles Quérat ,  Xavier De Lamballerie ,  Ernest Andrew Gould ,  Lauriane De Fabritus

IPC分类号： C12N7/02

CPC分类号： C12N7/02 ,  A61K2039/525 ,  C12N7/00 ,  C12N2770/24051 ,  C12N2770/24151 ,  C12N2999/007 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396 ,  Y02A50/51

摘要： The present invention relates to a method for rapid generation of an infectious RNA virus that completely eliminates the need of constructing a full-length c DNA, which covers the entire viral genome, cloning and propagating such full length c DNA.

公开(公告)号：US20200270584A1

公开(公告)日：2020-08-27

申请号：US16813179

申请日：2020-03-09

申请人： UNIVERSITÉ D'AIX-MARSEILLE ,  INSERM

发明人： Antoine Nougairéde ,  Lauriane De Fabritus ,  Fabien Aubry ,  Xavier De Lamballerie ,  Ernest Andrew Gould

IPC分类号： C12N7/04 ,  C12N7/00 ,  A61K39/12 ,  C12N15/10

摘要： The present invention harnesses the power of mutagenesis to produce an attenuated RNA virus in a very short period, i.e. as soon as the complete sequence of the target virus is known and an infectious genome can be produced.

公开(公告)号：US10407667B2

公开(公告)日：2019-09-10

申请号：US15315667

申请日：2015-06-19

申请人： UNIVERSITÉ D'AIX-MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

发明人： Fabien Aubry ,  Antoine Nougairéde ,  Gilles Quérat ,  Xavier De Lamballerie ,  Ernest Andrew Gould ,  Lauriane De Fabritus

IPC分类号： C12N7/02 ,  C12N7/00 ,  A61K39/00

摘要： The present invention relates to a method for rapid generation of an infectious RNA virus that completely eliminates the need of constructing a full-length c DNA, which covers the entire viral genome, cloning and propagating such full length c DNA.