公开(公告)号：US20150231230A1

公开(公告)日：2015-08-20

申请号：US14617711

申请日：2015-02-09

Applicant: University of Florida Research Foundation, Inc.

Inventor： JANET K. YAMAMOTO

IPC: A61K39/21 ,  G01N33/569 ,  C07K16/10 ,  C12N7/00 ,  A61K45/06 ,  C07K14/005

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  A61K2039/552 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/1045 ,  C07K16/1054 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16222 ,  C12N2740/16234 ,  G01N33/56983 ,  G01N2333/52 ,  G01N2333/57

Abstract: The subject invention concerns methods and materials for inducing an immune response in an animal or person against an immunodeficiency virus, such as HIV, SIV, or FIV. In one embodiment, a method of the invention comprises administering one or more antigens and/or immunogens to the person or animal wherein the antigen and/or immunogen comprises one or more evolutionarily conserved epitopes of immunodeficiency viruses. In one embodiment, the epitope is one that is conserved between HIV and SIV, or between HIV and FIV. In another embodiment, the epitope is one that is conserved between HIV, SIV, and FIV.

Abstract translation: 本发明涉及用于在动物或个人中针对免疫缺陷病毒如HIV，SIV或FIV诱导免疫应答的方法和材料。 在一个实施方案中，本发明的方法包括向人或动物施用一种或多种抗原和/或免疫原，其中所述抗原和/或免疫原包含免疫缺陷病毒的一个或多个进化上保守的表位。 在一个实施方案中，表位是在HIV和SIV之间或在HIV和FIV之间保守的。 在另一个实施方案中，表位是在HIV，SIV和FIV之间保守的表位。

公开(公告)号：US20180333481A1

公开(公告)日：2018-11-22

申请号：US15762108

申请日：2016-09-25

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： JANET K. YAMAMOTO

IPC: A61K39/21 ,  A61K9/00 ,  C07K14/005 ,  A61P31/14 ,  A61P31/18

Abstract: The subject invention concerns methods and materials for inducing an immune response in an animal or person against an immunodeficiency virus, such as HIV, SIV, or FIV. In one embodiment, a method of the invention comprises administering one or more antigens and/or immunogens to the person or animal wherein the antigen and/or immunogen comprises one or more evolutionarily conserved epitopes of immunodeficiency viruses. In one embodiment, the epitope is one that is conserved between HIV and FIV.

公开(公告)号：US20180228890A1

公开(公告)日：2018-08-16

申请号：US15881148

申请日：2018-01-26

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： JANET K. YAMAMOTO

IPC: A61K39/21 ,  A61K45/06 ,  C07K16/10 ,  C12N7/00 ,  G01N33/569

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  A61K2039/552 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/1045 ,  C07K16/1054 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16222 ,  C12N2740/16234 ,  G01N33/56983 ,  G01N2333/52 ,  G01N2333/57

Abstract: The subject invention concerns methods and materials for inducing an immune response in an animal or person against an immunodeficiency virus, such as HIV, SIV, or FIV. In one embodiment, a method of the invention comprises administering one or more antigens and/or immunogens to the person or animal wherein the antigen and/or immunogen comprises one or more evolutionarily conserved epitopes of immunodeficiency viruses. In one embodiment, the epitope is one that is conserved between HIV and SIV, or between HIV and FIV. In another embodiment, the epitope is one that is conserved between HIV, SIV, and FIV.

公开(公告)号：US20210386851A1

公开(公告)日：2021-12-16

申请号：US17444242

申请日：2021-08-02

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： JANET K. YAMAMOTO

IPC: A61K39/21 ,  A61K39/12 ,  A61K39/295 ,  C07K14/16

Abstract: The subject invention pertains to materials and methods for detecting, preventing and treating retroviral infections in humans and other animals susceptible to infection by retrovirus. It has been discovered that FIV can be transmitted from cats to humans and that the FIV can infect human cells in vivo and that antibodies generated by the infected person cross-react with HIV antigens. Thus, the methods and compositions of the subject invention can be used to detect, prevent and treat FIV infection in humans and other non-feline animals that are susceptible to FIV infection. The methods and compositions of the invention can also be used to prevent and treat infection by HIV in humans.

公开(公告)号：US20150098965A1

公开(公告)日：2015-04-09

申请号：US14511864

申请日：2014-10-10

Applicant: University Of Florida Research Foundation, Inc.

Inventor： JANET K. YAMAMOTO

IPC: A61K39/21

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K2039/575 ,  A61K2039/58 ,  A61K2039/70 ,  C12N2740/15034 ,  C12Q1/702 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6854 ,  G01N2333/155 ,  G01N2469/20

Abstract: The subject invention pertains to materials and methods for detecting, preventing and treating retroviral infections in humans and other animals susceptible to infection by retrovirus. It has been discovered that FIV can be transmitted from cats to humans and that the FIV can infect human cells in vivo and that antibodies generated by the infected person cross-react with HIV antigens. Thus, the methods and compositions of the subject invention can be used to detect, prevent and treat FIV infection in humans and other non-feline animals that are susceptible to FIV infection. The methods and compositions of the invention can also be used to prevent and treat infection by HIV in humans.

Abstract translation: 本发明涉及用于检测，预防和治疗易感染逆转录病毒的人和其他动物中的逆转录病毒感染的材料和方法。 已经发现FIV可以从猫传播到人，并且FIV可以在体内感染人类细胞，并且感染者产生的抗体与HIV抗原交叉反应。 因此，本发明的方法和组合物可用于检测，预防和治疗对FIV感染易感的人和其它非猫科动物中的FIV感染。 本发明的方法和组合物也可用于预防和治疗人类中HIV的感染。