公开(公告)号：US11602739B2

公开(公告)日：2023-03-14

申请号：US17259282

申请日：2019-07-22

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

Inventor： Bo Xu ,  Zhichao Lu ,  Gerald B. Hammond

IPC: B01J31/08 ,  B01J37/26 ,  B01J37/30 ,  B01J41/04 ,  B01J41/12 ,  B01J47/02 ,  C07B39/00 ,  C07C67/287 ,  C07C209/74 ,  C07D213/803 ,  C07D309/08

Abstract: Some embodiments of the invention include inventive catalysts (e.g., catalysts of Formula (I)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.

公开(公告)号：US20150238439A1

公开(公告)日：2015-08-27

申请号：US14426399

申请日：2013-09-06

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

Inventor： Francesca R. Salipur ,  Paula J. Bates ,  Elsa Merit Reyes-Reyes ,  Bo Xu ,  Gerald B. Hammond

IPC: A61K31/045 ,  A61K38/06 ,  A61K31/22 ,  A61K31/198

CPC classification number: A61K31/045 ,  A61K31/198 ,  A61K31/22 ,  A61K38/063 ,  A61K45/06 ,  A61K2300/00

Abstract: Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.

Abstract translation: 本发明的一些方面包括减轻动物中的DNMT1抑制剂活性，包括施用抗氧化剂。 本发明的其它方面包括施用包含DNMT1抑制剂和抗氧化剂的组合物的方法。 在这些方法的某些情况下，动物正在接受癌症治疗。 本发明的另外的方面包括含有DNMT1抑制剂和抗氧化剂的组合物。

公开(公告)号：US20190176134A1

公开(公告)日：2019-06-13

申请号：US16214793

申请日：2018-12-10

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

Inventor： Bo Xu ,  Zhichao Lu ,  Gerald B. Hammond

IPC: B01J27/055 ,  C01D5/00 ,  C07C67/287 ,  C07C303/30 ,  C07D209/50 ,  C07C303/34 ,  C07C201/12 ,  C07C213/08 ,  C07C253/30 ,  C07C45/63 ,  C07D215/227 ,  C07D307/68 ,  C07D333/38 ,  C07D207/34 ,  C07D277/56

Abstract: Some embodiments of the invention include inventive catalysts (e.g., compounds of Formula (I) or (Ia)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.

公开(公告)号：US09737493B2

公开(公告)日：2017-08-22

申请号：US14426399

申请日：2013-09-06

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Francesca R. Salipur ,  Paula J. Bates ,  Elsa Merit Reyes-Reyes ,  Bo Xu ,  Gerald B. Hammond

IPC: A61K31/45 ,  A61K31/198 ,  A61K31/045 ,  A61K45/06 ,  A61K31/22 ,  A61K38/06

CPC classification number: A61K31/045 ,  A61K31/198 ,  A61K31/22 ,  A61K38/063 ,  A61K45/06 ,  A61K2300/00

Abstract: Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.

公开(公告)号：US10702858B2

公开(公告)日：2020-07-07

申请号：US16214793

申请日：2018-12-10

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

Inventor： Bo Xu ,  Zhichao Lu ,  Gerald B. Hammond

IPC: B01J27/055 ,  C07D277/56 ,  C07C67/287 ,  C07C303/30 ,  C07D209/50 ,  C07C303/34 ,  C07C201/12 ,  C07C213/08 ,  C07C253/30 ,  C07C45/63 ,  C07D215/227 ,  C07D307/68 ,  C07D333/38 ,  C07D207/34 ,  C01D5/00 ,  C07C17/087 ,  C07C67/307 ,  C07C51/363 ,  C07B39/00 ,  C07C29/62 ,  B01J31/00

Abstract: Some embodiments of the invention include inventive catalysts (e.g., compounds of Formula (I) or (Ia)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.