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1.发明申请公开(公告)号：US20150025129A1
公开(公告)日：2015-01-22
申请号：US14358731
申请日：2012-11-16
Applicant: University of Louisville Research Foundation, Inc , Laboratorios de Investigacion y Desarrollo: Facult de Ciencias y Filosofia
Inventor： Gerald B. Hammond , Zhuang Jin , Paula J. Bates , Elsa Merit Reyes-Reyes , Abraham Vaisberg
IPC: A61K31/366 , A61K36/81
CPC classification number: A61K31/366 , A61K36/81
Abstract: Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
Abstract translation: 本发明的某些实施方案包括包含式（I）化合物及其盐，异构体及其衍生物的组合物。 本发明一些实施方案的药物组合物包含式（I）化合物及其盐，异构体及其衍生物。 本发明的其它实施方案包括治疗疾病（例如癌症）的方法和给予式（I）化合物及其盐，异构体及其衍生物的方法。
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公开(公告)号：US11602739B2
公开(公告)日：2023-03-14
申请号：US17259282
申请日：2019-07-22
Inventor： Bo Xu , Zhichao Lu , Gerald B. Hammond
IPC: B01J31/08 , B01J37/26 , B01J37/30 , B01J41/04 , B01J41/12 , B01J47/02 , C07B39/00 , C07C67/287 , C07C209/74 , C07D213/803 , C07D309/08
Abstract: Some embodiments of the invention include inventive catalysts (e.g., catalysts of Formula (I)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.
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Patent Agency Ranking
3.发明授权公开(公告)号：US09492428B2
公开(公告)日：2016-11-15
申请号：US14358731
申请日：2012-11-16
Inventor： Gerald B. Hammond , Zhuang Jin , Paula J. Bates , Elsa Merit Reyes-Reyes , Abraham Vaisberg
IPC: A61K31/366 , A61K36/81
CPC classification number: A61K31/366 , A61K36/81
Abstract: Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
Abstract translation: 本发明的某些实施方案包括包含式（I）化合物及其盐，异构体及其衍生物的组合物。 本发明一些实施方案的药物组合物包含式（I）化合物及其盐，异构体及其衍生物。 本发明的其它实施方案包括治疗疾病（例如癌症）的方法和给予式（I）化合物及其盐，异构体及其衍生物的方法。
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公开(公告)号：US20150238439A1
公开(公告)日：2015-08-27
申请号：US14426399
申请日：2013-09-06
Inventor： Francesca R. Salipur , Paula J. Bates , Elsa Merit Reyes-Reyes , Bo Xu , Gerald B. Hammond
IPC: A61K31/045 , A61K38/06 , A61K31/22 , A61K31/198
CPC classification number: A61K31/045 , A61K31/198 , A61K31/22 , A61K38/063 , A61K45/06 , A61K2300/00
Abstract: Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.
Abstract translation: 本发明的一些方面包括减轻动物中的DNMT1抑制剂活性，包括施用抗氧化剂。 本发明的其它方面包括施用包含DNMT1抑制剂和抗氧化剂的组合物的方法。 在这些方法的某些情况下，动物正在接受癌症治疗。 本发明的另外的方面包括含有DNMT1抑制剂和抗氧化剂的组合物。
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公开(公告)号：US20190176134A1
公开(公告)日：2019-06-13
申请号：US16214793
申请日：2018-12-10
Inventor： Bo Xu , Zhichao Lu , Gerald B. Hammond
IPC: B01J27/055 , C01D5/00 , C07C67/287 , C07C303/30 , C07D209/50 , C07C303/34 , C07C201/12 , C07C213/08 , C07C253/30 , C07C45/63 , C07D215/227 , C07D307/68 , C07D333/38 , C07D207/34 , C07D277/56
Abstract: Some embodiments of the invention include inventive catalysts (e.g., compounds of Formula (I) or (Ia)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.
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公开(公告)号：US09737493B2
公开(公告)日：2017-08-22
申请号：US14426399
申请日：2013-09-06
Inventor： Francesca R. Salipur , Paula J. Bates , Elsa Merit Reyes-Reyes , Bo Xu , Gerald B. Hammond
IPC: A61K31/45 , A61K31/198 , A61K31/045 , A61K45/06 , A61K31/22 , A61K38/06
CPC classification number: A61K31/045 , A61K31/198 , A61K31/22 , A61K38/063 , A61K45/06 , A61K2300/00
Abstract: Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.
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公开(公告)号：US10702858B2
公开(公告)日：2020-07-07
申请号：US16214793
申请日：2018-12-10
Inventor： Bo Xu , Zhichao Lu , Gerald B. Hammond
IPC: B01J27/055 , C07D277/56 , C07C67/287 , C07C303/30 , C07D209/50 , C07C303/34 , C07C201/12 , C07C213/08 , C07C253/30 , C07C45/63 , C07D215/227 , C07D307/68 , C07D333/38 , C07D207/34 , C01D5/00 , C07C17/087 , C07C67/307 , C07C51/363 , C07B39/00 , C07C29/62 , B01J31/00
Abstract: Some embodiments of the invention include inventive catalysts (e.g., compounds of Formula (I) or (Ia)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.
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