公开(公告)号：US20240239730A1

公开(公告)日：2024-07-18

申请号：US18618449

申请日：2024-03-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07B2200/07 ,  C07C2601/16

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US20240197891A1

公开(公告)日：2024-06-20

申请号：US18554917

申请日：2022-04-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Thomas CHEN

IPC: A61K47/55 ,  A61K8/37 ,  A61P17/02 ,  A61Q17/04

CPC classification number: A61K47/55 ,  A61K8/37 ,  A61P17/02 ,  A61Q17/04

Abstract: The present invention provides a method for treating inflammation in a mammal. The method includes delivering to the mammal a therapeutically effective amount of a composition including a perillyl alcohol (POH) conjugated with linoleic acid. The present invention also provides a method for treating or preventing damage from UV exposure in a mammal.

公开(公告)号：US20240016800A1

公开(公告)日：2024-01-18

申请号：US18461562

申请日：2023-09-06

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Thomas CHEN

IPC: A61K31/495 ,  C07D231/12 ,  A61K31/4188 ,  A61K47/54 ,  C07B59/00 ,  A61K31/4015 ,  A61K9/00 ,  A61K31/045 ,  A61K31/415 ,  C07D207/26 ,  C07C33/14 ,  C07D487/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/635 ,  A61K47/55 ,  A61K31/366

CPC classification number: A61K31/495 ,  C07D231/12 ,  A61K31/4188 ,  A61K47/543 ,  C07B59/00 ,  A61K31/4015 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/415 ,  C07D207/26 ,  C07C33/14 ,  A61K47/542 ,  A61K47/54 ,  C07D487/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/635 ,  A61K47/55 ,  A61K31/366 ,  C07C2601/16 ,  C07B2200/05

Abstract: The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.