公开(公告)号：US20140236002A1

公开(公告)日：2014-08-21

申请号：US14349603

申请日：2012-10-17

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Ruikang Wang ,  Murray Johnstone ,  Tueng T. Shen

IPC: A61B3/10 ,  A61B5/0205 ,  A61B5/00

CPC classification number: A61B3/102 ,  A61B5/0066 ,  A61B5/0205 ,  A61B5/7235 ,  A61B5/7275

Abstract: A system and method for measuring tissue motion within a living tissue of the anterior segment and aqueous outflow system of the eye in a subject are provided. Tissue movements are extracted from a plurality of images acquired from the living tissue using an optical coherence tomography system. The images may be corrected using motion compensation. To extract the tissue movements from the images, waves from a cardiac pulse or other externally induced pulses from the subject are acquired, and a pulse wave is defined for a given time, which is then correlated with a velocity wave defined for a velocity of tissue and/or fluid movement within the tissue region for the same given time. Pulsatile motion is then isolated in the tissue region from the plurality of images.

Abstract translation: 本发明提供了一种用于测量受试者眼部前段和水流出系统的生物体组织运动的系统和方法。 使用光学相干断层摄影系统从从活体组织获取的多个图像中提取组织移动。 可以使用运动补偿来校正图像。 为了从图像中提取组织移动，获取来自受试者的心脏脉搏或其他外部诱发脉冲的波，并且在给定时间内定义脉搏波，然后将其与为组织速度定义的速度波相关联 和/或在相同给定时间内的组织区域内的流体运动。 然后在多个图像的组织区域中隔离脉动运动。

公开(公告)号：US09759544B2

公开(公告)日：2017-09-12

申请号：US14821535

申请日：2015-08-07

Applicant: Carl Zeiss Meditec, Inc. ,  University of Washington through its Center for Commercialization

Inventor： Lin An ,  Ruikang Wang ,  Utkarsh Sharma

IPC: G01B11/02 ,  G01B9/02 ,  A61B3/10 ,  A61B3/00

CPC classification number: G01B9/02077 ,  A61B3/0025 ,  A61B3/102 ,  G01B9/02085 ,  G01B9/02091

Abstract: A method for reducing motion artifacts in optical coherence tomography (OCT) angiography images is disclosed. The method is applied to the intensity or complex OCT data prior to applying the motion contrast analysis and involves determining sub-pixel level shifts between at least two B-scans repeated approximately at the same location and applying the sub-pixel level shifts to the B-scans to be able to correct for motion and accurately determine motion contrast signal. A preferred embodiment includes the use of 2D cross correlations to register a series of B-scans in both the axial (z-) and lateral (x-) dimensions and a convolution approach to achieve sub-pixel level frame registration.

公开(公告)号：US20150011895A1

公开(公告)日：2015-01-08

申请号：US14371337

申请日：2013-03-28

Applicant: University of Washington Through Its Center for Commercialization

Inventor： Murray Johnstone ,  Ruikang Wang

IPC: A61B5/00

CPC classification number: A61B5/0051 ,  A61B5/0066

Abstract: Systems and methods for determining mechanical properties of a biological tissue in a subject are provided. A low coherence optical interferometer detects waves generated from a surface of a tissue in a subject. The waves are generated from elastographic deformation of the tissue induced by an impulse stimulation. Phase velocities can then be determined from the waves, and elastographic properties from the phase velocities, including an elasticity value for a portion of the surface of the tissue.

Abstract translation: 提供了用于确定受试者中的生物组织的机械性质的系统和方法。 低相干光干涉仪检测从受试者的组织表面产生的波。 由脉冲刺激引起的组织的弹性变形产生波。 然后可以从波中确定相速度，以及来自相速度的弹性特性，包括组织表面的一部分的弹性值。