公开(公告)号：US20180024121A1

公开(公告)日：2018-01-25

申请号：US15536558

申请日：2015-12-18

Applicant: UPM-KYMMENE CORPORATION

Inventor： Marjo Yliperttula ,  Arto Urtti ,  Yan-Ru Lou ,  Melina Malinen ,  Patrick Laurén ,  Liisa Kanninen ,  Johanna Niklander ,  Petter Somersalo ,  Riina Harjumäki

IPC: G01N33/50

CPC classification number: G01N33/5082 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5023 ,  G01N33/5026 ,  G01N33/5436 ,  G01N2800/52

Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical;optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.

公开(公告)号：US11969505B2

公开(公告)日：2024-04-30

申请号：US17712732

申请日：2022-04-04

Applicant: UPM-KYMMENE CORPORATION

Inventor： Heli Paukkonen ,  Vili-Veli Auvinen ,  Marjo Yliperttula ,  Patrick Laurën ,  Arto Urtti ,  Timo Laaksonen ,  Arto Merivaara ,  Tiina Hakkarainen ,  Outi Monni ,  Anne Mäkelä ,  Petter Somersalo ,  Piia-Riitta Karhemo ,  Heikki Joensuu ,  Raili Koivuniemi ,  Kari Luukko ,  Markus Nuopponen

IPC: A01N1/02 ,  A61K9/06 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38 ,  C12N5/00 ,  C12N5/09 ,  F26B5/06

CPC classification number: A61K9/19 ,  A01N1/0221 ,  A01N1/0231 ,  A61K9/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38 ,  C12N5/0062 ,  C12N5/0693 ,  F26B5/06 ,  C12N2513/00 ,  C12N2533/78

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

公开(公告)号：US10976308B2

公开(公告)日：2021-04-13

申请号：US15536558

申请日：2015-12-18

Applicant: UPM-KYMMENE CORPORATION

Inventor： Marjo Yliperttula ,  Arto Urtti ,  Yan-Ru Lou ,  Melina Malinen ,  Patrick Laurén ,  Liisa Kanninen ,  Kirsti Johanna Niklander ,  Petter Somersalo ,  Riina Harjumäki

IPC: G01N33/50 ,  G01N33/543 ,  C12N5/00 ,  C12N5/0735

Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.

公开(公告)号：US11850306B2

公开(公告)日：2023-12-26

申请号：US16468979

申请日：2017-12-15

Applicant: UPM-KYMMENE CORPORATION

Inventor： Vili-Veli Auvinen ,  Heli Paukkonen ,  Marjo Yliperttula ,  Arto Urtti ,  Tiina Hakkarainen ,  Patrick Laurén ,  Mikko Kunnari ,  Timo Laaksonen ,  Mingwei Li ,  Kari Luukko

IPC: A61K9/19 ,  A61K47/38 ,  A61K47/10 ,  A61K47/26 ,  A61K9/06 ,  A01N1/02 ,  C12N5/00 ,  C12N5/09 ,  F26B5/06

CPC classification number: A61K9/19 ,  A01N1/0221 ,  A01N1/0231 ,  A61K9/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38 ,  C12N5/0062 ,  C12N5/0693 ,  F26B5/06 ,  C12N2513/00 ,  C12N2533/78

Abstract: The present disclosure relates to method for drying hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a freeze-dryable hydrogel comprising nanofibrillar cellulose, to a freeze-dried hydrogel comprising nanofibrillar cellulose, and to a medical hydrogel comprising nanofibrillar cellulose and one or more therapeutic agent(s).

公开(公告)号：US11324701B2

公开(公告)日：2022-05-10

申请号：US16468390

申请日：2017-08-25

Applicant: UPM-KYMMENE CORPORATION

Inventor： Heli Paukkonen ,  Vili-Veli Auvinen ,  Marjo Yliperttula ,  Patrick Laurén ,  Arto Urtti ,  Timo Laaksonen ,  Arto Merivaara ,  Tiina Hakkarainen ,  Outi Monni ,  Anne Mäkelä ,  Petter Somersalo ,  Piia-Riitta Karhemo ,  Heikki Joensuu ,  Raili Koivuniemi ,  Kari Luukko ,  Markus Nuopponen

IPC: A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38 ,  A01N1/02 ,  C12N5/00 ,  C12N5/09 ,  A61K9/06 ,  F26B5/06

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

公开(公告)号：US20210190765A1

公开(公告)日：2021-06-24

申请号：US17190351

申请日：2021-03-02

Applicant: UPM-KYMMENE CORPORATION

Inventor： Marjo Yliperttula ,  Arto Urtti ,  Yan-Ru Lou ,  Melina Malinen ,  Patrick Laurén ,  Liisa Kanninen ,  Kirsti Johanna Niklander ,  Petter Somersalo ,  Riina Harjumäki

IPC: G01N33/50 ,  G01N33/543 ,  C12N5/00 ,  C12N5/0735

Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC)hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.