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公开(公告)号：US11602566B2
公开(公告)日：2023-03-14
申请号：US16771518
申请日：2019-03-01
Applicant: UPM-Kymmene Corporation
Inventor： Kari Luukko , Markus Nuopponen , Nicolò Curzio , Marjo Yliperttula , Polina Ilina , Päivi Tammela
Abstract: The present application provides a method for preparing a medical product for covering tissue, the method comprising providing nanofibrillar cellulose, providing a bioactive molecule, and covalently bonding the bioactive molecule to the nanofibrillar cellulose. The present application also provides a medical product for covering tissue comprising a bioactive molecule covalently bound to nanofibrillar cellulose.
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公开(公告)号：US20220349651A1
公开(公告)日：2022-11-03
申请号：US17245445
申请日：2021-04-30
Applicant: UPM-Kymmene Corporation
Inventor： Markus Nuopponen , Marjo Yliperttula , Arto Merivaara , Ossi Korhonen , Jacopo Zini , Elle Koivunotko , Lisa Chinello , Giulia Scapin , Anne Meriluoto , Lauri Paasonen
Abstract: A method for freeze-drying a hydrogel composition is disclosed, the method comprising providing the hydrogel composition, wherein the hydrogel composition comprises cellulose nanofibrils and/or cellulose nanocrystals, at least one saccharide, at least one amino acid, and biologics; and freeze-drying the hydrogel composition, thereby obtaining a freeze-dried hydrogel composition.
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公开(公告)号：US20180024121A1
公开(公告)日：2018-01-25
申请号：US15536558
申请日：2015-12-18
Applicant: UPM-KYMMENE CORPORATION
Inventor： Marjo Yliperttula , Arto Urtti , Yan-Ru Lou , Melina Malinen , Patrick Laurén , Liisa Kanninen , Johanna Niklander , Petter Somersalo , Riina Harjumäki
IPC: G01N33/50
CPC classification number: G01N33/5082 , G01N33/5008 , G01N33/5014 , G01N33/5023 , G01N33/5026 , G01N33/5436 , G01N2800/52
Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical;optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.
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公开(公告)号：US20180021473A1
公开(公告)日：2018-01-25
申请号：US15550173
申请日：2016-02-10
Applicant: UPM-KYMMENE CORPORATION
Inventor： Marjo Yliperttula , Patrick Lauren , Petter Somersalo , Yanru Lou
IPC: A61L17/14 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/16 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/14 , A61L27/26 , A61L29/08
CPC classification number: A61L17/145 , A61L27/26 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/145 , A61L29/148 , A61L29/16 , A61L31/041 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , C08B1/003 , C08B37/0084 , C08L1/02 , C08L5/04
Abstract: The present invention relates to the use of nanofibrillar cellulose hydrogel in cell culture and medical applications. The invention relates to a composition comprising nanofibrillar cellulose, cross linkable polymer and at least one bioactive agent. The invention also provides methods for producing the composition and uses thereof. The present invention further relates to the use of said composition for manufacturing of a shaped matrix, the method of preparing said matrix, the matrix and the use of said matrix in various applications.
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公开(公告)号：US10729804B2
公开(公告)日：2020-08-04
申请号：US15550173
申请日：2016-02-10
Applicant: UPM-KYMMENE CORPORATION
Inventor： Marjo Yliperttula , Patrick Lauren , Petter Somersalo , Yanru Lou
IPC: C08L5/04 , A61L17/14 , A61L27/26 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/14 , A61L31/16 , C08B1/00 , C08B37/00 , C08L1/02
Abstract: The present invention relates to the use of nanofibrillar cellulose hydrogel in cell culture and medical applications. The invention relates to a composition comprising nanofibrillar cellulose, cross linkable polymer and at least one bioactive agent. The invention also provides methods for producing the composition and uses thereof. The present invention further relates to the use of said composition for manufacturing of a shaped matrix, the method of preparing said matrix, the matrix and the use of said matrix in various applications.
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Patent Agency Ranking
公开(公告)号：US20160325006A1
公开(公告)日：2016-11-10
申请号：US15109068
申请日：2014-12-30
Applicant: UPM-KYMMENE CORPORATION
Inventor： Antti Laukkanen , Marjo Yliperttula , Carolina Gandia-Ventura , Carmen Escobedo-Lucea , Jouni Paltakari , Marko Bessonoff
CPC classification number: A61L15/28 , A61F13/00012 , A61F13/00063 , A61F13/00987 , A61F2013/00157 , A61L15/225 , A61L15/36 , A61L15/42 , A61L15/44 , A61L27/20 , A61L27/3834 , A61L2300/64 , A61L2400/12 , A61L2400/18 , C08L1/02
Abstract: The present invention is related to a patterned membrane comprising nanofibrillar polysaccharides, device and compositions for improving wound healing, as well as to their manufacture and use for therapy.
Abstract translation: 本发明涉及包含纳米纤丝多糖的图案化膜，用于改善伤口愈合的装置和组合物，以及其制造和用于治疗。
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公开(公告)号：US11969505B2
公开(公告)日：2024-04-30
申请号：US17712732
申请日：2022-04-04
Applicant: UPM-KYMMENE CORPORATION
Inventor： Heli Paukkonen , Vili-Veli Auvinen , Marjo Yliperttula , Patrick Laurën , Arto Urtti , Timo Laaksonen , Arto Merivaara , Tiina Hakkarainen , Outi Monni , Anne Mäkelä , Petter Somersalo , Piia-Riitta Karhemo , Heikki Joensuu , Raili Koivuniemi , Kari Luukko , Markus Nuopponen
IPC: A01N1/02 , A61K9/06 , A61K9/19 , A61K47/10 , A61K47/26 , A61K47/38 , C12N5/00 , C12N5/09 , F26B5/06
CPC classification number: A61K9/19 , A01N1/0221 , A01N1/0231 , A61K9/06 , A61K47/10 , A61K47/26 , A61K47/38 , C12N5/0062 , C12N5/0693 , F26B5/06 , C12N2513/00 , C12N2533/78
Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.
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公开(公告)号：US10976308B2
公开(公告)日：2021-04-13
申请号：US15536558
申请日：2015-12-18
Applicant: UPM-KYMMENE CORPORATION
Inventor： Marjo Yliperttula , Arto Urtti , Yan-Ru Lou , Melina Malinen , Patrick Laurén , Liisa Kanninen , Kirsti Johanna Niklander , Petter Somersalo , Riina Harjumäki
IPC: G01N33/50 , G01N33/543 , C12N5/00 , C12N5/0735
Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.
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公开(公告)号：US09593304B2
公开(公告)日：2017-03-14
申请号：US14430833
申请日：2013-09-24
Applicant: UPM-Kymmene Corporation
Inventor： Antti Laukkanen , Yan-Ru Lou , Marjo Yliperttula , Tytti Kuisma , Johanna Nikander , Jaakko Pere
IPC: C12N5/02 , C12N5/071 , C12N5/00 , C12N5/0735 , C12N5/074
CPC classification number: C12N5/0602 , C12N5/0062 , C12N5/0606 , C12N5/0696 , C12N2500/92 , C12N2533/78
Abstract: The present invention is related to methods and materials for culturing and transporting stem cells in a three-dimensional culture. The materials comprise cellulose nanofibrils in a form of three-dimensional discontinuous entities in a biocompatible hydrogel.
Abstract translation: 本发明涉及在三维培养中培养和输送干细胞的方法和材料。 该材料包括生物相容性水凝胶中三维不连续实体形式的纤维素纳米原纤维。
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公开(公告)号：US20150267164A1
公开(公告)日：2015-09-24
申请号：US14430833
申请日：2013-09-24
Applicant: UPM-KYMMENE CORPORATION
Inventor： Antti Laukkanen , Yan-Ru Lou , Marjo Yliperttula , Tytti Kuisma , Johanna Nikander , Jaakko Pere
IPC: C12N5/071
CPC classification number: C12N5/0602 , C12N5/0062 , C12N5/0606 , C12N5/0696 , C12N2500/92 , C12N2533/78
Abstract: The present invention is related to methods and materials for culturing and transporting stem cells in a three-dimensional culture. The materials comprise cellulose nanofibrils in a form of three-dimensional discontinuous entities in a biocompatible hydrogel.
Abstract translation: 本发明涉及在三维培养中培养和输送干细胞的方法和材料。 该材料包括生物相容性水凝胶中三维不连续实体形式的纤维素纳米原纤维。
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