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公开(公告)号：US11285219B2
公开(公告)日：2022-03-29
申请号：US16745041
申请日：2020-01-16
发明人： Robert H. Zimmer , Gilles Guichard , Juliette Fremaux , Sebastien Goudreau , Claire Venin , Laura Mauran
IPC分类号： A61K47/59 , A61P3/00 , C07K7/02 , C07K14/605 , A61K38/00
摘要： The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.
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公开(公告)号：US20200155637A1
公开(公告)日：2020-05-21
申请号：US16448910
申请日：2019-06-21
IPC分类号： A61K38/06 , A61K47/59 , C07K5/02 , C07K7/02 , C08G69/10 , C08G69/48 , C08L75/02 , A61K38/07 , A61K38/08
摘要： The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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公开(公告)号：US10414722B2
公开(公告)日：2019-09-17
申请号：US15189937
申请日：2016-06-22
发明人： Sebastien Goudreau , Gilles Guichard , Lucile Fischer , Arnaud Salaun , Vincent Diemer , Diane Becart
IPC分类号： C07C275/40 , B01J31/02 , C07C275/30 , C07C335/16 , C07D207/09
摘要： The present description provides oligourea catalysts, a polar helical oligomeric strands, and methods for catalyzing reactions with polar helical oligomeric strands and oligourea catalysts. In particular, the invention relates to a polar helical oligomeric strand of at least 4 residues selected from the formula (I) and which can be used as a catalyst.
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公开(公告)号：US20180244718A1
公开(公告)日：2018-08-30
申请号：US15756513
申请日：2016-08-31
发明人： Gilles Guichard , Gavin W. Colle , Karolina Pulka-ziach , Caterina Maria Lombardo , Juliette Fermaux
CPC分类号： C07K7/02 , A61K38/10 , A61K47/18 , A61K47/59 , C07C275/16 , C07D207/09 , C08L75/02
摘要： The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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公开(公告)号：US20200230249A1
公开(公告)日：2020-07-23
申请号：US16745041
申请日：2020-01-16
发明人： ROBERT H. ZIMMER , Gilles Guichard , Juliette Fremaux , Sebastien Goudreau , Claire Venin , Laura Mauran
摘要： The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.
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公开(公告)号：US10233213B2
公开(公告)日：2019-03-19
申请号：US15756513
申请日：2016-08-31
发明人： Gilles Guichard , Gavin W. Collie , Karolina Pulka-Ziach , Caterina Maria Lombardo , Juliette Fremaux
IPC分类号： A61K38/00 , C07K7/02 , A61K38/10 , A61K47/59 , A61K47/18 , C07C275/16 , C07D207/09 , C08L75/02
摘要： The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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7.发明申请公开(公告)号：US20160368864A1
公开(公告)日：2016-12-22
申请号：US15189937
申请日：2016-06-22
发明人： Sebastien Goudreau , Gilles Guichard , Lucile Fischer , Arnaud Salaun , Vincent Diemer , Diane Becart
IPC分类号： C07C275/40 , B01J31/02
CPC分类号： C07C275/40 , B01J31/0235 , C07C275/30 , C07C335/16 , C07D207/09
摘要： The present description provides oligourea catalysts, a polar helical oligomeric strands, and methods for catalyzing reactions with polar helical oligomeric strands and oligourea catalysts. In particular, the invention relates to a polar helical oligomeric strand of at least 4 residues selected from the formula (I) and which can be used as a catalyst.
摘要翻译： 本说明书提供了寡脲催化剂，极性螺旋低聚链，以及催化与极性螺旋低聚链和低聚脲催化剂反应的方法。 特别地，本发明涉及至少4个选自式（I）的残基并可用作催化剂的极性螺旋低聚物链。
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8.发明申请USE OF MULTIVALENT SYNTHETIC LIGANDS OF SURFACE NUCLEOLIN FOR TREATING CANCER OR INFLAMMATION 审中-公开用于治疗癌症或炎症的表面核素的多种合成配体的使用公开(公告)号：US20160200783A1
公开(公告)日：2016-07-14
申请号：US15000288
申请日：2016-01-19
IPC分类号： C07K14/47
CPC分类号： C07K14/4705 , A61K38/00 , A61K38/02 , A61K38/16 , C07K14/47
摘要： A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a multivalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (I).
摘要翻译： 一种用于治疗涉及细胞增殖和/或血管生成失调的病症的方法，包括施用有效量的多价合成化合物，所述多价合成化合物包含其上至少3个假肽单元被接枝的载体，所述化合物为式（I）。
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公开(公告)号：US20190002519A1
公开(公告)日：2019-01-03
申请号：US16023901
申请日：2018-06-29
申请人： UREKA SARL
IPC分类号： C07K14/605 , A61K47/64 , A61P3/08
摘要： The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved in vivo releasing pep; n≥2 amino acids. The present disclosure also relates to methods of making and using the pro-drug peptide of the present disclosure. For example, the present disclosure describes a pro-drug peptide that may be used to prevent, treat, or ameliorate at least one symptom of hypoglycemia or a hypoglycemia-related disease or disorder.
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公开(公告)号：US20170298112A1
公开(公告)日：2017-10-19
申请号：US15491929
申请日：2017-04-19
申请人： UREKA SARL
发明人： Robert H. Zimmer , Sebastien Goudreau , Gilles Guichard , Juliette Fremaux , Claire Venin , Laura Mauran
IPC分类号： C07K14/605 , G01N33/74 , A61K38/00
摘要： The present description provides compositions and methods for producing therapeutic compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the present disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the present disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
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