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公开(公告)号：US20060002890A1
公开(公告)日：2006-01-05
申请号：US10960851
申请日：2004-10-07
申请人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
发明人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
IPC分类号： A61K31/785 , A61K31/795
CPC分类号： A61K47/60 , A61K31/7088 , A61K31/785 , A61K31/795 , A61K38/28 , A61K47/645 , A61K47/65 , A61K47/6903 , B82Y5/00
摘要： A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
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公开(公告)号：US08450097B2
公开(公告)日：2013-05-28
申请号：US12967285
申请日：2010-12-14
申请人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
发明人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
CPC分类号： B82Y5/00 , A61K47/56 , A61K47/6949 , Y10S977/70 , Y10S977/702 , Y10S977/705 , Y10S977/754
摘要： The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
摘要翻译： 本申请涉及包含连接到核和生物活性部分的超支化聚合物的组合物。 生物活性部分通过基本上非酶切割的接头L连接到芯上。该组合物可用于将生物活性部分递送至其靶。
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公开(公告)号：US07968085B2
公开(公告)日：2011-06-28
申请号：US10960851
申请日：2004-10-07
申请人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
发明人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
IPC分类号： A61K31/785 , A61K31/795 , A61K38/17 , A61K48/00 , A61K38/14 , A61K31/56
CPC分类号： A61K47/60 , A61K31/7088 , A61K31/785 , A61K31/795 , A61K38/28 , A61K47/645 , A61K47/65 , A61K47/6903 , B82Y5/00
摘要： A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
摘要翻译： 包含水凝胶，生物活性部分和可逆前药接头的聚合物前药组合物。 前药接头将水凝胶和生物活性部分共价连接在一个位置，并且水凝胶在其表面上具有多个具有开口的孔。 至少在孔的至少一个开口和生物活性部分的位置之间，孔的直径大于生物活性部分的直径。
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公开(公告)号：US20080241102A1
公开(公告)日：2008-10-02
申请号：US10594097
申请日：2005-03-22
申请人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
发明人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
IPC分类号： A61K38/21 , C07C271/10 , A61K31/27 , C07H21/04 , A61K38/28 , C07K2/00 , A61K31/7052 , A61K38/02
CPC分类号： A61K47/48246 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/643 , A61K47/6903 , C07C69/96 , C07D207/46 , C07D401/12 , C07K14/00 , C07K14/61 , C07K14/62
摘要： A cascade carrier linked prodrug is described which comprises a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
摘要翻译： 描述了级联载体连接的前药，其包含生物活性部分和具有至少一个亲核体并且与载体不同的掩蔽基团。
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公开(公告)号：US20070020224A1
公开(公告)日：2007-01-25
申请号：US10574213
申请日：2004-10-01
申请人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
发明人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
IPC分类号： A61K48/00 , A61K38/50 , A61K38/48 , A61K38/19 , A61K38/18 , A61K38/28 , A61K31/785 , C12N9/02 , C12N9/24 , C12N9/48
CPC分类号： B82Y5/00 , A61K47/56 , A61K47/6949 , Y10S977/70 , Y10S977/702 , Y10S977/705 , Y10S977/754
摘要： The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
摘要翻译： 本申请涉及包含连接到核和生物活性部分的超支化聚合物的组合物。 生物活性部分通过基本上非酶切割的接头L连接到芯上。该组合物可用于将生物活性部分递送至其靶。
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公开(公告)号：US09056126B2
公开(公告)日：2015-06-16
申请号：US13111777
申请日：2011-05-19
申请人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
发明人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
IPC分类号： A61K39/395 , A61F13/00 , A61K39/00 , A61K39/38 , A61K9/14 , A61K31/785 , A61K31/795 , A61K47/48
CPC分类号： A61K47/60 , A61K31/7088 , A61K31/785 , A61K31/795 , A61K38/28 , A61K47/645 , A61K47/65 , A61K47/6903 , B82Y5/00
摘要： A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
摘要翻译： 包含水凝胶，生物活性部分和可逆前药接头的聚合物前药组合物。 前药接头将水凝胶和生物活性部分共价连接在一个位置，并且水凝胶在其表面上具有多个具有开口的孔。 至少在孔的至少一个开口和生物活性部分的位置之间，孔的直径大于生物活性部分的直径。
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公开(公告)号：US08377917B2
公开(公告)日：2013-02-19
申请号：US10594097
申请日：2005-03-22
申请人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
发明人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
IPC分类号： A61K31/33
CPC分类号： A61K47/48246 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/643 , A61K47/6903 , C07C69/96 , C07D207/46 , C07D401/12 , C07K14/00 , C07K14/61 , C07K14/62
摘要： A cascade carrier linked prodrug is described which comprises a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.
摘要翻译： 描述了级联载体连接的前药，其包含生物活性部分和具有至少一个亲核体并且与载体不同的掩蔽基团。
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公开(公告)号：US20110223230A1
公开(公告)日：2011-09-15
申请号：US13111777
申请日：2011-05-19
申请人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
发明人： Ulrich Hersel , Harald Rau , Robert Schnepf , Dirk Vetter , Thomas Wegge
IPC分类号： A61K9/14 , A61K9/00 , A61K38/46 , A61K38/43 , A61K38/38 , A61K39/395 , A61K38/48 , A61K38/47 , A61K38/36 , A61K38/37 , A61K38/57 , A61K38/16 , A61K39/00 , A61K38/18 , A61K38/24 , A61K38/26 , A61K38/09 , A61K38/00 , A61K39/02 , A61K38/22 , A61K38/44 , A61K38/21 , A61K38/49 , A61K31/197 , A61K31/7088 , A61K38/19 , A61K38/20 , A61P37/04 , A61P37/00 , A61P7/00 , A61K38/28
CPC分类号： A61K47/60 , A61K31/7088 , A61K31/785 , A61K31/795 , A61K38/28 , A61K47/645 , A61K47/65 , A61K47/6903 , B82Y5/00
摘要： A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
摘要翻译： 包含水凝胶，生物活性部分和可逆前药接头的聚合物前药组合物。 前药接头将水凝胶和生物活性部分共价连接在一个位置，并且水凝胶在其表面上具有多个具有开口的孔。 至少在孔的至少一个开口和生物活性部分的位置之间，孔的直径大于生物活性部分的直径。
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公开(公告)号：US20110172390A1
公开(公告)日：2011-07-14
申请号：US12967285
申请日：2010-12-14
申请人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
发明人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
IPC分类号： A61K38/28 , C07K14/805
CPC分类号： B82Y5/00 , A61K47/56 , A61K47/6949 , Y10S977/70 , Y10S977/702 , Y10S977/705 , Y10S977/754
摘要： The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
摘要翻译： 本申请涉及包含连接到核和生物活性部分的超支化聚合物的组合物。 生物活性部分通过基本上非酶切割的接头L连接到芯上。该组合物可用于将生物活性部分递送至其靶。
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公开(公告)号：US07879588B2
公开(公告)日：2011-02-01
申请号：US10574213
申请日：2004-10-01
申请人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
发明人： Dirk Vetter , Ulrich Hersel , Harald Rau , Robert Schnepf , Thomas Wegge
CPC分类号： B82Y5/00 , A61K47/56 , A61K47/6949 , Y10S977/70 , Y10S977/702 , Y10S977/705 , Y10S977/754
摘要： The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target.
摘要翻译： 本申请涉及包含连接到核和生物活性部分的超支化聚合物的组合物。 生物活性部分通过基本上非酶切割的接头L连接到芯上。该组合物可用于将生物活性部分递送至其靶。
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