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1.发明申请4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP 有权含有苏氨酸组的4-芳基-N-苯基-1,3,5-三嗪-2-氨基公开(公告)号：US20140315906A1
公开(公告)日：2014-10-23
申请号：US14122063
申请日：2012-05-21
申请人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Dirk Kosemund , Philip Lienau , Gerd Rühter , Carsten Schultz-Fademrecht
发明人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Dirk Kosemund , Philip Lienau , Gerd Rühter , Carsten Schultz-Fademrecht
IPC分类号： C07D251/22 , A61K31/53 , C07D417/12 , C07D405/12 , C07D401/12 , C07D405/04 , C07C381/10
CPC分类号： A61K31/53 , C07B59/002 , C07B2200/05 , C07C381/10 , C07D251/16 , C07D251/22 , C07D251/42 , C07D251/44 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）或（Ia）的亚磺酰亚胺基的4-芳基-N-苯基-1,3,5-三嗪-2-胺及其制备方法， 它们用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病的用途。 本发明还涉及可用于制备所述通式（I）或（Ia）化合物的中间体化合物。
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公开(公告)号：US09669034B2
公开(公告)日：2017-06-06
申请号：US14122063
申请日：2012-05-21
申请人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Dirk Kosemund , Philip Lienau , Gerd Rühter , Carsten Schultz-Fademrecht
发明人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Dirk Kosemund , Philip Lienau , Gerd Rühter , Carsten Schultz-Fademrecht
IPC分类号： C07D251/42 , C07D251/44 , C07D405/04 , A61K31/53 , A61P35/00 , C07D251/16 , C07D251/22 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07C381/10
CPC分类号： A61K31/53 , C07B59/002 , C07B2200/05 , C07C381/10 , C07D251/16 , C07D251/22 , C07D251/42 , C07D251/44 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
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公开(公告)号：US08916557B2
公开(公告)日：2014-12-23
申请号：US14112484
申请日：2012-04-18
申请人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Gerd Rühter , Carsten Schultz-Fademrecht , Dirk Kosemund , Philip Lienau
发明人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bömer , Gerd Rühter , Carsten Schultz-Fademrecht , Dirk Kosemund , Philip Lienau
IPC分类号： C07D251/42 , C07D401/04 , C07D405/04 , C07D401/12 , C07D405/12
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
摘要： The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的取代的4-芳基-N-苯基-1,3,5-三嗪-2-胺及其制备方法及其用于治疗和/ 或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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公开(公告)号：US20140045852A1
公开(公告)日：2014-02-13
申请号：US14112484
申请日：2012-04-18
申请人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bomer , Gerd Rühter , Carsten Schultz-Fademrecht , Dirk Kosemund , Philip Lienau
发明人： Ulrich Lücking , Rolf Bohlmann , Arne Scholz , Gerhard Siemeister , Mark Jean Gnoth , Ulf Bomer , Gerd Rühter , Carsten Schultz-Fademrecht , Dirk Kosemund , Philip Lienau
IPC分类号： C07D251/42 , C07D401/04 , C07D405/04
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
摘要： The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的取代的4-芳基-N-苯基-1,3,5-三嗪-2-胺及其制备方法及其用于治疗和/ 或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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公开(公告)号：US09108926B2
公开(公告)日：2015-08-18
申请号：US14343983
申请日：2012-09-13
申请人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
发明人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
IPC分类号： C07D239/42 , C07D401/12 , C07D407/04 , A61K31/505 , A61K31/506 , C07D405/04
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/04 , C07D407/04
摘要： The present invention relates to disubstituted 5-fluoro-pyrimidines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的二取代的5-氟 - 嘧啶及其制备方法，其用于治疗和/或预防病症，特别是高增殖性疾病和/ 或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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6.发明申请DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权分解含有硫代酰胺基团的5-氟氟嘧啶衍生物公开(公告)号：US20150005329A1
公开(公告)日：2015-01-01
申请号：US14345353
申请日：2012-09-13
申请人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
发明人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
IPC分类号： C07D405/04 , C07C381/10 , A61K31/506 , C07D239/42 , A61K31/505
CPC分类号： C07D405/04 , A61K31/505 , A61K31/506 , C07C381/10 , C07D239/42
摘要： The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的亚磺酰亚胺基团的二取代的5-氟嘧啶衍生物及其制备方法，其用于治疗和/或预防病症， 增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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7.发明授权Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group 有权含有亚砜亚胺基的二取代的5-氟嘧啶衍生物公开(公告)号：US09133171B2
公开(公告)日：2015-09-15
申请号：US14345353
申请日：2012-09-13
申请人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
发明人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
IPC分类号： A61K31/506 , C07D405/04 , C07D239/42 , C07C381/10 , A61K31/505
CPC分类号： C07D405/04 , A61K31/505 , A61K31/506 , C07C381/10 , C07D239/42
摘要： The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的亚磺酰亚胺基团的二取代的5-氟嘧啶衍生物及其制备方法，其用于治疗和/或预防病症， 增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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公开(公告)号：US20140228387A1
公开(公告)日：2014-08-14
申请号：US14343983
申请日：2012-09-13
申请人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
发明人： Ulrich Lücking , Dirk Kosemund , Arne Scholz , Philip Lienau , Gerhard Siemeister , Ulf Bömer , Rolf Bohlmann
IPC分类号： C07D239/42 , C07D401/12 , A61K31/506 , A61K31/505 , C07D405/04
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/04 , C07D407/04
摘要： The present invention relates to disubstituted 5-fluoro-pyrimidines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及本文所述和定义的通式（I）的二取代的5-氟 - 嘧啶及其制备方法，其用于治疗和/或预防病症，特别是高增殖性疾病和/ 或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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9.发明授权Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine 有权砜取代的苯胺基嘧啶衍生物作为CDK抑制剂，其制备及用作药物公开(公告)号：US08802686B2
公开(公告)日：2014-08-12
申请号：US13125144
申请日：2009-10-08
IPC分类号： A61K31/505 , C07D239/24
CPC分类号： C07D239/47
摘要： The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I), to its preparation processes, and to its use as medicament for treating various diseases.
摘要翻译： 本发明涉及式（I）的砜取代的苯胺基嘧啶衍生物及其制备方法，以及其用作治疗各种疾病的药物。
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10.发明授权Sulfoximine-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as medicine 有权磺酰亚胺取代的苯胺基嘧啶衍生物作为CDK抑制剂，其制备及用作药物公开(公告)号：US08735412B2
公开(公告)日：2014-05-27
申请号：US13125066
申请日：2009-10-09
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/47
摘要： The invention relates to sulfoximine-substituted anilino-pyrimidine derivatives of formula (I). methods of production thereof, and use thereof as medication for the treatment of various diseases.
摘要翻译： 本发明涉及式（I）的磺酰亚胺取代的苯胺基 - 嘧啶衍生物。 其生产方法及其用作治疗各种疾病的药物。
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