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    ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
    6.
    发明申请
    ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME 有权
    因子XA抑制剂的抗体及其使用方法

    公开(公告)号：US20130129693A1

    公开(公告)日：2013-05-23

    申请号：US13591098

    申请日：2012-08-21

    申请人： Uma Sinha ,  Genmin Lu ,  Pamela B. Conley

    发明人： Uma Sinha ,  Genmin Lu ,  Pamela B. Conley

    IPC分类号： C07K14/745

    CPC分类号： C12N9/6432 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/4833 ,  A61K38/4846 ,  A61K38/4853 ,  A61K39/00 ,  A61K47/60 ,  C12Y304/21006

    摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

    摘要翻译： 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子X和因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开的是使用因子Xa抑制剂正在进行抗凝治疗的患者中的抗凝，停止或预防出血的方法。

    Antidotes for factor Xa inhibitors and methods of using the same
    8.
    发明授权
    Antidotes for factor Xa inhibitors and methods of using the same 有权
    因子Xa抑制剂的解毒剂及其使用方法

    公开(公告)号：US09109046B2

    公开(公告)日：2015-08-18

    申请号：US13591098

    申请日：2012-08-21

    申请人： Uma Sinha ,  Genmin Lu ,  Pamela B. Conley

    发明人： Uma Sinha ,  Genmin Lu ,  Pamela B. Conley

    IPC分类号： A61K39/00 ,  C07K14/745 ,  A61K38/48 ,  A61K47/48 ,  C12N9/64

    CPC分类号： C12N9/6432 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/4833 ,  A61K38/4846 ,  A61K38/4853 ,  A61K39/00 ,  A61K47/60 ,  C12Y304/21006

    摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

    摘要翻译： 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子X和因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开的是使用因子Xa抑制剂正在进行抗凝治疗的患者中的抗凝，停止或预防出血的方法。

    Antidotes for factor Xa inhibitors and methods of using the same
    9.
    发明授权
    Antidotes for factor Xa inhibitors and methods of using the same 有权
    因子Xa抑制剂的解毒剂及其使用方法

    公开(公告)号：US08268783B2

    公开(公告)日：2012-09-18

    申请号：US12749217

    申请日：2010-03-29

    申请人： Uma Sinha ,  Genmin Lu ,  Pamela B. Conley

    发明人： Uma Sinha ,  Genmin Lu ,  Pamela B. Conley

    IPC分类号： A61K38/57

    CPC分类号： C12N9/6432 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/4833 ,  A61K38/4846 ,  A61K38/4853 ,  A61K39/00 ,  A61K47/60 ,  C12Y304/21006

    摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

    摘要翻译： 本发明涉及靶向因子Xa的抗凝剂的解毒剂。 解毒剂是与因子Xa抑制剂结合的因子X和因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。 本文所述的衍生物缺乏或具有降低的内在凝结剂活性。 本文公开的是使用因子Xa抑制剂正在进行抗凝治疗的患者中的抗凝，停止或预防出血的方法。