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1.发明申请Glutathione Derivatives and Their Uses for the Treatment of Viral Diseases 审中-公开谷胱甘肽衍生物及其用于治疗病毒性疾病的用途公开(公告)号：US20120165248A1
公开(公告)日：2012-06-28
申请号：US13272036
申请日：2011-10-12
申请人： Umberto Benatti , Giorgio Brandi , Enrico Garaci , Mauro Magnani , Enrico Millo , Anna Taresa Palamara , Luigia Rossi
发明人： Umberto Benatti , Giorgio Brandi , Enrico Garaci , Mauro Magnani , Enrico Millo , Anna Taresa Palamara , Luigia Rossi
CPC分类号： A61K38/063 , C07K5/0215
摘要： Glutathione derivatives (GSH) of formula I are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.
摘要翻译： 提供式I的谷胱甘肽衍生物（GSH），其中R是硫醇保护基。 该衍生物可用于治疗副粘病毒，正粘病毒，单纯疱疹病毒和获得性免疫缺陷综合征病毒感染。
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2.发明申请Glutathione Derivatives and Their Uses for the Treatment of Viral Diseases 审中-公开谷胱甘肽衍生物及其用于治疗病毒性疾病的用途公开(公告)号：US20070270349A1
公开(公告)日：2007-11-22
申请号：US10584874
申请日：2004-12-29
申请人： Umberto Benatti , Giorgio Brandi , Enrico Garaci , Mauro Magnani , Enrico Millo , Anna Palamara , Luigia Rossi
发明人： Umberto Benatti , Giorgio Brandi , Enrico Garaci , Mauro Magnani , Enrico Millo , Anna Palamara , Luigia Rossi
CPC分类号： A61K38/063 , C07K5/0215
摘要： Glutathione derivatives (GSH) of formula (I) are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.
摘要翻译： 提供式（I）的谷胱甘肽衍生物（GSH），其中R是硫醇保护基。 该衍生物可用于治疗副粘病毒，正粘病毒，单纯疱疹病毒和获得性免疫缺陷综合征病毒感染。
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3.发明授权Use of thymosin alpha 1, alone or in combination with PTX3 or ganciclovir, for the treatment of cytomegalovirus infection 有权单独或与PTX3或更昔洛韦组合使用胸腺素α1用于治疗巨细胞病毒感染公开(公告)号：US08337828B2
公开(公告)日：2012-12-25
申请号：US12298643
申请日：2007-04-12
申请人： Luigina Romani , Francesco Bistoni , Enrico Garaci
发明人： Luigina Romani , Francesco Bistoni , Enrico Garaci
CPC分类号： A61K38/1709 , A61K31/522 , A61K38/2292 , A61K2300/00
摘要： It is described the use of thymosin alpha 1 in combination with long pentraxin PTX3 or Ganciclovir, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
摘要翻译： 描述了使用胸腺素α1与长五倍体PTX3或更昔洛韦组合，用于制备用于预防或治疗病毒性疾病和/或抑制病毒活化的药物。
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公开(公告)号：US08022036B2
公开(公告)日：2011-09-20
申请号：US12272573
申请日：2008-11-17
申请人： Luigina Romani , Francesco Bistoni , Enrico Garaci
发明人： Luigina Romani , Francesco Bistoni , Enrico Garaci
CPC分类号： A61K31/454 , A61K31/436 , A61K31/56 , A61K31/675 , A61K38/13 , A61K38/2292 , A61K2300/00
摘要： It is described the use of thymosin alpha 1 for preparing a medicament useful for the prevention or treatment of graft-versus-host disease or graft rejection reactions in organ transplantation, in a mammal subject, in which the cells, tissues or organs for transplant is selected from the group comprising: stem cells, hematopoietic stem cells, bone marrow, heart, liver, kidney, lung, pancreas, small intestine, cornea or skin.
摘要翻译： 描述了胸腺素α1在哺乳动物受试者中制备用于预防或治疗器官移植中的移植物抗宿主病或移植排斥反应的药物的用途，其中用于移植的细胞，组织或器官是 选自干细胞，造血干细胞，骨髓，心脏，肝，肾，肺，胰腺，小肠，角膜或皮肤。
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5.发明申请USE OF THYMOSIN ALPHA 1, ALONE OR IN COMBINATION WITH PTX3 OR GANCICLOVIR, FOR THE TREATMENT OF CYTOMEGALOVIRUS INFECTION 有权使用甲硫氨酸ALPHA 1，单独或与PTX3或GANCICLOVIR组合，用于治疗细胞病毒感染公开(公告)号：US20090275508A1
公开(公告)日：2009-11-05
申请号：US12298643
申请日：2007-04-12
申请人： Luigina Romani , Francesco Bistoni , Enrico Garaci
发明人： Luigina Romani , Francesco Bistoni , Enrico Garaci
CPC分类号： A61K38/1709 , A61K31/522 , A61K38/2292 , A61K2300/00
摘要： It is described the use of thymosin alpha 1 in combination with long pentraxin PTX3 or Ganciclovir, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for inhibiting virus activation.
摘要翻译： 描述了使用胸腺素α1与长五倍体PTX3或更昔洛韦组合，用于制备用于预防或治疗病毒性疾病和/或抑制病毒活化的药物。
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公开(公告)号：US20090203892A1
公开(公告)日：2009-08-13
申请号：US11794554
申请日：2005-12-30
申请人： Enrico Garaci , Paola Sinibaldi , Corrado Spadafora , Carmine Pittoggi , Ilaria Sciamanna , Cristina Mearelli
发明人： Enrico Garaci , Paola Sinibaldi , Corrado Spadafora , Carmine Pittoggi , Ilaria Sciamanna , Cristina Mearelli
IPC分类号： A61K31/7105 , A61K31/711 , C07H21/02
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12Y207/07049
摘要： RNA interference is useful in the treatment of cancerous lesions, wherein the RNA recognises a portion of at least one LINE-I repeat element.
摘要翻译： RNA干扰可用于治疗癌性病变，其中RNA识别至少一种LINE-1重复元件的一部分。
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公开(公告)号：US20070129292A1
公开(公告)日：2007-06-07
申请号：US10551341
申请日：2004-03-29
IPC分类号： A61K38/55 , A61K31/7048
CPC分类号： A61K31/7048 , A61K38/2292 , A61K2300/00
摘要： A method for treating a human infected with Aspergillus by using thymosin alpha 1 as an immuno-stimulator in activating dendritic cells. The method is particularly useful in preventing an infection by Aspergillus in an immuno-compromised host being treated with a bone marrow transplantation.
摘要翻译： 一种通过使用胸腺素α1作为免疫刺激剂激活树突状细胞来治疗被曲霉菌感染的人的方法。 该方法特别可用于防止由用骨髓移植治疗的免疫受损宿主中的曲霉菌感染。
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公开(公告)号：US08785493B2
公开(公告)日：2014-07-22
申请号：US13125325
申请日：2009-10-29
CPC分类号： A61K33/36 , A61K31/167 , A61K31/198 , A61K31/28 , A61K31/295 , A61K31/4406 , A61K31/513 , A61K31/555 , A61K31/7024 , A61K33/04 , A61K33/26 , A61K45/06 , A61K2300/00
摘要： Activation of HIV-1 replication causes oxidative stress, which in turn potentiates HIV-1 replication. The common basis for the compounds of the present invention is: A) the capacity of reactivating HIV-1 from latency, and B) the ability to counteract the cellular machinery which activates in order to limit the effects of oxidative stress. In this way, oxidative stress can be potentiated and a “chain reaction” is sparked. This “chain reaction” induces a more efficient reactivation of HIV-1 from latency and, in some cases, induces selective killing of the infected cells. Actions A) and B) can either be carried out by one drug exerting both effects, or obtained by the combined use of distinct drugs. There are two main cellular machineries counteracting oxidative stress, i.e. the thioredoxin (Trx) thioredoxin reductase (TrxR) system and glutathione. Herein, we present drug strategies capable of exerting action B) by blocking either of the two machineries.
摘要翻译： HIV-1复制的激活导致氧化应激，这反过来加强了HIV-1的复制。 本发明化合物的共同基础是：A）从潜伏期重新激活HIV-1的能力，以及B）抵抗激活以抑制氧化应激作用的细胞机制的能力。 以这种方式，可以增强氧化应激，引发“连锁反应”。 这种“连锁反应”诱导HIV-1从潜伏期更有效的再活化，并且在某些情况下诱导对感染细胞的选择性杀伤。 动作A）和B）可以由一种既能发挥作用的药物也可以通过组合使用不同药物而获得。 有两个主要的细胞机制抵消氧化应激，即硫氧还蛋白（Trx）硫氧还蛋白还原酶（TrxR）系统和谷胱甘肽。 在这里，我们提出能够通过阻止两个机器中的任何一个来施加动作B）的药物策略。
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公开(公告)号：US08207294B2
公开(公告)日：2012-06-26
申请号：US10551341
申请日：2004-03-29
CPC分类号： A61K31/7048 , A61K38/2292 , A61K2300/00
摘要： A method for treating a human infected with Aspergillus by using thymosin alpha 1 as an immuno-stimulator in activating dendritic cells. The method is particularly useful in preventing an infection by Aspergillus in an immuno-compromised host being treated with a bone marrow transplantation.
摘要翻译： 一种通过使用胸腺素α1作为免疫刺激剂激活树突状细胞来治疗被曲霉菌感染的人的方法。 该方法特别可用于防止由用骨髓移植治疗的免疫受损宿主中的曲霉菌感染。
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10.发明申请Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds 审中-公开通过施用环戊烯酮化合物治疗炎性和病毒性疾病的方法公开(公告)号：US20050020687A1
公开(公告)日：2005-01-27
申请号：US10742523
申请日：2003-12-19
申请人： Maria Santoro , Antonio Rossi , Giuliano Elia , Enrico Garaci , Carla Amici
发明人： Maria Santoro , Antonio Rossi , Giuliano Elia , Enrico Garaci , Carla Amici
IPC分类号： A61K31/00 , A61K31/122 , A61K31/557
CPC分类号： A61K31/122 , A61K31/00 , Y02A50/387 , Y02A50/389 , Y02A50/463
摘要： The present invention relates to methods and compositions for the treatment and/or prevention of diseases and disorders in humans, including cancer, inflammatory diseases or disorders, and infectious diseases. In particular, the present invention relates to methods and compositions comprising the administration of a cyclopentenone prostaglandin or a derivative thereof, which induces cytoprotective responses and inhibits NF-κB activation. The present invention further relates to pharmaceutical compositions containing cyclopentenone prostaglandins for the treatment and/or prevention of viral infection, inflammation, and/or cancer in humans.
摘要翻译： 本发明涉及用于治疗和/或预防人类疾病和病症的方法和组合物，包括癌症，炎性疾病或病症和感染性疾病。 特别地，本发明涉及包含施用环戊烯酮前列腺素或其衍生物的方法和组合物，其诱导细胞保护反应并抑制NF-κB活化。 本发明还涉及含有环戊烯酮前列腺素用于治疗和/或预防人类病毒感染，炎症和/或癌症的药物组合物。
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