公开(公告)号：US20240282424A1

公开(公告)日：2024-08-22

申请号：US18654586

申请日：2024-05-03

申请人： Universität Basel

发明人： Gabor Szinnai ,  Gilbert Koch ,  Marc Pfister ,  Johannes Schropp ,  Britta Steffens ,  Freya Bachmann

IPC分类号： G16H20/10 ,  A61B5/024 ,  G06N3/02 ,  G16H50/50

CPC分类号： G16H20/10 ,  A61B5/02438 ,  G06N3/02 ,  G16H50/50

摘要： The present description relates to a method for automatically determining an optimal individual dosing regimen of at least one drug. The method includes providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient. The method includes utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model. The method includes automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen. The method includes adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen.