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公开(公告)号：US20240282424A1
公开(公告)日：2024-08-22
申请号：US18654586
申请日：2024-05-03
Applicant: Universität Basel
Inventor： Gabor Szinnai , Gilbert Koch , Marc Pfister , Johannes Schropp , Britta Steffens , Freya Bachmann
CPC classification number: G16H20/10 , A61B5/02438 , G06N3/02 , G16H50/50
Abstract: The present description relates to a method for automatically determining an optimal individual dosing regimen of at least one drug. The method includes providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient. The method includes utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model. The method includes automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen. The method includes adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen.
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公开(公告)号：US11662354B2
公开(公告)日：2023-05-30
申请号：US17695714
申请日：2022-03-15
Applicant: UNIVERSITÄT BASEL
Inventor： Gilbert Koch , Sven Wellmann , Marc Pfister , Severin Kasser , Melanie Wilbaux
CPC classification number: G01N33/728 , G06F17/18 , G16H10/00 , G16H50/20 , Y10T436/146666
Abstract: The invention relates to a method and a computer program for estimating a bilirubin level of a neonate, composed of the steps of:
Acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate,
Acquiring a plurality of covariates from the neonate, each composed of an information about a neonatal property,
Providing a pre-defined bilirubin model function, wherein the bilirubin model function is configured to describe a time course of a bilirubin level of a neonate,
Determining a plurality of model parameters of the bilirubin model function, wherein each model parameter is estimated from at least one covariate of the plurality of covariates and an associated population model parameter,
Determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.-
公开(公告)号：US11656234B2
公开(公告)日：2023-05-23
申请号：US16651992
申请日：2018-09-27
Applicant: UNIVERSITÄT BASEL
Inventor： Gilbert Koch , Sven Wellmann , Marc Pfister , Severin Kasser , Melanie Wilbaux
CPC classification number: G01N33/728 , G06F17/18 , G16H10/00 , G16H50/20 , Y10T436/146666
Abstract: The invention relates to a method and a computer program for estimating a bilirubin level of a neonate, composed of the steps of:
Acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate,
Acquiring a plurality of covariates from the neonate, each composed of an information about a neonatal property,
Providing a pre-defined bilirubin model function, wherein the bilirubin model function is configured to describe a time course of a bilirubin level of a neonate,
Determining a plurality of model parameters of the bilirubin model function, wherein each model parameter is estimated from at least one covariate of the plurality of covariates and an associated population model parameter,
Determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.
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