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1.发明授权Technology and method to study microbial growth and adhesion to host-related surfaces and the host-microbiota interaction 有权研究微生物生长和与宿主相关表面和宿主 - 微生物群落相互作用的粘附的技术和方法公开(公告)号：US08703479B2
公开(公告)日：2014-04-22
申请号：US13861590
申请日：2013-04-12
Applicant: Universiteit Gent
Inventor： Massimo Marzorati , Sam Possemiers , Pieter Van Den Abbeele , Tom Van De Wiele , Barbara Vanhoecke , Willy Verstraete
IPC: C12M1/12
CPC classification number: C12N5/0679 , C12M23/34 , C12M29/04 , C12M41/34 , C12N11/02
Abstract: A method is provided for co-culturing viable cells and microorganisms for at least 48 hours in which an adhesion module is provided including a basal compartment and a luminal compartment separated by a semi-permeable membrane, and a continuous or semi-continuous flow of fresh medium is applied to the basal compartment.
Abstract translation: 提供一种用于共培养活细胞和微生物至少48小时的方法，其中提供粘附模块，其包括基室和由半透膜隔开的腔室，以及连续或半连续的新鲜流 培养基施加到基底室。
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公开(公告)号：US09290427B2
公开(公告)日：2016-03-22
申请号：US14375270
申请日：2013-01-30
Applicant: Universiteit Gent
Inventor： Marc Bracke , Christian Stevens , Tine De Ryck , Bart Roman , Barbara Vanhoecke
IPC: A61K31/341 , C07D307/46 , C07C49/223 , A61K31/12 , A61K31/34 , G06F19/00
CPC classification number: C07C49/223 , A61K31/12 , A61K31/34 , C07D307/46 , G06F19/704
Abstract: The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.
Abstract translation: 本发明涉及抗侵入化合物领域和预测所述化合物的抗侵袭活性的方法及其在预防和/或治疗与不期望的细胞侵袭相关的疾病中的用途; 特别是，本发明涉及抗侵入查耳酮类化合物的领域。
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公开(公告)号：US20150011620A1
公开(公告)日：2015-01-08
申请号：US14375270
申请日：2013-01-30
Applicant: Universiteit Gent
Inventor： Marc Bracke , Christian Stevens , Tine De Ryck , Bart Roman , Barbara Vanhoecke
IPC: C07C49/223 , C07D307/46 , G06F19/00
CPC classification number: C07C49/223 , A61K31/12 , A61K31/34 , C07D307/46 , G06F19/704
Abstract: The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.
Abstract translation: 本发明涉及抗侵入化合物领域和预测所述化合物的抗侵袭活性的方法及其在预防和/或治疗与不期望的细胞侵袭相关的疾病中的用途; 特别地，本发明涉及抗侵入性查耳酮样化合物领域。
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4.发明申请TECHNOLOGY AND METHOD TO STUDY MICROBIAL GROWTH AND ADHESION TO HOST-RELATED SURFACES AND THE HOST-MICROBIOTA INTERACTION 有权研究微生物生长和粘附于与生物相关的表面和主动微生物相互作用的技术和方法公开(公告)号：US20130203161A1
公开(公告)日：2013-08-08
申请号：US13861590
申请日：2013-04-12
Applicant: Universiteit Gent
Inventor： Massimo Marzorati , Sam Possemiers , Pieter Van Den Abbeele , Tom Van De Wiele , Barbara Vanhoecke , Willy Verstraete
IPC: C12N5/071
CPC classification number: C12N5/0679 , C12M23/34 , C12M29/04 , C12M41/34 , C12N11/02
Abstract: A method is provided for co-culturing viable cells and microorganisms for at least 48 hours in which an adhesion module is provided including a basal compartment and a luminal compartment separated by a semi-permeable membrane, and a continuous or semi-continuous flow of fresh medium is applied to the basal compartment.
Abstract translation: 提供一种用于共培养活细胞和微生物至少48小时的方法，其中提供粘附模块，其包括基室和由半透膜隔开的腔室，以及连续或半连续的新鲜流 培养基施加到基底室。
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