公开(公告)号：US09586973B2

公开(公告)日：2017-03-07

申请号：US14858350

申请日：2015-09-18

Applicant: Universiteit Gent

Inventor： Marc Bracke ,  Matthias D'hooghe ,  Rob De Vreese

IPC: C07D495/04 ,  A61K31/407 ,  A61K45/06

CPC classification number: C07D495/04 ,  A61K31/407 ,  A61K45/06 ,  Y02A50/411

Abstract: Histone deacetylases 6 (HDAC6) inhibitors and compositions containing the same. Methods of treating diseases and conditions wherein inhibition of HDAC6 provides a benefit, like a cell proliferative disease, an autoimmune or inflammatory disorder, a neurodegenerative disease, a viral disease, malaria, or a combination thereof.

Abstract translation: 组蛋白脱乙酰酶6（HDAC6）抑制剂和含有它们的组合物。 治疗疾病和病症的方法，其中HDAC6的抑制提供益处，如细胞增殖性疾病，自身免疫性或炎性疾病，神经变性疾病，病毒性疾病，疟疾或其组合。

公开(公告)号：US09290427B2

公开(公告)日：2016-03-22

申请号：US14375270

申请日：2013-01-30

Applicant: Universiteit Gent

Inventor： Marc Bracke ,  Christian Stevens ,  Tine De Ryck ,  Bart Roman ,  Barbara Vanhoecke

IPC: A61K31/341 ,  C07D307/46 ,  C07C49/223 ,  A61K31/12 ,  A61K31/34 ,  G06F19/00

CPC classification number: C07C49/223 ,  A61K31/12 ,  A61K31/34 ,  C07D307/46 ,  G06F19/704

Abstract: The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.

Abstract translation: 本发明涉及抗侵入化合物领域和预测所述化合物的抗侵袭活性的方法及其在预防和/或治疗与不期望的细胞侵袭相关的疾病中的用途; 特别是，本发明涉及抗侵入查耳酮类化合物的领域。

公开(公告)号：US20150011620A1

公开(公告)日：2015-01-08

申请号：US14375270

申请日：2013-01-30

Applicant: Universiteit Gent

Inventor： Marc Bracke ,  Christian Stevens ,  Tine De Ryck ,  Bart Roman ,  Barbara Vanhoecke

IPC: C07C49/223 ,  C07D307/46 ,  G06F19/00

CPC classification number: C07C49/223 ,  A61K31/12 ,  A61K31/34 ,  C07D307/46 ,  G06F19/704

Abstract: The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.

Abstract translation: 本发明涉及抗侵入化合物领域和预测所述化合物的抗侵袭活性的方法及其在预防和/或治疗与不期望的细胞侵袭相关的疾病中的用途; 特别地，本发明涉及抗侵入性查耳酮样化合物领域。