公开(公告)号：US20240075184A1

公开(公告)日：2024-03-07

申请号：US18272765

申请日：2022-01-10

申请人： University of Georgia Research Foundation, Inc.

发明人： Ramaraja P. Ramasamy ,  Hamid Asadi

IPC分类号： A61L27/34 ,  A61F2/28 ,  A61L27/04 ,  A61L27/50 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L27/34 ,  A61F2/28 ,  A61L27/047 ,  A61L27/50 ,  A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61F2002/30062

摘要： Provided are biodegradable orthopedic implants, corrosion-resistant coating for orthopedic implants, and methods of making. The biodegradable orthopedic implant can include a Mg alloy having a coating including a first layer, a second layer, and a third layer. The first layer can be an oxide layer coated on an external surface of a magnesium alloy implant. The second layer can include lawsone embedded in PCL, and the third layer can include PCL. To manufacture the coated orthopedic implant, the implant can be immersed in an alkaline solution to form an oxide-coated implant and implant can then be coated with a PCL lawsone solution. An additional polymer protective layer can be added.

公开(公告)号：US20240269345A1

公开(公告)日：2024-08-15

申请号：US18562997

申请日：2022-05-18

申请人： University of Georgia Research Foundation, Inc.

发明人： Hamid Asadi ,  Ramaraja P. Ramasamy

IPC分类号： A61L27/34 ,  A61L27/04 ,  A61L27/58 ,  C09D5/08 ,  C09D101/02 ,  C09D189/00

CPC分类号： A61L27/34 ,  A61L27/047 ,  A61L27/58 ,  C09D5/08 ,  C09D101/02 ,  C09D189/00 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/02

摘要： Biodegradable orthopedic implants and coatings for the implants are provided. The implant can include a Mg alloy and a coating, where the coating includes silk fibroin. The coating can be anticorrosive and can include a first layer comprising polydopamine and a second layer comprising silk fibroin. The silk fibroin can be combined with cellulose nanocrystals. Methods for making coated orthopedic implants are also provided.