公开(公告)号：US11016082B2

公开(公告)日：2021-05-25

申请号：US15223756

申请日：2016-07-29

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra ,  Victor van Berkel

IPC: G01N33/497 ,  A61B5/08 ,  H01J49/00 ,  H01J49/38 ,  G01N30/72 ,  G01N33/543 ,  G01N33/574 ,  G01N33/64 ,  A61B5/091

Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

公开(公告)号：US20150064796A1

公开(公告)日：2015-03-05

申请号：US14471793

申请日：2014-08-28

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra

IPC: G01N33/574 ,  G01N1/40

CPC classification number: G01N33/57423 ,  G01N1/405 ,  G01N33/543 ,  G01N33/57484 ,  G01N33/64 ,  G01N2033/4975 ,  G01N2033/57453

Abstract: A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for lung cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for lung cancer in the subject specimen.

Abstract translation: 提供了一种在受试者标本中检测或筛选肺癌的非侵入性方法。 该方法包括检测作为来自受试者标本的呼出气中肺癌生物标志物的一种或多种含羰基挥发性有机化合物（VOC）的升高水平。 该方法可以进一步包括从主体样本获得呼出的呼吸; 形成含羰基VOCs与反应性化合物的加成物; 量化含羰基VOC的加合物以建立每种加合物的主题值; 并将每个受试者值与含羰基VOC的加合物的阈值健康标本值进行比较。 一个或多个数量大于阈值健康标本值的受试者值也可用于筛选受检标本中的肺癌。

公开(公告)号：US09638695B2

公开(公告)日：2017-05-02

申请号：US14471793

申请日：2014-08-28

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra

IPC: G01N33/574 ,  G01N1/40 ,  G01N33/543 ,  G01N33/64 ,  G01N33/497

CPC classification number: G01N33/57423 ,  G01N1/405 ,  G01N33/543 ,  G01N33/57484 ,  G01N33/64 ,  G01N2033/4975 ,  G01N2033/57453

Abstract: A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for lung cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for lung cancer in the subject specimen.

公开(公告)号：US20210318290A1

公开(公告)日：2021-10-14

申请号：US17238082

申请日：2021-04-22

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra ,  Victor van Berkel

IPC: G01N33/497 ,  H01J49/00 ,  H01J49/38 ,  G01N30/72 ,  G01N33/543 ,  G01N33/574 ,  G01N33/64 ,  A61B5/08

Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

公开(公告)号：US20170030892A1

公开(公告)日：2017-02-02

申请号：US15223756

申请日：2016-07-29

Applicant: University of Louisville Research Foundation, Inc.

Inventor： Xiaoan Fu ,  Michael Nantz ,  Michael Bousamra ,  Victor van Berkel

IPC: G01N33/497 ,  H01J49/38 ,  G01N30/72 ,  H01J49/00

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/091 ,  A61B2505/03 ,  G01N30/72 ,  G01N33/543 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/64 ,  G01N2033/4975 ,  G01N2800/7028 ,  H01J49/0031 ,  H01J49/38

Abstract: Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.

Abstract translation: 本发明提供一种检测或筛选来自肺外组织的受试者标本中的癌症的非侵入性方法。 该方法包括检测作为来自受检标本的呼出气中癌症的生物标志物的一种或多种含羰基的挥发性有机化合物（VOC）的升高水平。 该方法可以进一步包括从主体样本获得呼出的呼吸; 形成含羰基VOCs与反应性化合物的加成物; 量化含羰基VOC的加合物以建立每种加合物的主题值; 并将每个受试者值与含羰基VOC的加合物的阈值健康标本值进行比较。 一个或多个数量大于阈值健康标本值的受试者值也可用于筛选受检标本中的癌症。